A5053597578- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Scoliosis diagnosis and treatment
- Cervical and Thoracic Myelopathy
- Pelvic and Acetabular Injuries
- Metallurgy and Material Forming
- Microstructure and mechanical properties
- Pain Mechanisms and Treatments
- Microstructure and Mechanical Properties of Steels
- Bone health and osteoporosis research
- Musculoskeletal pain and rehabilitation
- Ion channel regulation and function
- Neuroscience and Neuropharmacology Research
- Advanced Semiconductor Detectors and Materials
- Parkinson's Disease and Spinal Disorders
- Endometriosis Research and Treatment
- Nerve Injury and Rehabilitation
- Bone health and treatments
- Catalytic Processes in Materials Science
- Nutrition and Health in Aging
- Frailty in Older Adults
- Spinal Cord Injury Research
- Management of metastatic bone disease
- Semiconductor Quantum Structures and Devices
- Bone and Joint Diseases
Niigata University
2016-2025
Niigata University Medical and Dental Hospital
2016-2025
Yokohama National University
2024-2025
National Center for Global Health and Medicine
2024
Kitasato University
2022
Financial Research (Hungary)
2020
Rady Children's Hospital-San Diego
2020
Asahi Kasei (Japan)
2016
Niigata Prefectural Central Hospital
2010-2011
University of Fukui
2007
AbstractAbstractThe dislocation substructures developed during dynamic recrystallisation (DRX) were studied by means of tensile tests and metallographic observations on polycrystalline nickel. The average cell size in the homogeneous decreased rapidly with straining to about half peak strain, whereupon DRX nuclei began form. then approached a constant value for increasing strain. Full distributed heterogeneously throughout all areas, classifiable into three categories: (i) nuclei, (ii)...
In Brief Study Design. A prospective study. Objective. To evaluate the effectiveness of prophylactic C4/C5 microforaminotomy with open-door laminoplasty for cervical myelopathy in preventing postoperative C5 palsy. Summary Background Data. Postoperative palsy is a common complication laminoplasty. Although etiology and preventive measures remain unclear, we hypothesize that caused by nerve root impairment induced potential foraminal stenosis posterior shifting spinal cord after Methods. The...
In a 2-year randomized, placebo-controlled study of 665 Japanese patients with primary osteoporosis, once-yearly administration zoledronic acid (5 mg) reduced the risk new morphometric vertebral fractures. The purpose this was to determine efficacy and safety intravenous infusion ZOL in osteoporosis. This two-year multicenter, placebo-controlled, double-blind, parallel-group comparative (ZONE Study). Subjects were between ages 65 89 years who had prevalent fracture. randomly assigned receive...
Abstract Attenuation of the secondary injury spinal cord (SCI) can suppress spread tissue damage, possibly resulting in sparing that improve functional prognoses. Granulocyte colony-stimulating factor (G-CSF) is a haematological cytokine commonly used to treat neutropenia. Previous reports have shown G-CSF promotes recovery rodent models SCI. Based on preclinical results, we conducted early phase clinical trials, showing safety/feasibility and suggestive efficacy. These lines evidence...
BACKGROUND Spinal reconstruction of an L5 osteoporotic vertebral fracture (OVF) is a demanding surgery because the condition’s rarity, poor bone quality, and anatomical reasons. To date, there has been little debate regarding surgical strategy for OVF effective osteoporosis treatment. The authors report osteotomy adjuvant romosozumab (ROMO) therapy OVF–induced spinal deformity. OBSERVATIONS A 73-year-old woman underwent lumbopelvic instrumentation fusion from L3 to pelvis, combined with...
A retrospective study.To determine the clinical and imaging characteristics of postoperative C5 palsy after cervical open-door laminoplasty.Postoperative is a common complication laminoplasty, although there are several hypotheses regarding its etiology, pathogenesis preventive measures remain unidentified many controversies remain.A total 141 consecutive patients (100 men 41 women) who had undergone laminoplasty for myelopathy between 2006 2009 were included in this study. Postoperative was...
Study Design. A prospective multicenter study. Objective. To evaluate the effects of sparing lumbar motion segments on spinal mobility and Scoliosis Research Society-22 scores at 10 years after fusion for major thoracic adolescent idiopathic scoliosis (AIS). Summary Background Data. In surgical correction AIS, long-term benefits remain unclear. Methods. registry was reviewed patients with AIS (Lenke types 1–4) availability both preoperative 10-year postoperative data were included. Spinal...
Study Design. A retrospective, long-term follow-up study. Objective. We aimed to clarify the predicting factors at skeletal maturity for future curve progression and low back pain (LBP) in adolescent idiopathic scoliosis (AIS) with thoracolumbar/lumbar (TL/L) curve. Summary of Background Data. TL/L curves are likely progress after cause LBP. Methods. Of 147 patients treated nonoperatively AIS curve, 56 (55 females; average age time survey, 39.5 ± 7.1 years; duration maturity, 24.9 6.9 years)...
Study Design. A retrospective long-term follow-up study. Objective. To investigate the health-related quality of life (HRQOL) status in middle-aged patients with adolescent idiopathic scoliosis (AIS) treated non-surgically. Summary Background Data. The HRQOL using various established questionnaires for non-operated AIS has not been fully investigated surveys. Methods. Inclusion criteria were non-surgical treatment AIS, more than or equl to 30° major at skeletal maturity (Risser grade ≥4),...
Aims The aim of this study is to test the hypothesis that three grades sagittal compensation for standing posture (normal, compensated, and decompensated) correlate with health-related quality life measurements (HRQOL). Methods A total 50 healthy volunteers (normal), 100 patients single-level lumbar degenerative spondylolisthesis (LDS), 70 adult elderly spinal deformity (deformity) were enrolled. Following collection demographic data HRQOL measured by Scoliosis Research Society-22r...
Spinal cord injury (SCI) leads to the development of neuropathic pain. Although a multitude pathological processes contribute SCI-induced pain, excessive intracellular calcium accumulation and voltage-gated calcium-channel upregulation play critical roles in However, role blockers pain is unknown. Omega-conotoxin MVIIA (MVIIA) blocker that selectively inhibits N-type voltage-dependent channels demonstrates neuroprotective effects. Therefore, we investigated spinal analgesic actions cellular...
Poly(4-hydroxybutyl vinyl ether) [poly(HOBVE)] and the related copolymers, which showed thermally induced phase separation in water, are synthesized via living cationic copolymerization. When aqueous solution of copoly(HOBVE) is heated, coacervate droplets observed micrograph. This thermoresponsive copolymer exhibiting coacervation accompanied by liquid−liquid-phase separations though unlike precipitation. To obtain hydrogel microspheres from droplets, highly random copolymers HOBVE...
A retrospective case study of the use posterior lumbar interbody fusion (PLIF) to treat foraminal stenosis (LFS).To characterize features clinical symptoms, radiographic evaluation, and surgical outcomes PLIF in LFS.There is no gold standard for treatment stenosis, which occurs 8% 10% cases degenerative disease.Data from 31 patients (33 segments) who underwent 2001 2005 at our institution were analyzed. Exclusion criteria included having both LFS central canal plus extraforaminal or...
A prospective study.To evaluate the 2-year outcomes of open-door cervical laminoplasty with prophylactic bilateral C4-C5 foraminotomy.A trial foraminotomy for compression myelopathy showed a significant efficacy preventing postoperative C5 palsy. However, in foraminotomy, there are concerns such as instability, hinge fracture, or nonunion, which may cause deterioration neurological symptoms and neck pain.A was performed 141 patients between 2009 2010 (group F). group who underwent without...
Abstract Background The widely used analgesic acetaminophen is metabolized to N-acylphenolamine, which induces analgesia by acting directly on transient receptor potential vanilloid 1 or cannabinoid receptors in the brain. Although these are also abundant spinal cord, no previous studies have reported effects of N-acylphenolamine mediated cord dorsal horn. We hypothesized that clinical doses induce via mechanisms. Methods assessed our hypothesis a rat model using behavioral measures. vivo...
Retrospective case series.To investigate the oncological outcomes, including distant relapse, after en bloc spondylectomy (EBS) for spinal metastases in patients with a minimum of 2-year follow-up.Although EBS has been reported to be locally curative and extend survival select metastases, detailed reports regarding control relapse are lacking.We conducted retrospective review 18 consecutive (median age at EBS, 62 years; range, 40-77 years) who underwent between 1991 2015. The primary cancer...