A5100446536- Autoimmune and Inflammatory Disorders Research
- Rheumatoid Arthritis Research and Therapies
- Diabetes Treatment and Management
- Diabetes Management and Research
- Systemic Lupus Erythematosus Research
- T-cell and B-cell Immunology
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Gout, Hyperuricemia, Uric Acid
- Retinal Diseases and Treatments
- Immunotherapy and Immune Responses
- Spondyloarthritis Studies and Treatments
- Ovarian function and disorders
- Vasculitis and related conditions
- Nutrition and Health in Aging
- Immune Cell Function and Interaction
- Inflammasome and immune disorders
- GDF15 and Related Biomarkers
- Cytokine Signaling Pathways and Interactions
- Cell Adhesion Molecules Research
- IL-33, ST2, and ILC Pathways
- Psoriasis: Treatment and Pathogenesis
- Lipid metabolism and disorders
- Ginkgo biloba and Cashew Applications
- Muscle Physiology and Disorders
Xijing Hospital
2021-2025
Novo Nordisk (United States)
2025
Pfizer (United States)
2020-2025
Air Force Medical University
2021-2025
Xuzhou Medical College
2006-2024
Xuzhou Central Hospital
2017-2024
Guiyang Medical University
2018-2024
Affiliated Hospital of Guizhou Medical University
2018-2024
First Affiliated Hospital of Zhengzhou University
2023
Chinese People's Liberation Army
2022
OBJECTIVE—To assess safety, efficacy, and tolerability of pramlintide dose escalation with proactive mealtime insulin reduction, followed by optimization, in patients type 1 diabetes. RESEARCH DESIGN AND METHODS—This 29-week, double-blind, placebo-controlled study randomized 296 to or placebo as an adjunct insulin. During initiation, was escalated from 15 60 μg/meal (15-μg increments) recommended reductions (30–50%) Insulin subsequently adjusted optimize glycemic control. End points included...
The anorectic and weight-suppressive effects of growth differentiation factor-15 (GDF15) are attracting considerable attention for treating obesity. Current experiments in rats investigate whether GDF15 induces an aversive visceral malaise-based state that mediates its acute effect and, through aversion conditioning, exerts longer-term anorexia. Visceral malaise, conditioned affective food responses (taste reactivity), gastric emptying (GE), intake, body weight evaluated after chronic...
This research investigates the role of inhibitor differentiation 2 (Id2) in synthesis pro-inflammatory cytokines, specifically interferon-γ (IFN-γ) and interleukin-17 (IL-17), by various subsets T cells, its pathogenic rheumatoid arthritis (RA). Flow cytometry was employed to assess T-cell activation Id2 expression 72 RA patients 23 healthy controls. In vitro, peripheral blood mononuclear cells were treated with either an or a co-stimulation inhibitor. An vivo collagen-induced (CIA) model...
To assess the efficacy and safety of pramlintide in patients with type 2 diabetes suboptimally controlled basal insulin.In a 16-week, double-blind, placebo-controlled study, 212 using insulin glargine or without oral antidiabetes agents (OAs) were randomized to addition (60 120 microg b.i.d./t.i.d.) placebo. Insulin was adjusted target fasting plasma glucose concentration 70-100 mg/dl. One coprimary end point change A1C at week 16. The other composite measure overall control comprising < =...
Evidence is increasing that oral administration of probiotics can attenuate asthmatic responses both in murine models and clinical trials. T-helper 17 (Th17) cells, a subset CD4+ T cells have been implicated as having an important role the development several allergic disorders, but relationship between Th17 has not well studied. BALB/c mice were given lysed Enterococcus faecalis FK-23 (LFK) orally for 28 days. After sensitization by subcutaneous injection ovalbumin (OVA) on Days 14 21 1%...
Objectives This study aimed to investigate the changes in quantity and function of T helper (Th)-like regulatory (Treg) cell subsets peripheral blood (PB) synovial fluid (SF) rheumatoid arthritis (RA) patients understand their relationship with disease activity. Methods A total 86 RA 76 gender age-matched healthy controls (HC) were enrolled this study. Th-like Treg frequency determined using flow cytometry. The inhibitory cells was detected an vitro co-culture suppression assay. Results...
To assess the effect of adjunctive pramlintide treatment on satisfaction in patients with type 1 diabetes treated intensive insulin regimens.Intensively (multiple daily injection [MDI] or continuous subcutaneous infusion [CSII] pump therapy) completed a study-specific questionnaire following 29 weeks either placebo (n = 136) 130) double-blind, noninferiority dose titration trial. End points included patient reported outcomes, their relationship to regimen, A1C, weight, and...
We conducted this study to investigate the effects of combination therapy human chorionic gonadotropin (hCG) plus immunoglobulin (IG) on levels T helper 17 (Th17) cells and Foxp3+ regulatory (Treg) in patients with unexplained recurrent spontaneous abortion (URSA). Twenty pregnant women URSA underwent hCG IG. Flow cytometry was performed measure proportions Th17 Treg before after treatment. RT-PCR ELISA were applied detect concentrations interleukin (IL)-17, IL-6, IL-10, transforming growth...
BACKGROUND:To examine changes of mRNA and protein expressions MMP-2, Bcl-2, BAX in atrial fibrillation (AF) patients, investigate the correlations among these 3 biomarkers. MATERIAL AND METHODS:Rheumatic heart disease patients (n=158) undergoing cardiac surgical procedures for mitral valve repair or replacement were included as AF group (n=123), containing paroxysmal (n=42), persistent (n=36), permanent (n=45). Rheumatic with sinus rhythm (SR) (n=35) enrolled SR (control group)....
Abstract Aim Rheumatoid arthritis (RA) is a prevalent autoimmune disease characterized by immune dysegulation, including an imbalance due to abnormal activation of non‐classical Th1 cells (CD161 + Th1). This study investigated the effects CCR5 on and proliferation CD161 their pathogenicity in patients with RA. Methods The was conducted 53 RA 32 age‐ sex‐matched healthy controls (HC). cell phenotype assessed flow cytometry cytokine levels supernatant were detected ELISA. Results We...
Adiponectin (APN) belongs to adipokines. Previous studies showed contradictory results that have both proinflammatory and anti-inflammatory effects in rheumatoid arthritis (RA). We set out detect the levels of APN correlations between clinical manifestations RA patients. Sera 60 newly diagnosed patients with 29 age- gender-matched healthy subjects were collected. Clinical parameters, including C-reactive protein (CRP), erythrocyte sedimentation rate, factor (RF), antibodies cyclic...
Interleukin (IL)-34 is a new pro-inflammatory cytokine with elevated expression in rheumatoid arthritis (RA) patients. Our previous study showed that the frequency of T helper 17 (Th17) cells was also RA aimed to determine effects IL-34 on proliferation, transcription factor and secretion different subgroups CD4 + [Th1, Th2, Th17 regulatory (Treg) cells] Peripheral blood mononuclear (PBMCs) were isolated from peripheral 10 patients stimulated concentrations recombinant human (rh) (0, 25, 50...
Abstract Background Radiofrequency catheter ablation (RFCA) is an effective method for controlling the heart rate of paroxysmal atrial fibrillation (PAF). However, recurrence trouble under RFCA. To gain a deeper understanding risk factors in patients, we created nomogram model to provide clinicians with treatment recommendations. Methods A total two hundred thirty‐three patients PAF treated RFCA at Guizhou Medical University Hospital between January 2021 and December 2022 were consecutively...
Bioelectrical impedance analysis (BIA) is simple, noninvasive, inexpensive and frequently used for estimating fat free mass (FFM). The aims of this study were to evaluate the applicability different BIA equations on FFM in Chinese subjects, compare difference hemodialysis peritoneal dialysis patients with healthy controls respectively.Dialysis adults enrolled study, subjects matched by age, gender, minimum sample size each group was calculated using PASS. estimated Kyle, Sun SS Segal,...
To measure the serum levels of anticarbamylated protein (CarP) antibodies in patients with rheumatoid arthritis (RA) China and to evaluate association anti-CarP clinical parameters disease activity. 260 Chinese RA, 40 osteoarthritis (OA), 88 spondyloarthritis (SpA) 77 healthy controls were included. The detected by ELISA. Blood tests detect anticyclic citrullinated peptide (CCP) antibody level, factor (RF) erythrocyte sedimentation rate, C reactive level Disease Activity Score 28 joints...
The present study aimed to determine the differential expression profiles of proteins in endometrial carcinoma and screen associated with occurrence development cancer (EC). In total, 15 samples human EC paracancerous tissues were selected for proteomic analysis using a label‑free quantification method based on liquid chromatography‑tandem mass spectrometry. analysed bioinformatics verified reverse transcription‑quantitative PCR (RT‑qPCR) western blotting. Finally, 75 30 normal tissue...
Abstract Objectives To measure the levels of serum interleukin (IL)‐34 in patients with primary Sjögren's syndrome (pSS) and evaluate cytokine's clinical association disease. Methods Serum samples were obtained from 66 pSS 32 healthy controls (HCs) measured by enzyme‐linked immunosorbent assay for IL‐34 levels. The parameters, including autoantibodies, immunoglobulins (Igs), complements (Cs), inflammatory indicators, involvement blood system, lung arthritis, collected simultaneously....