A5053889199- Asymmetric Synthesis and Catalysis
- Spine and Intervertebral Disc Pathology
- Cardiovascular and exercise physiology
- Spinal Fractures and Fixation Techniques
- Non-Invasive Vital Sign Monitoring
- Advanced Neuroimaging Techniques and Applications
- Asymmetric Hydrogenation and Catalysis
- Advanced MRI Techniques and Applications
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Thermoregulation and physiological responses
- Medical Imaging and Analysis
- Orthopaedic implants and arthroplasty
- Acute Ischemic Stroke Management
- Musculoskeletal pain and rehabilitation
- Orthopedic Infections and Treatments
- Chemical Synthesis and Reactions
- Synthesis and Catalytic Reactions
- Mesoporous Materials and Catalysis
- Cerebrovascular and Carotid Artery Diseases
- Pharmacological Effects and Toxicity Studies
- HER2/EGFR in Cancer Research
- Myofascial pain diagnosis and treatment
- Chronic Lymphocytic Leukemia Research
- Catalysis for Biomass Conversion
Keio University
2018-2025
Keio University Hospital
2019-2025
Ono Clinic
2022-2024
Doshisha University
2024
Hyogo University
2024
Kyoto first Red Cross hospital
2017-2023
Nippon Veterinary and Life Science University
2023
Japanese Red Cross Society Kyoto Daini Hospital
2022
Red Cross Hospital
2020-2022
Kyoto Prefectural University of Medicine
2018-2022
A highly reactive and acidic chiral Brønsted acid catalyst, N-triflyl phosphoramide, was developed. Highly enantioselective Diels−Alder reaction of α,β-unsaturated ketone with silyloxydiene demonstrated using this catalyst.
Brønsted and Lewis face off: A new chiral N-triflyl phosphoramide is used for asymmetric 1,3-dipolar cycloaddition of diaryl nitrones to ethyl vinyl ether give the endo products in up 93 % ee (see scheme; Tf=trifluoromethanesulfonyl; Ad=adamantyl). The structure was confirmed by X-ray crystallographic analysis. Supporting information this article available on WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z705314_s.pdf or from author. Please note: publisher not responsible content...
Abstract Background Rats are a widely accepted preclinical model for evaluating intervertebral disc (IVD) degeneration and regeneration. IVD morphology is commonly assessed using histology, which forms the foundation quantifying state of degeneration. severity evaluated different grading systems that focus on distinct degenerative features. A standard system would facilitate more accurate comparison across laboratories robust comparisons models interventions. Aims This study aimed to develop...
Stathmin is an intracellular phosphoprotein that overexpressed in a number of human malignancies. Our previous study using proteomic profiling showed significant upregulation stathmin occurs oral squamous-cell carcinoma (OSCC)-derived cell lines. In the current study, to determine potential involvement OSCC, we evaluated state protein and mRNA expression OSCC-derived lines primary OSCCs. A increase was observed all examined compared normal keratinocytes. immunohistochemistry, 65% OSCCs were...
Heterochiral [7.7]-P-spirocyclic arylaminophosphonium barfates have been designed as a novel charged, cationic Brønsted acid catalyst, and their catalytic stereocontrolling abilities clearly demonstrated in the development of unprecedented, highly enantioselective conjugate addition arylamines to nitroolefins. This study uncovers new function chiral tetraaminophosphonium cations its potential synthetic utility, thereby providing avenue molecular design charged catalysts applications.
The lactate threshold (LT1), which is defined as the first rise in concentration during incremental exercise, has not been non-invasively and conveniently determined a clinical setting. We aimed to visualize changes sweat exercise using our wearable sensor investigate relationship between (LT1) ventilatory (VT1). Twenty-three healthy subjects 42 patients with cardiovascular diseases (CVDs) were enrolled. During dynamic values visualized real-time sharp continuous increase up volitional...
It is difficult to control the enantioselectivity in protonation of silyl enol ethers with simple chiral Brønsted acids, mainly due bond flexibility between proton and its counterion, orientational proton, fact that sources available are limited acidic compounds such as carboxylic acids. To overcome these difficulties, we have developed a Lewis acid-assisted acid (LBA) system. The coordination acids restricts orientation protons increases their acidity. Optically active binaphthol (BINOL)...
A highly enantioselective sulfa-Michael addition to aromatic and aliphatic nitroolefins is achieved under the synergistic catalysis of chiral, ionic Brønsted acid homo-1b·HBArF 2,6-lutidine. The potential utility this new method clearly demonstrated by its application syntheses a novel, optically active taurine derivative β-sultam.
A previous randomized phase 2 study of hepatocellular carcinoma revealed that the c-Met inhibitor tivantinib as second-line treatment significantly prolonged progression-free survival in a subpopulation whose tumor samples highly expressed (MET-high). Accordingly, this 3 was conducted to evaluate efficacy for Japanese patients with MET-high carcinoma. This randomized, double-blind, placebo-controlled at 60 centers Japan. Hepatocellular one prior sorafenib and those were eligible inclusion....
Brønsted- und Lewis-Säuren: Ein neues chirales N-Triflylphosphoramid katalysiert die asymmetrische 1,3-dipolare Cycloaddition von Diarylnitronen an Ethylvinylether, bei der endo-Produkte mit bis zu 93 % ee entstehen (siehe Schema; Tf=Trifluormethansulfonyl; Ad=Adamantyl). Die Struktur des chiralen Phosphoramids wurde röntgenkristallographisch bestätigt.
KW-2478 is a novel non-ansamycin Hsp90 inhibitor with modest single-agent activity in relapsed/refractory myeloma but which shows synergistic antimyeloma bortezomib (BTZ) preclinical studies. This study determined the safety, preliminary clinical activity, and pharmacokinetics of KW-2478, an inhibitor, combination BTZ patients multiple (MM).Phase I dose escalation recommended phase II (RP2D) plus BTZ, was then used during II.The maximum tolerated not reached RP2D 175 mg m-2 1.3 on days 1, 4,...
Prolonged computer work and smartphone use can cause stiffness of the neck shoulder muscles, including trapezius muscle. Hence, muscle hardness quantification is clinically beneficial. The present study aimed to examine reliability measurement using a portable meter ultrasound strain elastography. Overall, 20 healthy young men participated in this study. Prior measurement, participant’s subjective symptoms, particularly stiffness, were rated an 11-point verbal scale. Furthermore, right left...
The relationship between the onset of sweating (OS) and sweat lactate threshold (sLT) assessed using a novel sensor remains unclear. We aimed to investigate implications OS on sLT. Forty healthy men performed an incremental cycling test. monitored lactate, blood local rates determine sLT, LT (bLT), OS. defined participants with during warm-up just before test as early perspiration (EP) group others regular (RP) group. Pearson's correlation coefficient analysis revealed that was poorly...
Abstract Hypoxic training enhances endurance sports tolerance. However, individual responses vary due to physiological differences. This study investigated the relationship between genetic factors and exercise tolerance in hypoxic conditions. randomized crossover included 22 male university students (age 20.8±1.3 years, peak oxygen uptake 54.5±6.5 mL/min/kg). Incremental load tests were conducted assess symptomatic limit on separate days under normoxic conditions (oxygen concentration...
Cinacalcet hydrochloride (cinacalcet) is a positive allosteric modulator of the calcium-sensing receptor indicated for treatment secondary hyperparathyroidism in dialysis patients. In vitro study has demonstrated that cinacalcet potent inhibitor cytochrome P450 (CYP) 2D6 with K(i) value 0.087 micromol/L, which comparable to well-known CYP2D6 inhibitor, quinidine (0.064 micromol/L). A clinical was conducted assess inhibitory effect on substrates healthy volunteers. Each subject received 50 mg...
Efficient and selective: Two lipophilic catalysts were used for Baeyer–Villiger (BV) oxidations to give lactones in high yields (see scheme). Cascade reactions involving this BV oxidation selectively obtain either unsaturated carboxylic acids or hydroxylactones from β-silyl cyclohexanones.
KW-2478 is a novel, non-ansamycin, non-purine heat-shock protein 90 (Hsp90) inhibitor. In this phase I, multicentre study, was administered intravenously over 1 h at doses ranging from 14 to 176 mg m–2 once daily on days 1–5 of 14-day cycle in standard 3+3 design 27 patients (22 with multiple myeloma and 5 non-Hodgkin lymphoma). Patients enrolled had relapsed/refractory disease previously treated ⩾2 regimens. There were no dose-limiting toxicities, thus the maximum-tolerated dose not...
Pull-out force and insertion torque have not been generally used as intraoperative measures for the evaluation of pedicle screw stability because their invasiveness. On other hand, resonance frequency analysis is a non-invasive repeatable technique that has clinically in dentistry to evaluate implant e.g. by Osstell apparatus. In this study, characteristics quotient (ISQ) value obtained apparatus field spinal surgery were investigated. Biomechanical test materials simulating human bone...
To predict conventional test forces (peak torque and pull-out force) a new force (implant stability quotient [ISQ] value of spinal pedicle screw) from computed tomography (CT) parameters, including micro-architectural using high-resolution micro-CT clinical multislice CT (MSCT) in human cadaveric vertebrae. Micro-CT scans before/after screw insertion (n = 68) MSCT before 58) vertebrae were assessed for ISQ value. Three-dimensional volume position adjustment between pre-insertion...
Abstract Background Technological innovations have allowed the use of miniature apparatus that can easily control and program heat cold stimulations using Peltier elements. The wearable thermo-device has a potential to be applied conventional contrast bath therapy. This study aimed examine effects alternating stimulation (HC) on subjective objective improvement shoulder stiffness. Methods Twenty healthy young male individuals (20.3 ± 0.6 years) participated in this study. interventions were...
Background Skeletal muscles include fast and slow muscle fibers. The tibialis anterior (TA) is mainly composed of fibers, whereas the soleus (SOL) However, a noninvasive approach for appropriately investigating characteristics not available. Monitoring skeletal can help in evaluation effects strength training diseases on muscles. Purpose present study aimed to determine whether q-space imaging distinguish between TA SOL vivo mice. Methods In magnetic resonance right calves mice (n = 8) was...
Spinal compression fractures commonly occur at the thoracolumbar junction. We have previously constructed a 3-dimensional whole-spine model from medical images by using finite element method (FEM) and then used this to develop fracture model. However, these models lacked rib cage. No previous study has including cage analyze fractures. Therefore, in study, we added models. models, normal spine without cage, with fractures, FEM analysis. Then, simulated person falling on buttocks perform...