A5051493876- Spine and Intervertebral Disc Pathology
- Scoliosis diagnosis and treatment
- Spinal Fractures and Fixation Techniques
- Musculoskeletal pain and rehabilitation
- Orthopaedic implants and arthroplasty
- Osteoarthritis Treatment and Mechanisms
- Hip disorders and treatments
- Pain Mechanisms and Treatments
- Shoulder Injury and Treatment
- Total Knee Arthroplasty Outcomes
- Orthopedic Infections and Treatments
- Inflammatory mediators and NSAID effects
- Bone Tissue Engineering Materials
- Shoulder and Clavicle Injuries
- Orthopedic Surgery and Rehabilitation
- Nerve injury and regeneration
- Nerve Injury and Rehabilitation
- Tendon Structure and Treatment
- Anesthesia and Pain Management
- Hip and Femur Fractures
- Neuropeptides and Animal Physiology
- Bone and Joint Diseases
- Periodontal Regeneration and Treatments
- Cervical and Thoracic Myelopathy
- Musculoskeletal synovial abnormalities and treatments
Kitasato University
2016-2025
Kitasato University Hospital
2013-2024
Funabashi Orthopaedic Hospital
2023
University of Florida
2023
Seirei Sakura Citizen Hospital
2023
University of Tsukuba
2023
Open Evidence
2022
Level (Czechia)
2022
Shonan University of Medical Sciences
2020-2022
Chiba University
2004-2021
Prospective study.To examine the efficacy of teriparatide or bisphosphonate treatment to reduce pedicle screw (PS) loosening after instrumented lumbar posterolateral fusion in postmenopausal women with osteoporosis.Failure fixation caused by PSs osteoporosis is a problem spinal surgery. Oral administration intermittent injection parathyroid hormone increases bone mass and reduces risk osteoporotic vertebral fractures. Although these treatments may be factor improving quality, clinical study...
In Brief Study Design. Prospective trial. Objective. To examine the clinical efficacy of teriparatide for bone union after instrumented lumbar posterolateral fusion using local grafting in women with postmenopausal osteoporosis. Summary Background Data. Intermittent parathyroid hormone (PTH) treatment increases mass and reduces risk osteoporotic vertebral fractures. Recombinant human PTH (1–34) has already been approved as a severe Preclinical data support spinal fusion. However, results...
Pain from osteoarthritis (OA) is generally classified as nociceptive (inflammatory). Animal models of knee OA have shown that sensory nerve fibers innervating the are significantly damaged with destruction subchondral bone junction, and induce neuropathic pain (NP). Our objective was to examine NP in knees patients using painDETECT (an questionnaire) evaluate relationship between NP, intensity, stage OA.Ninety-two were evaluated this study. scores Visual Analogue Scales (VAS), Western...
A prospective trial of preoperative MRI study in patients with "idiopathic" scoliosis.To investigate the prevalence neural axis malformations and clinical relevance evaluation idiopathic scoliosis undergoing surgical intervention.With development MRI, abnormalities such as syringomyelia or Chiari are increasingly being found scoliosis. The risk neurologic complications during correction without prior decompression surgery for has been documented; however, there have no studies identifying a...
<h3>BACKGROUND AND PURPOSE:</h3> DTI can provide valuable structural information that may become an innovative tool in evaluating lumbar foraminal nerve root entrapment. The purpose of this study was to visualize the roots and measure their FA healthy volunteers patients with stenosis by using tractography 3T MR imaging. <h3>MATERIALS METHODS:</h3> Eight 8 underwent In all subjects, performed echo-planar imaging at a b-value 800 s/mm<sup>2</sup> were visualized tractography. Mean values...
Prospective randomized trial.To examine the effect of tumor necrosis factor alpha (TNF-α) inhibitor, etanercept, on radicular pain by its epidural administration onto spinal nerves in patients with lumbar stenosis.TNF-α is thought to play a crucial role caused disc herniation and stenosis. Intravenous infusion infliximab for sciatica has been examined 2 studies; however, results were equivocal.Eighty low back leg investigated. We diagnosed physical examination, X-ray magnetic resonance...
The object of this study was to examine the efficacy preoperative teriparatide treatment for increasing insertional torque pedicle screws during fusion surgery in postmenopausal women with osteoporosis.Fusion thoracic and/or lumbar spine performed 29 osteoporosis aged 65-82 years (mean 72.2 years). patients were divided into 2 groups based on whether they treated (n = 13) or not 16) before surgery. In teriparatide-treated group, received therapy as either a daily (20 μg/day, n 7) weekly...
Repetitive tensile stresses from valgus torque can induce elbow injury in adolescent baseball players. Insufficient hip range of motion (ROM) change throwing mechanics, reducing the transfer energy lower to upper extremities. Thus, ROM limitations may force extremities bear burden a strong throw. Improper pitching mechanics caused by insufficient are thought increase on when throwing, increasing risk injury.To investigate relationship between pain and players.Cross-sectional study; Level...
Summary Nerve growth factor (NGF) functions to modulate osteoarthritis (OA)-associated pain. Although recent studies suggest that tumour necrosis (TNF)-α and interleukin (IL)-1β mediate NGF activity in human synovial fibroblasts, the regulation of expression macrophages remains unclear. Here, we examined role production (SYN) osteoarthritic knee joints by examining mRNA TNF-α IL-1β freshly isolated CD14-positive (macrophage-rich fraction) CD14-negative cells (fibroblast-rich tissue from OA...
Analysis of the estrogen receptor gene girls with idiopathic scoliosis.To determine whether polymorphisms correlate curve severity adolescent scoliosis.Studies suggest that scoliosis is a familial condition and progression related to genetically determined factors, such as skeletal sexual growth.A total 304 were followed until growth maturation. Height, arm span, menarcheal age, age at maturation recorded, was measured using Cobb's method. The gene, which contains polymorphic PvuII XbaI...
The motions of chest wall and diaphragm were measured in patients with scoliosis healthy individuals using dynamic breathing magnetic resonance imaging.To investigate the during deep idiopathic scoliosis.Despite central role respiratory maintaining ventilation, it is difficult to measure describe because limited methods available. kinematics respiration have not yet been clarified.Dynamic fast spoiled gradient-recalled echo sequences used for 18 9 individuals. evaluated a cineloop view...
Prospective cohort study.To examine the relationship between low back pain after discectomy for disc herniation and Modic type 1 change.Lumbar vertebral bone marrow change is divided into types. Some reports indicate that related to pain, but reliability of this assertion unclear. The current study examines changes in patients with lumbar without fusion surgery.Forty-five showing normal or signals their were selected (mean age 35 years). All suffered leg because herniation, underwent a...
In Brief Study Design. A retrospective observational study of healthy volunteers and patients with degenerative infectious endplate abnormalities in the lumbar spine. Objectives. Our purpose was to evaluate usefulness diffusion-weighted imaging (DWI) for differentiation using 1.5-T magnetic resonance (MRI). Summary Background Data. DWI can provide valuable structural information about tissues that may be useful clinical applications between abnormalities. Methods. Sixteen consecutive...
The authors report on the usefulness and problems of a new surgical procedure--posterior corrective fusion using double-trajectory technique (cortical bone trajectory combined with traditional technique) in patient degenerative lumbar scoliosis osteoporosis--with aim achieving maintaining complete correction. A 64-year-old woman severe osteoporosis required decompression posterior fusion. Teriparatide therapy had recently been initiated, but impairment that she was experiencing her...
In addition to genetic factors, environmental and lifestyle factors are thought play an important role in the onset of adolescent idiopathic scoliosis (AIS). This cross-sectional study was conducted explore related AIS.This included 2,759 Japanese female junior high school students who planned a secondary screening after initial moiré topography indicated possible scoliosis. The their mothers, or guardians, were asked fill out questionnaire consisting 38 questions about demographic...
Case series.To present the difficulty of diagnosing origin lower leg pain in patients with lumbar spinal stenosis and hip joint arthritis.Pain arising from a degenerated is sometimes localized to leg. Patients disease may also show radicular corresponding area. If both conditions only at leg, it difficult determine pain.We reviewed 420 who had diagnosed by myelography, computed tomography after or magnetic resonance imaging. Pain ipsilateral lateral aspect but slight low back around was...
Purpose: Osteoarthritic pain is largely considered to be inflammatory pain.Sensory nerve fibers innervating the knee have been shown significantly damaged in rat models of osteoarthritis (OA) which subchondral bone junction destroyed, and this induces neuropathic (NP).Pregabalin was developed as a killer for NP; however, there are no reports on pregabalin use OA patients.The purpose study investigate efficacy patients.Materials Methods: Eighty-nine patients were evaluated randomized...
To investigate the role of macrophages as a regulator and producer nerve growth factor (NGF) in synovial tissue (ST) osteoarthritis (OA) joints, gene expression profiles several inflammatory cytokines ST, including fibroblasts, OA mice (STR/Ort) were characterized. Specifically, real-time polymerase chain reaction analysis was used to evaluate tumor necrosis factor- (TNF-) α , interleukin- (IL-) 1 β IL-6, NGF CD11b+ CD11b– cells isolated from ST murine model. The effects TNF- IL-1 IL-6 on...
Abstract We developed a new scaffold material—oriented collagen tubes (OCT)—and evaluated the potential of OCTs combined with basic fibroblast growth factor (bFGF) to repair 15 mm sciatic nerve defect in rats. The treatment groups consisted OCT adsorbed bFGF (OCT/bFGF group), phosphate‐buffered saline (PBS) (OCT/PBS and no‐treatment group (Defect group). Functional evaluation regeneration was performed using CatWalk system, histological analyses sites were also performed. In rats treated...
Research suggests that vascular endothelial growth factor (VEGF) levels in the synovial fluid of knee osteoarthritis (KOA) patients are positively correlated with KOA severity. The relationship between VEGF and pain human is not fully understood, role pathway remains unclear. We harvested membrane (SM) from 102 radiographic evidence (unilateral Kellgren/Lawrence [K/L] grade 2–4) during total arthroplasty. Patients scored their on a 0 to 10 cm visual analog scale (VAS). SM strong/severe (VAS...
ABSTRACT Nerve growth factor (NGF) is increased in intervertebral discs (IVDs) after disc injury and anti‐NGF therapy improves low back pain humans. Furthermore, M1 M2 macrophage subtypes play a role degenerative IVD injury. We examined markers NGF cytokine expression IVD‐derived cells from control IVD‐injured mice for 28 days following Ngf messenger RNA (mRNA) was 1 day injured compared with mice, persisted up to days. Flow cytometric analysis demonstrated that the proportion of F4/80+...