A5053378428- Statistical Methods in Clinical Trials
- Structural Behavior of Reinforced Concrete
- Gene expression and cancer classification
- Structural Load-Bearing Analysis
- Colorectal Cancer Treatments and Studies
- Cancer Genomics and Diagnostics
- Health Systems, Economic Evaluations, Quality of Life
- Statistical Methods and Inference
- Genetic factors in colorectal cancer
- Structural Engineering and Vibration Analysis
- Optimal Experimental Design Methods
- Ovarian cancer diagnosis and treatment
- Innovative concrete reinforcement materials
- Advanced Causal Inference Techniques
- Orthodontics and Dentofacial Orthopedics
- Concrete Corrosion and Durability
- Cardiac Arrest and Resuscitation
- Genetic Associations and Epidemiology
- Computational Drug Discovery Methods
- Statistical Methods and Bayesian Inference
- Radiomics and Machine Learning in Medical Imaging
- Dental Implant Techniques and Outcomes
- Bioinformatics and Genomic Networks
- Sepsis Diagnosis and Treatment
- Endometrial and Cervical Cancer Treatments
Nagoya University
2016-2025
The Institute of Statistical Mathematics
2009-2025
Japan Science and Technology Agency
2016-2025
Nagoya University Hospital
2015-2023
Lund University
2023
Ministry of Education, Culture, Sports, Science and Technology
2022
Osaka Institute of Technology
2009-2020
Aichi University
2019
Shizuoka Prefecture Agricultural and Forestry Research Institute
2018
Pharmaceuticals and Medical Devices Agency
2014-2018
Although vascular endothelial growth factor (VEGF) is a primary mediator of retinal angiogenesis, VEGF inhibition alone insufficient to prevent neovascularization. Hence, it postulated that there are other potent ischemia-induced angiogenic factors. Erythropoietin possesses activity, but its potential role in ocular angiogenesis not established.We measured both erythropoietin and levels the vitreous fluid 144 patients with use radioimmunoassay enzyme-linked immunosorbent assay. Vitreous...
Denosumab 60 mg sc injection every 6 months for 36 was well tolerated and effective in reducing the incidence of vertebral, nonvertebral, hip fracture predominantly Caucasian postmenopausal women with osteoporosis.The objective this phase 3 study to examine antifracture efficacy safety denosumab Japanese men osteoporosis compared placebo.A randomized, double-blind, placebo-controlled trial an open-label active comparator as a referential arm conducted.Subjects were 1262 patients aged 50...
The International Union Against Cancer highlighted tumor budding as a tumor-related prognostic factor. assessment criteria for were recently defined by the 2016 Tumor Budding Consensus Conference (ITBCC2016). This study aimed to clarify and predictive values of in randomized controlled trial evaluating superiority adjuvant chemotherapy with oral tegafur-uracil over surgery alone stage II colon cancer (SACURA trial; ClinicalTrials.gov identifier: NCT00392899).
Occurrence of delirium in the ICU is associated with a longer stay ICU. To examine whether use ramelteon, melatonin agonist, can prevent and shorten duration critically ill patients.A single-center, triple-blinded, randomized placebo-controlled trial.ICU an academic hospital.Eligible patients were who could take medicines orally or through nasogastric tube during first 48 hours admission.The intervention group received ramelteon (8 mg/d), control placebo (1 g/d lactose powder) at 20:00 every...
Univariate feature selection is one of the simplest and most commonly used techniques to develop a multigene predictor for survival. Presently, there no software tailored perform univariate construction. We compound.Cox R package that implements significance tests (via Wald or score tests) selection. provide cross-validation algorithm measure predictive capability selected genes permutation assess false discovery rate. also three algorithms constructing (compound covariate, compound...
Increases in sodium concentrations ([Na+]) body fluids elevate blood pressure (BP) by enhancing sympathetic nerve activity (SNA). However, the mechanisms which information on increased [Na+] is translated to SNA have not yet been elucidated. We herein reveal that activation leading BP increases induced mandatory high salt intakes or intraperitoneal/intracerebroventricular infusions of hypertonic NaCl solutions Nax-knockout mice contrast wild-type mice. identify Nax channels expressed...
OBJECTIVES: The optimal target temperature during targeted management for patients after cardiac arrest remains under debate. aim of this study was to evaluate the association between at lower temperatures and neurologic outcomes among classified by severity postcardiac syndrome. DESIGN: A multicenter observational from out-of-hospital registry Japanese Association Acute Medicine, which is a nationwide prospective patients. SETTING: total 125 critical care medical centers or hospitals with...
Abstract Background The characterisation of desmoplastic reaction (DR) has emerged as a new, independent prognostic determinant in colorectal cancer. Herein, we report the validation its value randomised controlled study (SACURA trial). Methods included 991 stage II colon cancer patients. DR was classified by central review Mature, Intermediate or Immature based on presence hyalinised collagen bundles and myxoid stroma at front. All clinical pathological data, including characterisations,...
Aim: The POSITIVE study assessed whether long-term treatment with probucol. a potent anti-oxidant and cholesteryl ester transfer protein (CETP) activator is associated lowered risk of cardiovascular events in very high-risk population: familial hypercholesterolemia (FH).Methods: cohort included 410 patients heterozygous FH, diagnosed between 1984 1999 by metabolic experts at fifteen centers. Traceable were screened using predefined eligibility criteria. primary outcome measure for comparison...
Conclusion: An epidemiological survey of hospitals and private clinics in Japan regarding idiopathic sudden sensorineural hearing loss (SSNHL) revealed that the incidence SSNHL was 60.9 per 100 000 population. There were more females than males younger generation. Objective: The varies largely by country. Because Japanese criteria for diagnosing have changed accordance with those widely used other parts world, a clinicoepidemiological study undertaken using new criteria. Methods: Ehime,...
Motile cilia in ependymal cells, which line the cerebral ventricles, exhibit a coordinated beating motion that drives directional cerebrospinal fluid (CSF) flow and guides neuroblast migration. At apical cortex of these multi-ciliated asymmetric localization planar cell polarity (PCP) proteins is required for polarization microtubule dynamics, coordinates orientation. Daple disheveled-associating protein controls non-canonical Wnt signaling pathway motility. Here, we show Daple-deficient...
To investigate the diurnal variations of ocular blood flow in healthy eyes using laser speckle flowgraphy (LSFG), and to determine relationship between other parameters.This prospective cross-sectional study was conducted at Nagoya University Hospital. We studied 13 volunteers whose mean age 33.5 ± 7.6 years. The blur rate (MBR), expressing relative flow, on optic nerve head (ONH) choroidal determined by LSFG (LSFG-NAVI) every 3 hours from 6:00 24:00 hours. intraocular pressure (IOP),...
Purpose: The purpose of this study was to evaluate foveal regeneration and the association between retinal restoration visual acuity following reattachment surgery for rhegmatogenous detachment (RRD). Methods: Twenty-nine eyes 29 patients with successfully reattached macula-off RRD were retrospectively analyzed. We used spectral-domain optical coherence tomography image macular regions measure thickness Snellen chart (VA) best-corrected VA (BCVA) at 1, 2, 3, 6, 9, 12 months after vitrectomy....
Spermatogenesis is dependent on a small population of stem cells. Although cells are believed to expand infinitely, there little functional evidence regarding whether spermatogonial can increase in their number. Using the transplantation technique, we evaluated proliferative potential two models regeneration. After busulfan injection deplete cells, surviving were able by at least 15.8-fold within 2 mo. On other hand, serial study indicated that one transplanted cell was 3.8- and 12-fold 4...
Intracranial revascularization surgeries are an effective treatment for moyamoya disease and other intracranial vascular obliterative diseases. However, in some cases, wound-related complications develop after surgery. Although the incidence of wound complication is supposed to be higher than that with a usual craniotomy, this has rarely been focus studies literature report outcomes surgeries. Here, relationship between their statistically assessed.Between October 2004 February 2010, 71...
Purpose: To evaluate sex-related differences in ocular blood flow of healthy subjects using laser speckle flowgraphy (LSFG). Methods: In this prospective cross-sectional study, we examined 103 volunteers (47 males, 56 females; mean age: 39.3 ± 15.6 years and 42.1 18.7 years, respectively). The to the optic nerve head (ONH) choroid was assessed with LSFG, including blur rate (MBR) pulse waveform variables. We evaluated these variables compared them those other clinical parameters. Results: A...
Summary Thoracic interfascial plane blocks are effective for post‐mastectomy acute analgesia. However, their effects on chronic pain uncertain. We randomly allocated 80 women equally to pectoral nerve‐2 (PECS 2) block or serratus block. The reduced the rate of moderate severe from 13/40 (33%) with 4/40 (10%), p = 0.03, adjusted odds ratio (95%CI) 0.23 (0.07–0.80), 0.02. rates pain‐free at six postoperative months were indeterminate, 10/40 (25%) after vs. 19/40 (48%) block, 0.06, 2.9...
The efficacy of low-dose lansoprazole has not been established for the prevention recurrent gastric or duodenal ulcers in those receiving long-term aspirin (LDA) cardiovascular and cerebrovascular protection. This study sought to examine (15 mg once daily) secondary LDA-associated ulcers.Patients were randomized receive 15 daily (n = 226) gefarnate 50 twice 235) 12 months longer a prospective, multicenter, double-blind, active-controlled trial, followed by 6-month follow-up with open-label...