A5101609688- Bone health and osteoporosis research
- Bone health and treatments
- Bone Metabolism and Diseases
- Bone and Joint Diseases
- Medical Imaging and Pathology Studies
- Medical Imaging Techniques and Applications
- Parathyroid Disorders and Treatments
- Vitamin D Research Studies
- Hip and Femur Fractures
- Radiopharmaceutical Chemistry and Applications
- Body Composition Measurement Techniques
- Vitamin K Research Studies
- Advanced MRI Techniques and Applications
- Nitric Oxide and Endothelin Effects
- MRI in cancer diagnosis
- Nutrition and Health in Aging
- Radiation Dose and Imaging
- Vector-borne infectious diseases
- Medical Imaging and Analysis
- Hip disorders and treatments
- Advanced X-ray and CT Imaging
- Antioxidant Activity and Oxidative Stress
- Bone Tumor Diagnosis and Treatments
- Viral Infections and Vectors
- Thyroid Cancer Diagnosis and Treatment
Kawasaki Medical School
2012-2023
Okayama University
2016-2017
Nihon University
2017
Tohoku University
2010-2017
Jikei University School of Medicine
1993-2014
Waseda University
2002-2010
Kyoto University
1976-2007
Kawasaki Medical School Hospital
2006
Osaka University
1979-2004
Kagawa University
2003-2004
8-epi-prostaglandin F2 alpha (8-epi-PGF2 alpha) and related compounds are novel prostanoid produced by a noncyclooxygenase mechanism involving lipid peroxidation. Renal ischemia-reperfusion injury increased urinary excretion of these 300% over baseline level. Intrarenal arterial infusion at 0.5, 1, 2 micrograms/kg per min induced dose-dependent reductions in glomerular filtration rate (GFR) renal plasma flow, with function ceasing the highest dose. Micropuncture measurements (0.5...
In 1998, the first Japanese practice guidelines on osteoporosis was published. It has been updated several times, with most recent being full-scale 2011 edition and its abridged edition. The present provide information for managements of primary in postmenopausal women men over 50 years old, a summary evidence treatment secondary osteoporosis, prevention younger people.The Executive Summary is primarily based content One key changes revision criteria initiation pharmacological treatment,...
Weekly teriparatide injection at a dose of 56.5 μg has been shown to increase bone mineral density.A phase 3 study was conducted determine the efficacy once-weekly for reducing incidence vertebral fractures in patients with osteoporosis.In this randomized, multicenter, double-blind, placebo-controlled trial Japan, morphological by radiographs assessed.Subjects were 578 Japanese between ages 65 and 95 yr who had prevalent fracture.Subjects randomly assigned receive s.c. injections (56.5 μg)...
The isoprostanes are nonenzymatically generated prostanoids synthesized in vivo humans and rats through reactions catalyzed by free oxygen radicals. 8-Epi-prostaglandin F2 alpha (8-epi-PGF2 alpha), an F2-isoprostane, is a potent smooth muscle constrictor. A thromboxane A2 (TxA2) receptor antagonist, SQ 29548, blocks renal vasoconstriction during 8-epi-PGF2 administration rats. With the use of cultured rat aortic cells, we found specific binding sites for [3H]SQ 29548 [125I]BOP, TxA2 agonist....
Abstract In a cohort of 2356 Japanese elderly, after adjusting for age and prevalent vertebral fracture, baseline BMD predicted the risk spine hip fracture with similar RR to that obtained from previous reports in whites. The per SD decrease declined age. Introduction: Low bone mineral density (BMD) is one most important predictors future fracture. However, we are not aware any among Japan. Materials Methods: We examined association or men women aged 47–95 years, who were followed up by...
Abstract Aim: To investigate the safety and efficacy of 52 weeks dienogest treatment in patients with endometriosis. Methods: One hundred thirty‐five endometriosis received 2 mg orally each day for weeks. Adverse drug reactions bone density were evaluated. Global improvement was assessed based on changes severity categories five subjective symptoms during non‐menstruation (lower abdominal pain, lumbago, dyschezia, dyspareunia, pain vaginal examination) two objective findings (induration...
Abstract Fibroblast growth factor 2 (FGF-2) is a potent mitogen for mesenchymal cells, and local application of recombinant human FGF-2 (rhFGF-2) in gelatin hydrogel has been reported to accelerate bone union our animal studies preparatory dose-escalation trial on patients with surgical osteotomy. We have performed randomized, double-blind, placebo-controlled which fresh tibial shaft fractures transverse or short oblique type were randomly assigned three groups receiving single injection the...
Eldecalcitol is an analog of 1,25-dihydroxyvitamin D(3) that improves bone mineral density; however, the effect eldecalcitol on risk fractures unclear. The objective this study to examine whether superior alfacalcidol in preventing osteoporotic fractures. This trial registered with ClinicalTrials.gov, number NCT00144456.This 3 year randomized, double-blind, active comparator, superiority tested efficacy daily oral 0.75 μg versus 1.0 for prevention 1054 patients 46 92 years old were randomly...
To retrospectively evaluate the influence of postbiopsy hemorrhage on accuracy tumor detection at T2-weighted magnetic resonance (MR) imaging, dynamic contrast material-enhanced MR and diffusion-weighted (DW) imaging prostate cancer, with histologic findings as reference standard.The institutional review board approved this study waived requirement for informed consent. Forty male patients aged 62-84 years (mean age, 71 years) who had cancer underwent gland after ultrasonographically (US)...
Denosumab 60 mg sc injection every 6 months for 36 was well tolerated and effective in reducing the incidence of vertebral, nonvertebral, hip fracture predominantly Caucasian postmenopausal women with osteoporosis.The objective this phase 3 study to examine antifracture efficacy safety denosumab Japanese men osteoporosis compared placebo.A randomized, double-blind, placebo-controlled trial an open-label active comparator as a referential arm conducted.Subjects were 1262 patients aged 50...
Abstract Long-term bed rest has potential risks of bone loss and renal stone formation. We examined the effects resistive exercise intravenous pamidronate on BMD, turnover, urinary calcium, formation in 25 healthy males during 90-day rest. Pamidronate prevented femoral formation, but showed little effects. Introduction: increases Resistive bisphosphonates reduce resorption. However, muscle have not been side-by-side. The objectives this study are to compare with BMD prolonged Materials...
Context: ED-71 has been shown to increase lumbar bone mineral density (BMD) in osteoporotic subjects. However, vitamin D insufficiency might have influenced the effect of on BMD. Objective: Our objective was examine whether can BMD patients under supplementation. Design, Setting, and Patients: We conducted a randomized, double-blind, placebo-controlled clinical trial 219 (49–87 yr age). Interventions: Subjects were randomly assigned receive placebo or 0.5, 0.75, 1.0 μg/d for 12 months. All...
SUMMARY; A randomized placebo-controlled trial was conducted to examine the effect of daily oral 1 mg minodronate on vertebral fractures in 704 postmenopausal women with established osteoporosis for 24 months. Minodronate treatment reduced by 59% without serious adverse events. is a safe and effective bisphosphonate treatment.Minodronate increases bone mineral density (BMD) osteoporotic patients. However, its efficacy reducing has not been tested.To anti-fracture safety osteoporosis,...
In a 2-year randomized, placebo-controlled study of 665 Japanese patients with primary osteoporosis, once-yearly administration zoledronic acid (5 mg) reduced the risk new morphometric vertebral fractures. The purpose this was to determine efficacy and safety intravenous infusion ZOL in osteoporosis. This two-year multicenter, placebo-controlled, double-blind, parallel-group comparative (ZONE Study). Subjects were between ages 65 89 years who had prevalent fracture. randomly assigned receive...