Abstract Osteoarthritis (OA) is a highly prevalent and intricate degenerative joint disease affecting an estimated 500 million individuals worldwide. Collagen‐based hydrogels have sparked immense interest in cartilage tissue engineering, but substantial challenges persist developing biocompatible robust crosslinking strategies, as well improving their effectiveness against the multifaceted nature of OA. Herein, novel discovery wherein simple incorporation ferrous/ferric ions enables...

Interaction between chondrocytes and the cartilage extracellular matrix (ECM) is essential for maintaining cartilage's role as a low-friction load-bearing tissue. In this study, we examined influence of zone-specific ECM on human articular (HAC) in two-dimensional three-dimensional (3D) environments. Two culture systems were used. SYSTEM 1: HAC cultured cell-culture plates that had been precoated with following molecules 7 days: decorin, biglycan, tenascin C (superficial zone), collagen type...

The repair of cartilage damage caused by trauma, wear, or degenerative deformation remains a major challenge in modern medicine. Therefore, it is essential to develop mechanically compatible and bioactive scaffold for tissue regeneration. In this study, mussel-inspired, tough, adhesive polydopamine/gelatin-poly(acrylic acid) (PDA/Gel-PAA) composite hydrogel was developed achieved high compressive strength up 0.67 MPa toughness 420 J/m2 because the unique chemical-physical cross-linking...

One of the factors that contribute to development aortic aneurysms is hemodynamic factors. In this study, we analyzed changes in a stented saccular abdominal aneurysm model improve We discovered stenting reduced wall shear stress, mean flow velocity aneurysm, energy loss, and pressure loss coefficient, improved hemodynamics around aneurysm. Stenting expected become new treatment modality for aneurysms. (This translation J Jpn Coll Angiol 2022; 62: 111-119.).

Growth and differentiation factor 15 (GDF15) is a cytokine reported to cause anorexia weight loss in animal models. Neutralization of GDF15 was efficacious mitigating cachexia improving survival cachectic tumor Interestingly, elevated circulating patients with pulmonary arterial hypertension heart failure, but it unclear whether contributes these disease conditions. In this study, rats treated monocrotaline (MCT) manifested progressive decrease body weight, food intake, lean fat mass...

Abstract Osteoarthritis (OA), characterized by chronic inflammation and cartilage degeneration, significantly affects over 500 million people globally. Nanoparticles have emerged as promising treatments for OA; however, current strategies often employ a single type of nanoparticle targeting specific disease stages, limiting sustained therapeutic efficacy. In this study, novel collagen hydrogel is introduced, thiol crosslinked collagen‐cerium oxide‐poly(D,L‐lactic‐co‐glycolic acid)...

The biomechanical simulation of the human respiratory system is expected to be a useful tool for diagnosis and treatment diseases. Because deformation thorax significantly influences airflow in lungs, we focused on simulating by introducing contraction intercostal muscles diaphragm, which are main responsible during breathing. We constructed finite element model thorax, including rib cage, muscles, diaphragm. To reproduce muscle contractions, introduced Hill-type transversely isotropic...

Vertebral fractures commonly occur at the thoracolumbar junction. These can be treated with mild residual deformity in many cases, but are reportedly associated increased risk of secondary vertebral fractures. In present study, a three‑dimensional (3D) whole spine model was constructed using finite element method to explore mechanism development compression The 3D spine, from cervical pelvis, computed tomography (CT) images an adult male. Using normal and models T11, T12 or L1 vertebrae,...

The most common cause of lumbar spinal canal stenosis is age-related degenerative changes. ligamentum flavum said to become thicker and stiffer with age, based on several histological cadaver studies. However, there are no studies determining the changes mechanical properties in live patients. We examined patients evaluated A total 44 undergoing decompression surgery due disease at our institute were included. was harvested from site as a part necessary procedure for decompression. tensile...

Inflammatory myofibroblastic tumor (IMT), a rare sarcoma, is primarily treated via resection of the mass. However, there no standard treatment for recurrence or unresectable tumors. Almost 50% IMTs carry ALK gene rearrangement that can be using inhibitors, but therapeutic options -negative tumors are limited. This report describes woman aged 22 years with IMT. Next-generation sequencing revealed TFG-ROS1 fusion, and she had partial response to ROS1 inhibitor ceritinib. provides first...

Decompression procedures for cervical myelopathy of ossification the posterior longitudinal ligament (OPLL) are anterior decompression with fusion, laminoplasty, and fusion. Preoperative postoperative stress analyses were performed compression from hill-shaped OPLL using 3-dimensional finite element method (FEM) spinal cord models.Three FEM models vertebral arch, OPLL, used to develop preoperative which 10%, 20%, 30% was applied; a fusion model posteriorly shifted arch; an advanced kyphosis...

No reports have described experiments designed to determine the strength characteristics of spinal nerve roots and rami radiculares for purpose explaining complexity symptoms medullary cone lesions cauda equina syndrome. In this study, explain pathogenesis syndrome, monoaxial tensile tests were performed radiculares, analysis was conducted evaluate stress-strain relationship characteristics. Using same test device, root ramus isolated from cords pigs subjected stress relaxation at load...

Adult brachial plexus injuries frequently lead to significant and permanent physical disabilities. Investigating the mechanism of injury using biomechanical approaches may further knowledge with regard preventing injuries. However, there are no reports studies till date. Therefore, present study used a complex three‑dimensional finite element model (3D‑FEM) analyze assess validity model. A 3D‑FEM spinal column, dura mater, nerve root, plexus, rib bone cartilage, clavicle, scapula, humerus...

The effect of intercostal muscle contraction on generating rib motion has been investigated for a long time and is still controversial in physiology. This may be because the complicated structure cage, making direct prediction relationship between force movement impossible. Finite element analysis useful tool that good at solving complex structural mechanic problems. In this study, we individually activated groups from dorsal to ventral portions obtained five different motions classified...

There are several techniques for lumbar interbody fusion, and implant failure following fusion can be troublesome. This study aimed to compare the stress in posterior peri-screw vertebral bodies among lateral (LLIF), (PLIF), transforaminal (TLIF) select technique that is least likely cause failure. We created an intact L3–L5 model simulated LLIF, PLIF, TLIF at L4–L5 using finite element methods. All models lower portion of L5 were fixed imposed a preload 400 N moment 7.5 Nm on upper L3...

Computational fluid dynamics analysis of the growth process saccular abdominal aortic aneurysm was performed. A 3D model created based on CT images. Properties in terms wall shear stress, mean flow velocity, pressure, energy loss, and pressure loss coefficient were calculated using thermal software "ANSYS CFX." As expanded, velocity decreased increased. Wall stress increased when small, suggesting that is related to development aneurysm. (This secondary publication from J Jpn Coll Angiol...

Osteoarthritis (OA) is characterised by cartilage destruction; however, there are no specific drugs available for its treatment. Cartilage-derived stem/progenitor cells (CSPCs) multipotent that play an essential role in renewal and may provide critical insights into the medical needs OA However, alterations cell function fate of CSPCs during progression have seldom been analysed, especially at single-cell level. Additionally, it has reported can migrate to injury area, although mechanism...

In spinal cord injuries, external forces from various directions occur at velocities. Therefore, it is important to physically evaluate whether the susceptible damage and an increase in internal stress for forces. We hypothesized that has mechanical features vary under depending on direction velocity of injury. However, difficult perform experiment because very soft. There are no reports effects multiple this study, we used bovine white matter test analyze anisotropy dependence cord....