A5059485526- Liver Disease Diagnosis and Treatment
- Semiconductor materials and devices
- Advancements in Semiconductor Devices and Circuit Design
- Hepatitis C virus research
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver physiology and pathology
- Immune cells in cancer
- Low-power high-performance VLSI design
- Hepatitis B Virus Studies
- Pancreatic and Hepatic Oncology Research
- Virus-based gene therapy research
- Immune Cell Function and Interaction
- Semiconductor materials and interfaces
- Semiconductor Quantum Structures and Devices
- Integrated Circuits and Semiconductor Failure Analysis
- Chalcogenide Semiconductor Thin Films
- Liquid Crystal Research Advancements
- Biofuel production and bioconversion
- Mesenchymal stem cell research
- Wastewater Treatment and Nitrogen Removal
- Cytokine Signaling Pathways and Interactions
- Silicon and Solar Cell Technologies
- Advanced Semiconductor Detectors and Materials
Kanazawa University
2016-2025
Kanazawa University Hospital
2014-2024
Takara (Japan)
2020
Yokufukai Hospital
2017
Takashimadaira Chuo General Hospital
2013-2014
University of Yamanashi
2012-2014
Nihon University
2013
Nihon Kohden (Japan)
2013
Sanyo-Onoda City University
1996-2012
Kanazawa Medical University
2012
It has been shown that the pyrolysis of cellulose at low pressure (1.5 Torr) can be described by a three reaction model. In this model, it is assumed an "initiation reaction" leads to formation "active cellulose" which subsequently decomposes two competitive first-order reactions, one yielding volatiles and other char gaseous fraction. Over temperature range 259–341°C, rate constants these ki (for → cellulose"), kv "volatiles"), kc + fraction) are given = 1.7 × 1021e− (58,000/RT) min −1, 1.9...
MicroRNA (miRNA) plays an important role in the pathology of various diseases, including infection and cancer. Using real-time polymerase chain reaction, we measured expression 188 miRNAs liver tissues obtained from 12 patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) 14 C (HCV)-related HCC, background normal nine patients. Global gene same was analyzed via complementary DNA microarray to examine whether differentially expressed could regulate their target genes....
Abstract Vacuum pyrolysis of cellulose within the temperature range 300–500°C provides a tar fraction containing mainly levoglucosan and glucose condensation products. It was found that proceeds at much faster rate higher temperatures without detrimental effect on yields. At 400°C reaction essentially complete 3 min yielding contained 39% and, upon mild acid hydrolysis, gave 49% D‐glucose. The yields could be further improved by washing or treatment cellulosic substrates with acids. Cotton...
The replication and infectivity of the lipotropic hepatitis C virus (HCV) are regulated by cellular lipid status. Among differentially expressed microRNAs (miRNAs), we found that miR-27a was preferentially in HCV-infected liver over B (HBV)-infected liver. Gene expression profiling Huh-7.5 cells showed regulates metabolism targeting synthetic transcription factor RXRα transporter ATP-binding cassette subfamily A member 1. In addition, repressed many metabolism-related genes, including FASN,...
Many tumor-associated antigens (TAAs) recognized by cytotoxic T cells (CTLs) have been identified during the last two decades and some of them used in clinical trials. However, there are very few field immunotherapy for hepatocellular carcinoma (HCC) because not comparative data regarding CTL responses to various TAAs. In present study, using 27 peptides derived from 14 different TAAs, we performed analysis TAA-specific T-cell 31 HCC patients select useful examined factors that affect immune...
High speed photodiodes with semitransparent film-semiconductor junctions, which behave as Schottky barriers, are designed and prepared. The optimized width of the depletion layer photodiode is calculated for selected cut-off frequency. relations between transmittance sheet resistivity studied some films semiconducting compounds, affect gain response time photodiodes. photodiodes, fabricated by deposition CdS or CU 2 Se on Si, have high frequency Cu Se-n.Si higher than 4 GHz.
Recent metagenomic analyses have revealed dysbiosis of the gut microbiota ulcerative colitis (UC) patients. However, impacts this are not fully understood, particularly at strain level.We perform whole-genome shotgun sequencing fecal DNA extracts from 13 healthy donors and 16 UC 8 Crohn's disease (CD) The CD patients is taxonomically functionally divergent that donors, with E. faecium being most differentially abundant species between two microbial communities. Transplantation feces or into...
Cirrhosis is a chronic liver disease that impairs hepatic function and causes advanced fibrosis. Mesenchymal stem cells have gained recent popularity as regenerative therapy since they possess immunomodulatory functions. We found injected adipose tissue-derived (ADSCs) reside in the liver. Injection of ADSCs also restores albumin expression parenchymal ameliorates fibrosis nonalcoholic steatohepatitis model cirrhosis mice. Gene analysis identifies up- down-regulation genes, indicating...
Background. Although nucleos(t)ide analog (NA) therapy effectively reduces the hepatitis B virus (HBV) DNA load in serum of patients with chronic B, it does not completely reduce incidence hepatocellular carcinoma (HCC).
Background Pancreatic ductular adenocarcinoma (PDAC) is among the most dreadful of malignancies, in part due to lack efficacious chemotherapy. Immune checkpoint inhibitors, including anti-programmed cell death 1 (anti-PD-1) antibodies, are novel promising forms systemic immunotherapy. In current study, we assessed whether gemcitabine (GEM) combined with anti-PD-1 antibody treatment was as immunochemotherapy for advanced PDAC using a murine model liver metastasis. Methods The metastasis...
The authors have presented a new concept of excess sludge elimination treatment with recirculation via ozonation in the activated process. This paper is intended to clarify potential application process municipal and industrial wastewater treatments. In full-scale operational experiment lasting 10 months under 550 kg/d BOD loading, no was needed be withdrawn significant accumulation inorganic solids occurred aeration tank. Most compounds were released soluble phase. Material balance...
An activated sludge process which produces no excess was developed. The is very simple as a small amount of return ozonated and then returned to the aeration tank. ozonation enhances biodegradability sludge, biologically oxidized in A full-scale plant for treating 450m 3 /d municipal wastewater constructed has been operated successfully 9 months. eliminated directly proportional ozone dosed sludge. At dosing rate 0.034 kg/kg-SS, complete elimination achieved when 4 times more than that...
Journal Article Hydrolysis Rate of Pentosan Hardwood in Dilute Sulfuric Acid Get access Tatsuyoshi Kobayashi, Kobayashi Faculty Agriculture, Tokyo University Education Search for other works by this author on: Oxford Academic Google Scholar Yoshio Sakai Bulletin the Agricultural Chemical Society Japan, Volume 20, Issue 1, 1 January 1956, Pages 1–7, https://doi.org/10.1080/03758397.1956.10857296 Published: 01 1956 history Received: 08 October 1955
Although sorafenib is a standard drug for advanced hepatocellular carcinoma (HCC), little known about patient's clinical course after treatment. We investigated the effect of post-progression survival (PPS) and progression-free (PFS) on overall (OS) in patients whose HCC was treated by sorafenib.We searched PubMed database reports with data monotherapy, selected 20 or more each that provided both OS PFS time to progression (TTP). Median PPS (mPPS) defined as period obtained subtracting...
Adipose tissue stromal cells contain a substantial number of mesenchymal stem cells. As such, their application to regeneration miscellaneous impaired organs has attracted much attention. We designed clinical study investigate freshly isolated autologous adipose tissue-derived stromal/stem (regenerative) cell (ADRC) therapy for liver cirrhosis and conducted treatment in four cirrhotic patients. ADRCs were from subcutaneous obtained by the liposuction method, followed with use Celution system...
// Kai Takegoshi 1 , Masao Honda 1, 2 Hikari Okada Riuta Takabatake Naoto Matsuzawa-Nagata 3 Jean S. Campbell 4 Masashi Nishikawa Tetsuro Shimakami Takayoshi Shirasaki Yoshio Sakai Taro Yamashita Toshinari Takamura Takuji Tanaka 5 Shuichi Kaneko Department of Gastroenterology, Kanazawa University Graduate School Medicine, Kanazawa, Japan Advanced Medical Technology, Health Disease Control and Homeostasis, Pathology, Washington Seattle, WA, USA The Tohkai Cytopathology Institute: Cancer...
Hyperuricemia drives the development of nonalcoholic fatty liver disease (NAFLD). Pharmacological inhibition xanthine oxidase (XO), a rate-limiting enzyme for uric acid (UA) production, has been demonstrated to improve hepatic steatosis in diet-induced obese mice. However, it remains unclear whether XO improves steatohepatitis (NASH), more advanced form NAFLD, terms both inflammation and fibrosis. Here, we investigated effects febuxostat allopurinol, two inhibitors clinically used gout, on...
Abstract It remains unclear how hepatic steatosis links to inflammation. Leukocyte cell-derived chemotaxin 2 (LECT2) is a hepatokine that senses fat in the liver and upregulated prior weight gain. The aim of this study was investigate significance LECT2 development nonalcoholic steatohepatitis (NASH). In human biopsy samples, elevated mRNA levels were positively correlated with body mass index (BMI) increased patients who have inflammation liver. also inflammatory genes CCR2 TLR4 . C57BL/6J...
Abstract The behaviors and fates of immune cells in cancer patients, such as dysfunction stem-like states leading to memory formation T cells, are intense focus investigation. Here we show, by post hoc analysis peripheral blood lymphocytes hepatocellular carcinoma patients previously undergoing vaccination with tumour-associated antigen-derived peptides our clinical trials (registration numbers UMIN000003511, UMIN000004540, UMIN000005677, UMIN000003514 UMIN000005678), that induced...
Little slime layer was found to exist on the walls of sewer pipes in an anaerobic condition when sewage flow rate higher than approximately 30 cm/sec. Therefore, H2S is not produced from layers but sediments which existed main trunk or pressure main. The production rates ranged 5.5 64 pg-H2S/g·solid h depending contents organic compounds and cell numbers sulfate reducing bacteria (SRB). limiting nutrients are assumed be fatty acids by spike test. pipe wall area just above level corroded...
Low-temperature (77K, 4.2K) operation is proposed for bulk CMOS devices to be used in superfast VLSI applications. Symmetrical variation of the parameters both n-channel and p-channel MOSFETs with respect temperature latch-up immunity makes a very promising device technology at low temperatures. To demonstrate performance advantage circuit temperatures, inverter chains 16-kb static random-access memories (RAMs) 2-/spl mu/m gate length were measured. Average propagation delay an chain has...