A5082644268- Adipose Tissue and Metabolism
- Selenium in Biological Systems
- Liver Disease Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Cancer, Hypoxia, and Metabolism
- Muscle metabolism and nutrition
- Receptor Mechanisms and Signaling
- Hormonal Regulation and Hypertension
- Muscle Physiology and Disorders
- Regulation of Appetite and Obesity
- Ubiquitin and proteasome pathways
- Pancreatic function and diabetes
- Adrenal and Paraganglionic Tumors
- Mitochondrial Function and Pathology
- Adipokines, Inflammation, and Metabolic Diseases
- Renin-Angiotensin System Studies
- Protein Kinase Regulation and GTPase Signaling
- Diet, Metabolism, and Disease
- Cholesterol and Lipid Metabolism
- Peroxisome Proliferator-Activated Receptors
- Lipid metabolism and biosynthesis
- Biochemical Analysis and Sensing Techniques
- Bone Metabolism and Diseases
- MicroRNA in disease regulation
- Endoplasmic Reticulum Stress and Disease
National Center for Geriatrics and Gerontology
2007-2025
Kanazawa University
2015-2025
Kanazawa Medical University
2025
University of Tsukuba
2000-2016
Suzuki (Japan)
2011
The University of Tokyo
2006-2011
Fundación Juan March
2001
ABSTRACT The osteoclast is a giant cell that resorbs calcified matrix by secreting acids and collagenolytic enzymes. molecular mechanisms underlying metabolic adaptation to the increased biomass energetic demands of osteoclastic bone resorption remain elusive. Here we show during osteoclastogenesis expression both glucose transporter 1 (Glut1) glycolytic genes increased, whereas knockdown hypoxia-inducible factor 1-alpha (Hif1α), as well deprivation, inhibits bone-resorbing function...
Nonalcoholic steatohepatitis (NASH) is associated with obesity and type 2 diabetes, an increased risk for liver cirrhosis cancer. ELOVL family member 6, elongation of very long chain fatty acids (Elovl6), a microsomal enzyme that regulates the C12-16 saturated monounsaturated (FAs). We have shown previously Elovl6 major target sterol regulatory element binding proteins in it plays critical role development obesity-induced insulin resistance by modifying FA composition. To further investigate...
Abstract It remains unclear how hepatic steatosis links to inflammation. Leukocyte cell-derived chemotaxin 2 (LECT2) is a hepatokine that senses fat in the liver and upregulated prior weight gain. The aim of this study was investigate significance LECT2 development nonalcoholic steatohepatitis (NASH). In human biopsy samples, elevated mRNA levels were positively correlated with body mass index (BMI) increased patients who have inflammation liver. also inflammatory genes CCR2 TLR4 . C57BL/6J...
Transcriptional regulation of metabolic genes in the liver is key to maintaining systemic energy homeostasis during starvation. The membrane-bound transcription factor cAMP-responsive element-binding protein 3-like 3 (CREB3L3) has been reported be activated fasting and regulate triglyceride metabolism. Here, we show that CREB3L3 confers a wide spectrum responses starvation vivo. Adenoviral transgenic overexpression nuclear induced lipolysis, hepatic ketogenesis, insulin sensitivity with...
Glucose lowering independently reduces liver fibrosis in human NAFLD. We investigated the impact of diabetes on steatohepatitis and established a novel mouse model for diabetic steatohepatitis.Male C57BL/6J mice were fed 60% high-fat diet (HFD) injected with carbon tetrachloride (CCl4) streptozotocin (STZ) to induce diabetes. The HFD+CCl4+STZ group displayed more severe steatosis, hepatocyte ballooning, regenerative nodules compared other groups. Diabetes upregulated inflammatory...
Abstract Type 2 diabetes is known as a heterogeneous disease with diverse pathophysiology. The identification of treatment effect modifiers for personalized medicine, however, has been difficult in basic research due to complex biological mechanisms related various genetic and nongenetic factors, clinical confounding bias limited sample sizes. In this paper, we focus on two-sequence, two-period crossover (CO) trial type baseline markers new strategy analyzing modification that allows...
Sunitinib is an oral multitargeted receptor tyrosine kinase inhibitor with antiangiogenic and antitumor activity that mainly targets vascular endothelial growth factor receptors (VEGFRs). Very recently, sunitinib has been shown to be active agent for the treatment of malignant pheochromocytomas. However, it unclear whether acts only through mechanism or may also directly target tumor cells. markedly induced apoptosis PC12 cells in a dose-dependent time-dependent manner. Furthermore, support...
Objective— Sterol regulatory element–binding protein-1 (SREBP-1) is nutritionally regulated and known to be a key transcription factor regulating lipogenic enzymes. The goal of this study was evaluate the roles SREBP-1 in dyslipidemia atherosclerosis. Methods Results— Transgenic mice that overexpress SREBP-1c liver SREBP-1-deficient were crossed with low-density lipoprotein receptor (LDLR)–deficient mice, plasma lipids atherosclerosis analyzed. Hepatic overexpression LDLR-deficient caused...
Reactive oxygen species (ROS) activate uncoupler protein 1 (UCP1) in brown adipose tissue (BAT) under physiological cold exposure and noradrenaline (NA) stimulation to increase thermogenesis. However, the endogenous regulator of ROS activated BAT its role pathological conditions remain unclear. We show that serum levels selenoprotein P (SeP; encoded by SELENOP) negatively correlate with activity humans. Physiological downregulates Selenop BAT. knockout mice higher rectal temperatures UCP1...
Dieting often leads to body weight cycling involving repeated loss and regain. However, little information is available regarding rapid-response serum markers of overnutrition that predict alterations during cycling. Here, we report the rapid response leukocyte cell-derived chemotaxin 2 (LECT2), a hepatokine induces insulin resistance in skeletal muscle, diet-induced mice. A switch from high-fat diet (HFD) regular (RD) obese mice gradually decreased but rapidly LECT2 levels within 10 days....
We have previously shown that murine recombinant leptin directly stimulates catecholamine synthesis through the long form of receptor (Ob-Rb) expressed in cultured porcine chromaffin cells. Additionally, we found activates IP3 production after PLC activation. It is well established activation elicits as an increase diacylglycerol, a compound PKC. Therefore, investigated involvement PKC leptin-induced synthesis. Leptin was to induce significant increases activity dose-dependent manner (1, 10,...
Elovl6, a long-chain fatty acid elongase, is rate-limiting enzyme that elongates saturated and monounsaturated acids has been shown to be related obesity-induced insulin resistance via modification of composition. In this study, we investigated the roles Elovl6 in foam cell formation macrophages atherosclerosis mice.To investigate progression atherosclerosis, transplanted bone marrow cells wild-type or Elovl6(-/-) mice into irradiated LDL-R(-/-) were fed western diet. Aortic atherosclerotic...
The role of transcription factor E3 (TFE3), a bHLH factor, in immunology and cancer has been well characterized. Recently, we reported that TFE3 activates hepatic IRS-2 hexokinase, participates insulin signaling, ameliorates diabetes. However, the effects other organs are poorly understood. Herein, examined on skeletal muscle, an important organ involved glucose metabolism. We generated transgenic mice selectively express muscles. These exhibit slight acceleration growth prior to adulthood...