A5056210848- Musculoskeletal pain and rehabilitation
- Spine and Intervertebral Disc Pathology
- Medical Imaging and Analysis
- Pregnancy-related medical research
- Occupational Health and Performance
- Pain Mechanisms and Treatments
- Shoulder Injury and Treatment
- Acupuncture Treatment Research Studies
- Lysosomal Storage Disorders Research
- Ergonomics and Musculoskeletal Disorders
- Scoliosis diagnosis and treatment
- Cervical and Thoracic Myelopathy
- Healthcare and Venom Research
- Anesthesia and Pain Management
- Injury Epidemiology and Prevention
- Dental materials and restorations
- Adolescent and Pediatric Healthcare
- Orthopaedic implants and arthroplasty
- Hepatitis B Virus Studies
- Viral Infections and Outbreaks Research
- Osteoarthritis Treatment and Mechanisms
- Advanced Glycation End Products research
- Health Literacy and Information Accessibility
- Obesity and Health Practices
- Influenza Virus Research Studies
Icahn School of Medicine at Mount Sinai
2014-2024
National Yunlin University of Science and Technology
2024
Mount Sinai Health System
2021
AO Foundation
2021
University of Pennsylvania
2021
Tokai University
2021
University of Cagliari
2016-2017
Hong Kong Polytechnic University
1996-2013
Abstract Background Rats are a widely accepted preclinical model for evaluating intervertebral disc (IVD) degeneration and regeneration. IVD morphology is commonly assessed using histology, which forms the foundation quantifying state of degeneration. severity evaluated different grading systems that focus on distinct degenerative features. A standard system would facilitate more accurate comparison across laboratories robust comparisons models interventions. Aims This study aimed to develop...
Background Pentosan polysulfate (PPS) is an FDA-approved, oral medication with anti-inflammatory and pro-chondrogenic properties. We have previously shown that animal models of the mucopolysaccharidoses (MPS) exhibit significant inflammatory disease, contributing to cartilage degeneration. Enzyme replacement therapy (ERT) only partly reduced inflammation, anti-TNF-alpha antibody significantly enhanced clinical pathological outcomes. Here we describe use PPS for treatment MPS type VI rats....
Backpack weight of 10–15% has been recommended as an acceptable limit for schoolchildren. However, there is still no clear guideline regarding where the backpack centre gravity (CG) should be positioned. The changes spinal curvature and repositioning error when carrying a loaded at 15% body different CG locations (anterior or posterior T7, T12 L3) in schoolchildren were analysed. Both found to affected by anterior–posterior position level. A relatively smaller change was observed during...
ABSTRACT The development of an in vivo rodent discogenic pain model can provide insight into mechanisms for painful disc degeneration. Painful degeneration rodents be inferred by examining responses to external stimuli, observing pain‐related behaviors, and measuring functional performance. This study compared the sensitivity multiple assessment methods disruption identifying parameters sensitive rats. Disc was induced rats annular injury with saline injection. severity degeneration,...
Painful intervertebral disc (IVD) degeneration has tremendous societal costs and few effective therapies. Intradiscal tumor necrosis factor-alpha (TNFα) is commonly associated with low back pain, but the direct relationship remains unclear.Treatment strategies for pain require improved understanding of complex relationships between intradiscal pro-inflammatory cytokines, structural IVD degeneration. A rat in vivo lumbar puncture model was used to 1) determine role TNFα initiating painful...
A rat puncture injury intervertebral disc (IVD) degeneration model with structural, biomechanical, and histological analyses.To determine if males females have distinct responses in the IVD after injury.Low back pain (LBP) spinal impairments are more common women than men. However, sex differences response to been underexplored, particularly animal models where can be measured without gender confounds.Forty-eight male female Sprague Dawley rats underwent sham, single annular tumor necrosis...
Abstract Back pain is linked to intervertebral disc (IVD) degeneration, but clinical studies show the relationship complex. This study assessed whether males and females have distinct relationships between IVD degeneration using an in vivo rat model. Forty-eight male female Sprague–Dawley rats had lumbar puncture or sham surgery. Six weeks after surgery, IVDs were evaluated by radiologic height, histological grading, biomechanical testing. Pain was von Frey assay dorsal root ganglia (DRG)...
We previously demonstrated the benefits of daily, oral pentosan polysulfate (PPS) treatment in a rat model mucopolysaccharidosis (MPS) type VI. Herein we compare these effects to once weekly, subcutaneous (s.c.) injection. The bioavailability injected PPS is greater than oral, suggesting better delivery difficult tissues such as bone and cartilage. Injected also effectively treats osteoarthritis animals, has shown success patients.One-month-old MPS VI rats were given weekly s.c. injections...
Chronic painful intervertebral disc (IVD) degeneration (i.e., discogenic pain) is a major source of global disability needing improved knowledge on multiple-tissue interactions and how they progress in order improve treatment strategies. This study used an vivo rat annulus fibrosus (AF) injury-driven pain model to investigate the acute chronic changes IVD spinal inflammation, as well sensitization, remodeling dorsal root ganglion (DRG) cord (SC) horn. AF injury induced moderate with broad...
In Brief Study Design. vitro and in vivo rat tail model to assess effects of torsion on intervertebral disc biomechanics gene expression. Objective. Investigate promoting biosynthesis producing injury caudal discs. Summary Background Data. Torsion is an important loading mode the increased torsional range motion associated with clinical symptoms from disruption. Altered elastin content implicated degeneration, but its are unknown. Although compression have been studied, effect expression...
Intervertebral disc (IVD) degeneration with Modic-like changes is strongly associated pain. Lack of effective disease-modifying treatments for IVDs endplate (EP) defects means there a need an animal model to improve understanding how EP-driven IVD can lead spinal cord sensitization. This rat in vivo study determined whether EP injury results dorsal horn sensitization (substance P, SubP), microglia (Iba1) and astrocytes (GFAP), evaluated their relationship pain-related behaviors,...
Type 2 diabetes and obesity are associated with back pain in juveniles adults implicated intervertebral disc (IVD) degeneration. Hypercaloric Western diets both type diabetes. The objective of this study was to determine if result spinal pathology a sex-specific manner using vivo diabetic dietary mouse models. Leptin is an appetite-regulating hormone, its deficiency leads polyphagia, resulting also IVD degeneration, increased expression receptor identified degenerated IVDs. We used young,...
Abstract Background The rabbit lumbar spine is a commonly utilized model for studying intervertebral disc degeneration and the pre‐clinical evaluation of regenerative therapies. Histopathology foundation which alterations to morphology cellularity with degeneration, or following repair treatment are assessed. Despite this, no standardized histology grading scale has yet been established field any frequently animal models. Aims purpose this study was establish new scoring system assess...
Developing effective therapies for back pain associated with intervertebral disc (IVD) degeneration is a research priority since it major socioeconomic burden and current conservative surgical treatments have limited success. Polyphenols are naturally occurring compounds in plant-derived foods beverages, evidence suggests dietary supplementation select polyphenol preparations can modulate diverse neurological painful disorders. This study tested whether standardized...
In Brief Study Design. An in vivo rat-tail model was used to study the effects of static compression with different loading magnitudes and durations on intervertebral disc. Objective. To investigate disc over a period time. Summary Background Data. A degeneration is essential for studying therapeutic degenerated Static can induce degenerative-like changes However, consequences simulation resting have not been clearly documented, which may confounding experimental outcome. Methods....
An in vivo rat-tail model was adopted to study the structural changes of degenerated intervertebral disc after different traction protocols.To investigate effects with modes and magnitudes on simulated degeneration.Traction has been commonly used clinical practice for treating low back pain. Its degeneration have not fully investigated.Forty-seven mature rats were used. Continuous static compression 11 N applied rat caudal 8-9 2 weeks simulate degeneration. Tractions (static or intermittent)...