A5018492979- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Cervical and Thoracic Myelopathy
- Intraoperative Neuromonitoring and Anesthetic Effects
- Nerve Injury and Rehabilitation
- Spinal Cord Injury Research
- Musculoskeletal pain and rehabilitation
- Peripheral Nerve Disorders
- Meningioma and schwannoma management
- Pelvic and Acetabular Injuries
- Management of metastatic bone disease
- Nerve injury and regeneration
- Pain Mechanisms and Treatments
- Spinal Hematomas and Complications
- Orthopedic Surgery and Rehabilitation
- Medical Imaging and Analysis
- Scoliosis diagnosis and treatment
- Shoulder Injury and Treatment
- Neurogenesis and neuroplasticity mechanisms
- Mesenchymal stem cell research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Transcranial Magnetic Stimulation Studies
- Stroke Rehabilitation and Recovery
- Veterinary Orthopedics and Neurology
- Hip and Femur Fractures
Yamaguchi University
2016-2025
Institute for Conflict Research
2024
Yamaguchi University Hospital
2024
Japan Organization of Occupational Health and Safety
2016
Low back pain (LBP) is the most common cause of chronic pain. Numerous clinical scales are available for evaluating pain, but their objective criteria in management LBP patients remain unclear. This study aimed to determine an cutoff value a change Pain Intensity Numerical Rating Scale (ΔPI-NRS) three months after treatment. Its utility was compared with changes six commonly used patients: Disability Assessment (PDAS), Self-Efficacy Questionnaire (PSEC), Catastrophizing (PCS), Athens...
Abstract Attenuation of the secondary injury spinal cord (SCI) can suppress spread tissue damage, possibly resulting in sparing that improve functional prognoses. Granulocyte colony-stimulating factor (G-CSF) is a haematological cytokine commonly used to treat neutropenia. Previous reports have shown G-CSF promotes recovery rodent models SCI. Based on preclinical results, we conducted early phase clinical trials, showing safety/feasibility and suggestive efficacy. These lines evidence...
Abstract Introduction Spinal cord injury (SCI) is a devastating and remains one of the largest medical social burdens because its intractable nature. According to recent advances in stem cell biology, possibility spinal regeneration functional restoration has been suggested by introducing appropriate cells. Multilineage-differentiating stress enduring (Muse) cells are type nontumorigenic endogenous reparative cell. The positive results Muse transplantation for SCI was shown previously. As...
Study Design. Retrospective analysis of data collected across multiple centers. Objective. To develop machine learning models for predicting neurological outcomes one month postoperatively in patients with metastatic spinal tumors undergoing surgery, and to identify key factors influencing recovery. Summary Background Data. The increasing prevalence metastases has led a growing need surgical intervention address mechanical instability deficits. Predicting postoperative status, as assessed by...
Study Design. Prospective multicenter study. Objective. To investigate risk factors for 3-month postoperative mortality in metastatic spinal tumor surgery, focusing on nutritional biomarkers and prognostic scores alongside clinical indicators. Summary of Background Data. Metastatic tumors affect patient morbidity mortality. Although tools exist, they have limitations, particularly emergency situations requiring rapid assessment. Nutritional may influence outcomes, but their role predicting...
Spinal compression fractures commonly occur at the thoracolumbar junction. We have previously constructed a 3-dimensional whole-spine model from medical images by using finite element method (FEM) and then used this to develop fracture model. However, these models lacked rib cage. No previous study has including cage analyze fractures. Therefore, in study, we added models. models, normal spine without cage, with fractures, FEM analysis. Then, simulated person falling on buttocks perform...
Study Design. Prospective, multicenter, observational study. Objective. The aim of this study was to investigate the efficacy intervention after an alert in intraoperative neurophysiological monitoring (IONM) using transcranial motor-evoked potentials (Tc-MEPs) during surgery for thoracic ossification posterior longitudinal ligament (T-OPLL). Summary Background Data. T-OPLL is commonly treated with decompression and fusion instrumentation. IONM Tc-MEPs reduces risk neurological...
Abstract The age-related degenerative pathologies of the cervical spinal column that comprise myelopathy (DCM) cause due cord compression. Functional neurological assessment DCM can potentially reveal severity and pathological mechanism DCM. However, functional by conventional MRI remains difficult. This study used resting-state (rs-fMRI) to investigate relationship between connectivity (FC) strength neurophysiological indices examined feasibility FC for Preoperatively, 34 patients with...
To investigate the effect on central motor conduction time (CMCT) based relationship between age and height in normal subjects.Retrospective study.One hundred ninety nine subjects (107 men 92 women; mean 39.0 ± 16.4 years; 164.5 8.8 cm) participated study. The approximate ages of were as follows: 82 (20-29 years old), 32 (30-39 (40-49 28 (50-59 25 (≧60 old). heights 9, 49, 79, 53, 9 <150 cm, 150-160 160-170 170-180 >180 respectively. CMCT- abductor digiti minimi (ADM) hallucis (AH)...
Vertebral fractures commonly occur at the thoracolumbar junction. These can be treated with mild residual deformity in many cases, but are reportedly associated increased risk of secondary vertebral fractures. In present study, a three‑dimensional (3D) whole spine model was constructed using finite element method to explore mechanism development compression The 3D spine, from cervical pelvis, computed tomography (CT) images an adult male. Using normal and models T11, T12 or L1 vertebrae,...
Objective: To evaluate neurologic findings caused by a single ossification of ligamentum fravum (OLF) and identify the level lumbar segment spinal cord.Design: Retrospective study.Methods: Subjects were 28 patients with OLF at T10-11 (15 patients), T11-12 (11), T12-L1 (2). The tip conus medullaris was assessed using computed tomographic myelography or magnetic resonance imaging. Neurologic evaluations performed for patellar tendon reflex (PTR), sensory disturbance, motor weakness.Results:...
Study Design. A retrospective study. Objective. This study investigated the pathophysiology of compressive cervical myelopathy (CCM) with prolonged central motor conduction time (CMCT) in upper limbs (ULs) rather than lower (LLs) and CMCT at thoracic level (TL). Summary Background Data. Earlier reports indicated usefulness to assess preoperative CCM severity. However, little information exists on patients CMCT-UL CMCT-LL CMCT-TL. Methods. Ninety-four (61 men, 33 women; age 28–87 years) who...
Granulocyte colony-stimulating factor (G-CSF) is generally used for neutropaenia. Previous experimental studies revealed that G-CSF promoted neurological recovery after spinal cord injury (SCI). Next, we moved to early phase of clinical trials. In a I/IIa trial, no adverse events were observed. conducted non-randomised, non-blinded, comparative which suggested the efficacy promoting recovery. Based on those results, are now performing III trial.The objective this study evaluate acute SCI....
The most common cause of lumbar spinal canal stenosis is age-related degenerative changes. ligamentum flavum said to become thicker and stiffer with age, based on several histological cadaver studies. However, there are no studies determining the changes mechanical properties in live patients. We examined patients evaluated A total 44 undergoing decompression surgery due disease at our institute were included. was harvested from site as a part necessary procedure for decompression. tensile...
Case studies of patients with cervical spondylotic amyotrophy used compound muscle action potentials (CMAPs) deltoid and biceps brachii muscles central motor conduction time (CMCT).To discuss surgical outcome for proximal-type in the context results obtained CMAPs CMCT.There have been no reports that correlate or CMCT.A retrospective study was performed 24 who underwent treatment spine. Erb-point-stimulated were recorded biceps. The percent amplitude calculated comparison opposite side....
Single-center retrospective study.To reveal the characteristic changes in central motor conduction time (CMCT) produced by transcranial magnetic stimulation among responsible levels of cervical compressive myelopathy (CCM).CMCT is a useful and noninvasive measure for evaluating pathway. However, systematic correlation between CMCT findings level CCM has so far not been addressed large patient cohort.We measured 75 patients with who were determined intraoperative spinal cord evoked potentials...
A prospective multicenter observational study.To elucidate the efficacy of transcranial motor-evoked potentials (Tc(E)-MEPs) in degenerative cervical myelopathy (DCM) surgery by comparing spondylotic (CSM) to ossification posterior longitudinal ligament (OPLL) and investigate timing Tc(E)-MEPs alerts types interventions affecting surgical outcomes.Although CSM OPLL are most commonly encountered diseases DCM, benefits for DCM remain unclear comparisons these two have not yet been conducted.We...