A5089163826- Spine and Intervertebral Disc Pathology
- Cervical and Thoracic Myelopathy
- Spinal Fractures and Fixation Techniques
- Spinal Cord Injury Research
- Neurogenesis and neuroplasticity mechanisms
- Nerve injury and regeneration
- Musculoskeletal pain and rehabilitation
- Knee injuries and reconstruction techniques
- Mesenchymal stem cell research
- Intraoperative Neuromonitoring and Anesthetic Effects
- Nerve Injury and Rehabilitation
- Total Knee Arthroplasty Outcomes
- Scoliosis diagnosis and treatment
- Spinal Hematomas and Complications
- Transcranial Magnetic Stimulation Studies
- Cardiac Imaging and Diagnostics
- Spinal Dysraphism and Malformations
- Orthopedic Surgery and Rehabilitation
- Medical Imaging and Analysis
- Tissue Engineering and Regenerative Medicine
- Cardiac Structural Anomalies and Repair
- EEG and Brain-Computer Interfaces
- Tendon Structure and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Orthopaedic implants and arthroplasty
Hiroshima General Hospital
2005-2024
Hiroshima University
2009-2018
Tokyo Medical University
2017
Hiroshima City Asa Citizens Hospital
2017
Yamaguchi University
2006-2015
Tokyo Women's Medical University Adachi Medical Center
2012-2013
Saitama Medical University
2013
Ministry of Education, Culture, Sports, Science and Technology
2006-2012
Saga University
1995-2010
In-Q-Tel
2006
Coronary revascularization guided by fractional flow reserve (FFR) is associated with better patient outcomes after the procedure than angiography alone. It unknown whether instantaneous wave-free ratio (iFR), an alternative measure that does not require administration of adenosine, will offer benefits similar to those FFR.
Study Design. A biomechanical and imaging study of human cadaveric spinal motion segments. Objective. To investigate the effect both disc degeneration facet joint osteoarthritis on lumbar segmental motion. Summary Background Data. Spinal includes osteoarthritic changes as well degeneration. Disc has been reported to be associated with The association characteristics combined influence not yet investigated. Methods. total 110 segments (52 female, 58 male) from 44 spines were studied (mean age...
An anatomic study of the cervical intervertebral foramina, nerve roots, and intradural rootlets performed using a surgical microscope.To investigate anatomy root compression, to obtain findings related foraminotomy for treatment radiculopathy.Cervical is procedure frequently management radiculopathy. However, studies have not been fully elucidated.In this study, 18 cadavers were obtained spine. All soft tissues dissected from Thereafter, laminectomy facetectomy on C4 through T1 microscope....
In Brief Study Design. Experimental study of spinal cord injury using an organotypic slice culture. Objective. To clarify the mechanism corticospinal axon regeneration following transplantation neural progenitor cells (NPCs) in injured cord. Summary Background Data. Several mechanisms underlying central nervous system after NPCs have been proposed; however, precise has not clarified. Previously, we demonstrated that transplanted secreted humoral factors turn promoted growth unique coculture...
A pathologic study of the ligamentum flavum in degenerative lumbar disease.To elucidate clinical significance each finding flavum.In many reports, researchers observed removed partially during surgery and did not evaluate whole image flavum. In addition, there are only a few reports that examined possible association between various histologic findings findings. And, thus, unclear points indicated by finding.The participants were 50 patients with diseases who underwent surgical decompression...
In Brief Study Design. Intraoperative neurophysiologic monitoring with transcranial electric motor-evoked potentials was performed on patients who underwent cervical laminoplasty at a university hospital in prospective study. Objective. To evaluate the usefulness of intraoperative spinal cord for prediction occurrence segmental motor paralysis after laminoplasty. Summary Background Data. Segmental occasionally occurs among undergo expansive myelopathy, and it has been attributed to nerve...
A biomechanical study on the cadaveric human lumbar spine.We focused a comparison of changes wrought motion segments after minimally invasive decompression and conventional medial facetectomy.Minimally posterior using microscope or an endoscope is becoming popular for elderly patients with spinal canal stenosis. An advantage technique that cauda equina nerve roots are in clear view facet joints, paravertebral muscles, spinous process well preserved.Eight were used this study. Each specimen...
Systemic circulation management has not been established for patients with poor grade aneurysmal subarachnoid hemorrhage (SAH) or delayed cerebral ischemia (DCI) after SAH. The aims of the study were to examine hemodynamic variables in these and establish treatment strategies.A multicenter prospective cohort from days 1 14 was performed using a transpulmonary thermodilution system (PiCCO Plus). Parameters analyzed by Mann-Whitney test. Multivariate analysis identify parameters involved onset...
Abstract Attenuation of the secondary injury spinal cord (SCI) can suppress spread tissue damage, possibly resulting in sparing that improve functional prognoses. Granulocyte colony-stimulating factor (G-CSF) is a haematological cytokine commonly used to treat neutropenia. Previous reports have shown G-CSF promotes recovery rodent models SCI. Based on preclinical results, we conducted early phase clinical trials, showing safety/feasibility and suggestive efficacy. These lines evidence...
To determine the epitopic structure for an anti-GalNAca-Ser(Thr) (anti-Tn) monoclonal antibody, MLS 128, asialo-ovine submaxillary mucin was digested with various proteases, and digests were fractionated by immunoaffinity column chromatography high performance liquid chromatography.From tryptic digest, a glycopeptide, GP-I, five other glycopeptides, GP-1-5, obtained as bound unbound fractions, respectively, of column.By solid phase radioimmunoassaying, it found that GP-I strongly...
In Brief Study Design. Experimental animal study of treatment spinal cord injury (SCI). Objective. To investigate the therapeutic effects administering microRNA-210 (miR-210) to promote angiogenesis in a mouse SCI model. Summary Background Data. Despite many previous studies regarding SCI, there is no established clinical practice. miRNAs have attracted immense attention because their crucial role human disease, and they been proposed as potential new targets for SCI. Methods. At specific...
BackgroundIn 2007, the Japanese orthopaedic association back pain evaluation questionnaire (JOABPEQ) wasestablished to overcome limitations of original JOA scoring system developed in 1986. Although this new selfadministered is a more accurate outcome measure for evaluating patients with low pain, physicians were unable as certain exact status patientat single time point because lack reference values.This study aimed establish values JOABPEQ different age and gender groups using data...
We established a new magnetic targeting system in which bone marrow stromal cells migrate through the cerebrospinal fluid to desired site spinal cord rats. Subarachnoid injection has been reported as minimally invasive method of transplantation for injury. It may be, however, less effective than direct into terms cell delivery. After implantation magnet, subarachnoid labeled with beads was performed. Greater numbers aggregated on surface owing force. This be useful tool treatment
Prospective cohort study.To compare the novel treatment procedure with nonoperative for low back pain (LBP) in elderly patients degenerative lumbar scoliosis (DLS).Treatment of LBP associated DLS is controversial. We developed a procedure, termed percutaneous intervertebral-vacuum polymethylmethacrylate injection (PIPI).We included de novo aged ≥65 years who had visual analogue scale (VAS) score >50 ≥6 months intervertebral vacuum and vertebral bone marrow edema (BME) defined on...
Lnk is an intracellular adaptor protein reported as a negative regulator of proliferation in c-Kit positive, Sca-1 lineage marker-negative (KSL) bone marrow cells. The KSL fraction mouse believed to represent population hematopoietic and endothelial progenitor cells (EPCs). We report here that, vitro, Lnk(-/-) form more EPC colonies than Lnk(+/+) show higher expression levels marker genes, including CD105, CD144, Tie-1, Tie2, their wild-type counterparts. In vivo, the administration spinal...
Study Design Expansive cervical laminoplasties with interconnected porous calcium hydroxyapatite ceramic (IP-CHA) spacers were performed in myelopathy patients. Objectives To evaluate the usefulness and osteoconductive capability of IP-CHA expansive laminoplasty. Summary Background Data laminoplasty for is designed to preserve posterior structures, so as prevent postoperative development instability kyphosis. The technique requires successful reconstruction laminae vertebral arches, sinking...