A5065205549- Pulmonary Hypertension Research and Treatments
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Cerebrovascular and genetic disorders
- Hydrogen's biological and therapeutic effects
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Moyamoya disease diagnosis and treatment
- Cardiac Arrhythmias and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Blood Coagulation and Thrombosis Mechanisms
- Atrial Fibrillation Management and Outcomes
- Genetics and Physical Performance
- Connective tissue disorders research
- Neurological diseases and metabolism
- Eosinophilic Disorders and Syndromes
- Nuclear Receptors and Signaling
- Cardiovascular Effects of Exercise
- Cardiac tumors and thrombi
- Alcoholism and Thiamine Deficiency
- Hemodynamic Monitoring and Therapy
- Vitamin K Research Studies
- Lipoproteins and Cardiovascular Health
- Cardiac electrophysiology and arrhythmias
- PI3K/AKT/mTOR signaling in cancer
- Diabetes, Cardiovascular Risks, and Lipoproteins
Keio University
2020-2025
Keio University Hospital
2021-2024
Yokohama Municipal Citizen's Hospital
2018
Tokyo Metropolitan Bokutoh Hospital
2000
The benefits of inhaling hydrogen gas (H2) have been widely reported but its pharmacokinetics not yet sufficiently analyzed. We developed a new experimental system in pigs to closely evaluate the process by which H2 is absorbed lungs, enters bloodstream, and distributed, metabolized, excreted. inserted secured catheters into carotid artery (CA), portal vein (PV), supra-hepatic inferior vena cava (IVC) allow repeated blood sampling performed bilateral thoracotomy collapse lungs. Then, using...
The ring finger protein 213 gene (RNF213) encodes a 590 kDa that is thought to be involved in angiogenesis. This was first recognized as vasculopathy-susceptibility locus through genome-wide association studies undertaken Japanese population, demonstrating heterozygotes for RNF213 p.Arg4810Lys (c.14429G>A, rs112735431) had greatly increased risk of moyamoya disease. susceptibility variant disease reproduced Korean and Chinese individuals and, later, Caucasians. Variants the have been linked...
Failure of the right ventricle plays a critical role in any type heart failure. However, mechanism remains unclear, and there is no specific therapy. Here, we show that predominantly expresses alternative complement pathway-related genes, including Cfd C3aR1. Complement 3 (C3)-knockout attenuates ventricular dysfunction fibrosis mouse model C3a produced from C3 by convertase complex, which includes essential component factor D (Cfd). Cfd-knockout mice also attenuation Moreover, plasma...
Abstract Hypoxic training enhances endurance sports tolerance. However, individual responses vary due to physiological differences. This study investigated the relationship between genetic factors and exercise tolerance in hypoxic conditions. randomized crossover included 22 male university students (age 20.8±1.3 years, peak oxygen uptake 54.5±6.5 mL/min/kg). Incremental load tests were conducted assess symptomatic limit on separate days under normoxic conditions (oxygen concentration...
Drinking hydrogen (H2)-rich water is a common way to consume H2. Although many studies have shown efficacy of drinking H2-rich in neuropsychiatric and endocrine metabolic disorders, their authenticity has been questioned because none examined the associated pharmacokinetics Therefore, we performed first study investigate H2 pigs given an glucose solution with aim extrapolate findings humans. We inserted blood collection catheters into jejunal portal veins, suprahepatic inferior vena cava,...
Background: The evidence regarding triple oral combination therapy for patients with pulmonary arterial hypertension (PAH) is scarce. This study was performed to investigate the effectiveness and safety of macitentan, riociguat, selexipag. Methods: Among consecutive PAH who were referred our hospital from 2009 2020, those underwent using selexipag retrospectively analyzed. Hemodynamic echocardiographic assessments Kaplan–Meier analyses all-cause death initiation prostacyclin infusion...
Background The cause of chronic thromboembolic pulmonary hypertension (CTEPH) remains largely unknown. Recently, clonal hematopoiesis (CH) has been reported to be associated with cardiovascular and diseases. Here, we investigated the prevalence clinical impact CH in patients CTEPH. Methods Results Whole‐exome sequencing deep‐panel were performed 214 Clinical data before after treatment compared between without CH. RNA serum analysis explore pathogenesis that contributes Among enrolled...
Background Recently, some studies reported the pulmonary artery hypertension (PAH)-associated genes. However, a majority of patients with familial or sporadic PAH lack variants in known pathogenic In this study, we investigated new causative gene associated PAH. Methods and Results Whole-exome sequencing 242 Japanese identified heterozygous substitution change involving c.226G>A (p.Gly76Ser) tumor necrotic factor receptor superfamily 13B (TNFRSF13B) 6 (2.5%) patients. TNFRSF13B controls...
Recent studies have illuminated the importance of tet-methylcytosine-dioxygenase-2 (TET2) in pulmonary arterial hypertension (PAH). We aimed to clarify frequency TET2 variants Japanese PAH patients. Among whole-exome sequencing 145 patients with idiopathic or heritable PAH, 3 (2.1%) had a germline heterozygous missense variant (c.3116C > T, p.Ser1039Leu). The allele is 0.15% gnomAD database, and 0.2% among 3554 general population. These needed combination therapy including continuous...
Abstract Background Eukaryotic translation initiation factor 2 alpha kinase 4 (EIF2AK4) has been reported to be the causative gene of pulmonary veno-occlusive disease (PVOD).[1] Although some patients with arterial hypertension (PAH) also carry EIF2AK4 variants, its importance remains unclear. Purpose The purpose this study was evaluate prevalence and significance variants in PAH. Methods whole exome sequencing were performed total 162 idiopathic or heritable clinical data including...
Genetic backgrounds of patients with pulmonary arterial hypertension (PAH) were not fully investigated. A variant c.14429G > (p.Arg4810Lys) in the ring finger protein 213 gene (RNF213) was recently identified as a risk allele for poor treatment response and clinical prognosis PAH. However, molecular mechanisms RNF213 p.Arg4810Lys development PAH are unknown. We investigated underlying RNF213-associated vasculopathy using an vivo mouse model. RNF213+/p.Arg4828Lys mice, harboring heterozygous...
Obesity hypoventilation syndrome (OHS) is caused by complex interactions between multiple pathological processes, including diminished respiratory drive and sleep-related breathing alterations, leading to structural functional impairment ultimately, pulmonary hypertension (PH). Because PH closely associated with OHS, thoroughly evaluating its etiology essential, individualized treatments must be considered. We describe two patients OHS exhibiting severe vascular resistance exceeding 5 Wood...
Definitive diagnosis of familial hypercholesterolemia (FH) is paramount for the risk management patients and their relatives. The present study aimed to investigate frequency gene variants contributing low-density lipoprotein cholesterol (LDL-C) metabolism clinical relevance in with early-onset coronary artery disease (EOCAD). Among 63 consecutive EOCAD (men <55 years or women <65 years) who underwent percutaneous intervention (PCI) from 2013 2019 at Keio University Hospital, 52 consented...
Qing-Dai, a Chinese herbal medicine, has shown anti-inflammatory actions in refractory inflammatory bowel disease. However, pulmonary arterial hypertension (PAH) is one of the most serious side effects, and long-term clinical course Qing-Dai-induced PAH remains unknown. We present two patients with PAH, whose hemodynamics normalized after discontinuation Qing-Dai administration vasodilators. Notably, relapsed following This study suggests that regular checkups are necessary for chronic PAH....
The effective therapy for pulmonary arterial hypertension (PAH) with inadequate clinical response is scarce except lung transplantation when prostacyclin infusion ineffective. purpose of this study to investigate the efficacy and safety selexipag in addition prostacyclin. Nine patients [median 38 (36-49) years age; 78% female] PAH whose was despite use analogs, were evaluated. Addition significantly improved hemodynamics no serious adverse events observed. Selexipag analogs can be an...
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a lethal arrhythmic disease that can cause sudden cardiac death in young patients, with variants the ryanodine receptor 2 (RyR2) as primary causative gene.1 Hence, an accurate diagnosis essential for appropriate management. However, its usually delayed because of misdiagnosis epilepsy.2–4