A5075063505- Immunotherapy and Immune Responses
- Gut microbiota and health
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Hepatocellular Carcinoma Treatment and Prognosis
- Clostridium difficile and Clostridium perfringens research
- Probiotics and Fermented Foods
- Hepatitis B Virus Studies
- Immune cells in cancer
- Liver Disease and Transplantation
- Gastrointestinal motility and disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA Interference and Gene Delivery
- Cancer Mechanisms and Therapy
- Inflammatory Bowel Disease
- Inflammatory Myopathies and Dermatomyositis
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer Cells and Metastasis
- Angiogenesis and VEGF in Cancer
- Hepatitis C virus research
- Systemic Sclerosis and Related Diseases
- vaccines and immunoinformatics approaches
Kanazawa University Hospital
2014-2025
Kanazawa University
2016-2025
National Cancer Institute
2012-2013
Center for Cancer Research
2013
École Polytechnique Fédérale de Lausanne
2012
National Institutes of Health
2012
University of Cambridge
2012
Oregon Health & Science University
2012
Vanderbilt University
2012
Fondazione IRCCS Istituto Nazionale dei Tumori
2012
The gut microbiota influences both local and systemic inflammation. Inflammation contributes to development, progression, treatment of cancer, but it remains unclear whether commensal bacteria affect inflammation in the sterile tumor microenvironment. Here, we show that disruption impairs response subcutaneous tumors CpG-oligonucleotide immunotherapy platinum chemotherapy. In antibiotics-treated or germ-free mice, tumor-infiltrating myeloid-derived cells responded poorly therapy, resulting...
The tumor microenvironment (TME) consists of cells, soluble factors, signaling molecules, extracellular matrix, and mechanical cues that can promote neoplastic transformation, support growth invasion, protect the from host immunity, foster therapeutic resistance, provide niches for dormant metastases to thrive. An American Association Cancer Research (AACR) special conference held on November 3-6, 2011, addressed five emerging concepts in our understanding TME: its dynamic evolution, how it...
Background/Objectives: Atezolizumab and bevacizumab combination therapy has been established as a standard of care for first-line treatment; however, its efficacy safety have not fully evaluated patients previously treated with systemic therapy. Methods: In this phase II trial, advanced hepatocellular carcinoma lenvatinib were enrolled to receive dose 1,200 mg atezolizumab 15 mg/kg every 3 weeks. The primary endpoint was progression-free survival. secondary endpoints included overall...
The capacity of IL-10 and Tregs in the inflammatory tumor microenvironment to impair anticancer Th1 immunity makes them attractive targets for cancer immunotherapy. also suppress Th17 activity, which is associated with poor prognosis several cancers. However, previous studies have overlooked their potential contribution regulation pathogenic cancer-associated inflammation. In this study, we investigated origin function IL-10–producing cells using transplantable models mice. majority...
Recent metagenomic analyses have revealed dysbiosis of the gut microbiota ulcerative colitis (UC) patients. However, impacts this are not fully understood, particularly at strain level.We perform whole-genome shotgun sequencing fecal DNA extracts from 13 healthy donors and 16 UC 8 Crohn's disease (CD) The CD patients is taxonomically functionally divergent that donors, with E. faecium being most differentially abundant species between two microbial communities. Transplantation feces or into...
OBJECTIVE Nonalcoholic fatty liver disease (NAFLD) is a phenotype of type 2 diabetes and obesity. Currently, the efficacy sodium–glucose cotransporter (SGLT2) inhibitors sulfonylureas in pathology hepatic gene expression profiles for with NAFLD are unknown. RESEARCH DESIGN AND METHODS We conducted 48 week, randomized, open-label, parallel-group trial involving participants biopsy-confirmed NAFLD. A total 40 were randomly assigned to receive once daily 20 mg tofogliflozin or 0.5 glimepiride....
Colonic luminal aromatic amines have been historically considered to be derived from dietary source, especially fermented foods; however, recent studies indicate that the gut microbiota serves as an alternative source of these amines. Herein, we show five prominent genera Firmicutes (Blautia, Clostridium, Enterococcus, Ruminococcus, and Tyzzerella) ability abundantly produce through action amino acid decarboxylase (AADC). In vitro cultivation human fecal samples revealed a significant...
Host antitumor immune responses may be different between hepatocellular carcinoma (HCC) caused by metabolic disorders and HCC associated with hepatitis virus infection. In this study, we examined the response of tumor‐associated antigen (TAA)–specific T cells cell profile in patients separated cause. Thirty‐two B (HBV)–related HCC, 42 C virus–related 18 nonalcoholic steatohepatitis (NASH)–related were analyzed. The frequencies TAA‐specific cells, expression levels surface markers on each...
Abstract The behaviors and fates of immune cells in cancer patients, such as dysfunction stem-like states leading to memory formation T cells, are intense focus investigation. Here we show, by post hoc analysis peripheral blood lymphocytes hepatocellular carcinoma patients previously undergoing vaccination with tumour-associated antigen-derived peptides our clinical trials (registration numbers UMIN000003511, UMIN000004540, UMIN000005677, UMIN000003514 UMIN000005678), that induced...
Several chemokines are used for immunotherapy against cancers because they can attract immune cells such as dendritic and cytotoxic T to augment responses. Radiofrequency ablation (RFA) is locally eliminate hepatocellular carcinoma (HCC), renal cell carcinoma, lung cancer. Because HCC often recurs even after an eradicative treatment with RFA, additional necessary. We treated tumor-bearing mice by administering ECI301, active variant of CC chemokine ligand 3, RFA. Mice were injected s.c. BNL...
Whether or not pancreaticobiliary maljunction (PBM) is a risk factor for pancreatic cancer (PC) unclear. We present case of metachronous PC with PBM diagnosed after cholecystectomy gallbladder cancer, in which follow-up imaging was possible until onset. A 63-year-old man who had been and undergone 5 years earlier developed pancreatitis. Pancreatography revealed PBM, duct brush cytology adenocarcinoma. On reviewing the images, morphological abnormalities, observed before cholecystectomy, were...
The identification of effective diagnostic and prognostic biomarkers is critical to improving the outcomes patients with pancreatic ductal adenocarcinoma (PDAC). We explored potential serum levels laminin γ2 monomer (LG2m) as a biomarker in PDAC. This study included two cohorts. Cohort 1 142 PDAC patients, 55 intraductal papillary mucinous neoplasm (IPMN), 46 healthy individuals. 2 518 patients. medical records were reviewed. Cut-off for LG2m determined by receiver operating characteristic...
Mint3 enhances aerobic ATP production with subsequent nuclear translocation of hypoxia-inducible factor-1 (HIF-1) and activation angiogenesis-related genes. It remains unclear if when is activated whether it involved in hepatocarcinogenesis. We explored the expression surgically resected hepatocellular carcinoma (HCC) tissues. evaluated effects knockdown on spheroid formation capacity subcutaneous tumor growth immune-deficient mice. used knockout mice to evaluate chemically induced HCC...
Photodynamic therapy (PDT) with talaporfin sodium shows promise as a salvage treatment for locoregional recurrence of esophageal cancer after chemoradiotherapy (CRT). However, its application in cervical is limited due to anatomical challenges, such the restricted maneuverability standard endoscopes and difficulty achieving stable perpendicular laser irradiation. This study introduces modified PDT technique using thin endoscope customized attachment lesion stabilization precise targeting....
Inflammation plays a critical role in cancer. The aim of the present study was to investigate impact neutrophil lymphocyte ratio (NLR) on patients with advanced hepatocellular carcinoma (HCC) treated hepatic arterial infusion chemotherapy (HAIC).We retrospectively evaluated 266 HCC HAIC between March 2003 and December 2012. NLR calculated from differential leukocyte count by dividing absolute count.The cut-off level set as median value 2.87 among all this study. objective response rate low...
Dendritic cells (DCs) are antigen‐presenting with a central role in host immune response. This study analyzed gene expression and DC function hepatitis B virus (HBV) patients, functions impaired because of HBV, identified the genes related to these functions. Peripheral blood mononuclear from 64 HBV patients 19 healthy controls were analyzed. DCs stained antibodies against human leukocyte antigen–DR/Lin‐1/CD123/CD11c separated into plasmacytoid (pDCs) myeloid by fluorescence‐activated cell...
Backgrounds and Aims Structural dynamics of basement membrane components are still to be elucidated in the process hepatocarcinogenesis. We evaluated characteristics HCC expressing laminin γ2 monomer (LG2m), a component not detected normal tissues, for diagnosis. further determined whether elevated serum LG2m is risk factor development patients with chronic hepatitis C (CHC). Approach Results In cell lines, was expressed alpha‐fetoprotein (AFP)‐negative, CD90‐positive cells characterized by...
Overuse of antibiotic drugs alters the composition gut microbiota and has detrimental effects on host. In our study, we investigated association flora antibiotics in prognosis patients with liver cancer who have undergone chemotherapy by analyzing two independent clinical studies. We retrospectively subanalyzed a previously reported randomized controlled trial (RCT) hepatic arterial infusion hepatocellular carcinoma (HCC) to investigate between use prognosis. other prospectively determined...
Certain existing prebiotics meant to facilitate the growth of beneficial bacteria in intestine also promote other prominent bacteria. Therefore, growth-promoting effects β-galactosides on intestinal were analyzed. Galactosyl-β1,4-l-rhamnose (Gal-β1,4-Rha) selectively promoted Bifidobacterium. Bifidobacterium longum subsp. 105-A (JCM 31944) has multiple solute-binding proteins belonging ATP-binding cassette transporters for sugars. Each strain library 11 B. mutants, which each gene protein...
The malignant nature of hepatocellular carcinoma (HCC) is closely related to the presence cancer stem cells (CSCs). Bone morphologic protein 9 (BMP9), a member transforming growth factor-beta (TGF-β) superfamily, was recently reported be involved in liver diseases including cancer. We aimed elucidate role BMP9 signaling HCC-CSC properties and assess therapeutic effect BMP receptor inhibitors HCC. have identified that high expression tumor tissues or serum from patients with HCC leads poorer...