A5088124900- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Synthesis and Catalytic Reactions
- Asymmetric Synthesis and Catalysis
- Catalytic C–H Functionalization Methods
- Oxidative Organic Chemistry Reactions
- Chemical Synthesis and Analysis
- Chemical Synthesis and Reactions
- Asymmetric Hydrogenation and Catalysis
- Radical Photochemical Reactions
- Sulfur-Based Synthesis Techniques
- Fluorine in Organic Chemistry
- Synthetic Organic Chemistry Methods
- Microbial Metabolic Engineering and Bioproduction
- Analytical Chemistry and Chromatography
- Axial and Atropisomeric Chirality Synthesis
- Crystallography and molecular interactions
- Chemical synthesis and alkaloids
- Enzyme Catalysis and Immobilization
- Phenothiazines and Benzothiazines Synthesis and Activities
- Synthesis and Biological Evaluation
- Viral Infections and Immunology Research
- Parasites and Host Interactions
- Microbial metabolism and enzyme function
- Animal Disease Management and Epidemiology
Beijing Normal University
2014-2025
Jining First People's Hospital
2024
Sichuan University
2024
Nankai University
2020-2022
State Key Laboratory of Medicinal Chemical Biology
2020
Tianjin International Joint Academy of Biomedicine
2020
Beijing Haidian Hospital
2014
Tsinghua University
2000-2012
Hebei Science and Technology Department
2010
University of Chicago
2008-2009
Brønsted and Lewis face off: A new chiral N-triflyl phosphoramide is used for asymmetric 1,3-dipolar cycloaddition of diaryl nitrones to ethyl vinyl ether give the endo products in up 93 % ee (see scheme; Tf=trifluoromethanesulfonyl; Ad=adamantyl). The structure was confirmed by X-ray crystallographic analysis. Supporting information this article available on WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z705314_s.pdf or from author. Please note: publisher not responsible content...
Chiral 1,2-diols have been prepared from alpha-aminoxylated aldehydes or cyclohexanone and Grignard reagents with L-proline its tetrazole derivative as the catalyst. The presence of ate complex CeCl(3)2 LiCl is essential for high overall yields good selectivities (see scheme; DMSO = dimethyl sulfoxide, THF tetrahydrofuran, Tol tolyl).
African swine fever virus, a large and complex icosahedral DNA causes deadly infection in domestic pigs. In addition to Africa Europe, countries Asia, including China, Vietnam, Mongolia, were negatively affected by the hazards posed ASFV outbreaks 2018 2019, at which time more than 30 million pigs culled. Until now, there has been no vaccine for protection against or effective treatments cure ASF. Here, we solved high-resolution crystal structure of pS273R protease. The protease two-domain...
CuI-catalyzed regio- and stereoselective dehalogenative ring-opening trifluoromethylations of geminal dibromo- or dichlorocyclopropanes monobromocyclopropanes delivered stereodefined trisubstituted disubstituted ethylenes bearing a CH2CF3 group in good yields. Purple light-promoted reductive monodebromination gem-dibromocyclopropanes was also developed.
Brønsted- und Lewis-Säuren: Ein neues chirales N-Triflylphosphoramid katalysiert die asymmetrische 1,3-dipolare Cycloaddition von Diarylnitronen an Ethylvinylether, bei der endo-Produkte mit bis zu 93 % ee entstehen (siehe Schema; Tf=Trifluormethansulfonyl; Ad=Adamantyl). Die Struktur des chiralen Phosphoramids wurde röntgenkristallographisch bestätigt.
Various β-nitro ketones, including those bearing a β-tertiary carbon, were prepared from geminal bromonitroalkanes and trimethylsilyl enol ethers of broad range ketones by visible light photoredox catalysis, which then easily converted into β-amino 1,3-amino alcohols, α,β-unsaturated β-cyano γ-nitro ketones.
1,3-Dipolar cycloadditions of triisopropylsilyl nitronates and 2-alkylacroleins produced isoxazolines bearing a chiral quaternary center in high yields enantioselectivities with the aid oxazaborolidine catalyst. One isoxazoline product was converted to (R)-(+)-Tanikolide 9 steps total yield 43%.
Highly enantioselective aziridination of chalcones catalyzed by a novel backbone 1,8-bisoxazolidinylanthracene (AnBOX) and CuOTf with up to >99% ee the opposite enantioselectivity compared ligands Evans are described.
Dicarboxylic acids (DCAs) can be obtained by oxidizing alkanes Candida tropicalis. Through alpha-monocarboxylic (MCAs), alpha- and omega-oxidation yield or omega-DCAs, respectively. However, both MCAs DCAs may degraded to acetyl-CoA beta-oxidation, resulting in a limited DCA yield. Acetyl-CoA transported into the mitochondrion for TCA cycle carnitine acetyltransferase (CAT), which energy generation beta-oxidation are connected. In this paper, we present method reconstruct metabolic pathway...
A catalytic asymmetric Diels–Alder reaction of an aryl vinyl ketone with 1,3-dienylcarbamate has been developed.
1,3-Dipolar cycloadditions of 2-alkylacroleins or atropaldehyde with triisopropylsilyl nitronates bearing an α-aryl group produced 3-aryl-2-isoxazolines having a chiral quaternary center in up to 94% ee and 88% yield the aid Corey's oxazaborolidine catalyst. Specifically, TIPS nitronate α-(p-methoxyphenyl) gave mainly 2-isoxazolines all-carbon center.
Cu(OTf)2 and chiral BOX ligand-catalyzed 1,3-dipolar cycloadditions of triisopropylsilyl nitronates with α,β-unsaturated carboximides produced isoxazolines in high yields, enantioselectivities, complete diastereoselectivities. These isoxazoline products were further converted into structurally diversified derivatives, which demonstrated the utility new method constructing isoxazolines. The transition-state structure cycloaddition was proposed light relative absolute configurations products.
Alkyl- and arylpyridines 2,2′-bipyridines are conventionally prepared by Minisci reactions of pyridines transition metal-catalyzed coupling halopyridines. Herein, purple light-promoted radical 2- or 4-bromopyridines with Grignard reagents in Et2O a mixture tetrahydrofuran regular glassware without the need for metal catalyst were disclosed first time. Methyl, primary secondary alkyl, cycloalkyl, aryl, heteroaryl, pyridyl, alkynyl compatible protocol. As result, alkyl- easily prepared. Single...
Abstract Chirale 1,2‐Diole wurden ausgehend von α ‐aminoxylierten Aldehyden oder Cyclohexanon und Grignard‐Reagentien mit L ‐Prolin dem gezeigten Tetrazolderivat als Katalysator erhalten. Die Gegenwart eines at‐Komplexes CeCl 3 ⋅2 LiCl ist entscheidend für hohe Ausbeuten Selektivitäten (siehe Schema; DMSO=Dimethylsulfoxid, THF=Tetrahydrofuran, Tol=Tolyl). magnified image
1-Aryl-α,β-unsaturated ketones were directly aziridinated, N-unsubstituted, in a one-pot reaction with satisfactory yields by N,N′-diamino-1,4-diazoniabicyclo[2.2.2]octane dinitrate, nitrogen–nitrogen ylide precursor, the presence of sodium hydride.
3-Oxazolin-5-ones are precursors of nitrile ylides and represent valuable 1,3-dipoles for constructing cyclic imines or pyrrole compounds. Harnessing the power photocatalysis, we accomplished a straightforward synthesis 3-oxazolin-5-ones from redox-active esters secondary nitro Visible light-induced nondecarboxylative coupling ester, aldol condensation, subsequent visible N-oxide deoxygenation were within 2 h. The reaction mechanism was supported by experimental data DFT calculations.
A mild and efficient coupling method concerning the reactions of gem-bromonitroalkanes with α,α-diaryl allyl alcohol trimethylsilyl ethers was reported. cascade consisting visible-light-induced generation an α-nitroalkyl radical a subsequent neophyl-type rearrangement key to realize reactions. Structurally diverse α-aryl-γ-nitro ketones, especially those bearing nitrocyclobutyl structure, were prepared in moderate high yields, which could be converted into spirocyclic nitrones imines.
Dearomative 1,3-dipolar cycloadditions of 1-Boc-pyrroles with in situ generated silver α-bromo alkylidenenitronates delivered a series 3 ,6 -dihydro-4-Boc-pyrrolo[2,3- d ]isoxazole-2-oxides (17–91% yields) under very mild conditions.