A5019721689- Systemic Lupus Erythematosus Research
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Cytokine Signaling Pathways and Interactions
- Cytomegalovirus and herpesvirus research
- Vasculitis and related conditions
- Gout, Hyperuricemia, Uric Acid
- COVID-19 and Mental Health
- MicroRNA in disease regulation
- RNA modifications and cancer
- Liver Disease Diagnosis and Treatment
- Vitamin D Research Studies
- Liver Diseases and Immunity
- Pulmonary Hypertension Research and Treatments
- Diabetes and associated disorders
- Salivary Gland Disorders and Functions
- Inflammatory Myopathies and Dermatomyositis
- COVID-19 epidemiological studies
- Erythrocyte Function and Pathophysiology
- Congenital Ear and Nasal Anomalies
- Atherosclerosis and Cardiovascular Diseases
- RNA regulation and disease
- IgG4-Related and Inflammatory Diseases
- Inflammasome and immune disorders
Air Force Medical University
2016-2025
Xijing Hospital
2018-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Southern Medical University
2024
Ningbo University
2024
Lanzhou Institute of Chemical Physics
2024
First Affiliated Hospital of Zhengzhou University
2015-2024
Nanfang Hospital
2024
Qingdao University of Science and Technology
2023-2024
Chinese Academy of Sciences
2002-2024
Convolutional neural networks (CNNs) have made enormous progress in medical image segmentation. The learning of CNNs is dependent on a large amount training data with fine annotations. workload labeling can be significantly relieved via collecting imperfect annotations which only match the underlying ground truths coarsely. However, label noises are systematically introduced by annotation protocols, severely hinders CNN-based segmentation models. Hence, we devise novel collaborative...
Background Systemic lupus erythematosus (SLE) is an autoimmune disease that can affect multiple systems. Pulmonary arterial hypertension (PAH) has a close linkage with SLE. However, the inter-relational mechanisms between them are still unclear. This article aimed to explore shared gene signatures and potential molecular in SLE PAH. Methods The microarray data of PAH Gene Expression Omnibus (GEO) database were downloaded. Weighted Co-Expression Network Analysis (WGCNA) was used identify...
<h3>Importance</h3> Lupus nephritis (LN) is typically treated with intravenous cyclophosphamide (IVCY), which associated serious adverse effects. Tacrolimus may be an alternative for initial treatment of LN; however, large-scale, randomized clinical studies tacrolimus are lacking. <h3>Objective</h3> To assess efficacy and safety vs IVCY as therapy LN in China. <h3>Design, Setting, Participants</h3> This (1:1), open-label, parallel-controlled, phase 3, noninferiority trial recruited patients...
Abstract Background The current COVID-19 pandemic is effectively constrained by intensified public health measures in China, among which ubiquitous education plays a vital part. Objective This survey aims to understand the status quo acquisition of ongoing campaign university students. Methods We designed this cross-sectional investigated knowledge, attitude and practice (KAP) associated with students during their household isolation at peak pandemic. 872 undergraduates were recruited from...
Abstract Background: The COVID-19 pandemic has become a great threat to public health, which greatly impacted the study and life of undergraduate students in China. Objective: This aims perform survey their knowledge, attitude practice (KAP) associated with COVID-19. Methods: A cross-sectional was designed gather information regarding related KAP among undergraduates during home isolation outbreak. Subjects were recruited from 10 universities Shaanxi Province, Enrollees voluntarily submitted...
This study was designed to evaluate the distribution of Tregs/Th17/Th1 cells in type 2 diabetic patients with foot disease before and after human umbilical cord blood mesenchymal stem cell (hUCB-MSCs) transplantation. Fifteen under insulin therapy received hUCB-MSC The hUCB-MSCs were directly injected into quadriceps thigh muscles (cell quantity at 2x106 per point). Physical attributes, cytokines, glucose dosage evaluated treatment 1, 2, 4, 8, 12 weeks thereafter. ratios Treg/Th17, Treg/Th1,...
Saccharomyces cerevisiae is an important synthetic biology chassis for microbial production of valuable molecules. Promoter engineering has been frequently applied to generate more promoters with a variety defined characteristics in order achieve well-regulated genetic network high efficiency. Galactose-inducible (GAL) expression systems, composed GAL and multiple regulators, have widely used protein overexpression pathway construction S. cerevisiae. However, the function each element how...
Galactose-inducible (GAL) promoters have been widely used in metabolic engineering Saccharomyces cerevisiae for production of valuable products. Endogenous GAL and transcription factors often engineered to improve promoter activities. Heterologous activator (Gal4p-like transcriptional activators), although existing other yeasts or fungi, not well explored. In this study, we comprehensively characterized the activation effects Gal4p activators from different fungi on a variant promoters....
Objectives This study aimed to investigate the changes in quantity and function of T helper (Th)-like regulatory (Treg) cell subsets peripheral blood (PB) synovial fluid (SF) rheumatoid arthritis (RA) patients understand their relationship with disease activity. Methods A total 86 RA 76 gender age-matched healthy controls (HC) were enrolled this study. Th-like Treg frequency determined using flow cytometry. The inhibitory cells was detected an vitro co-culture suppression assay. Results...
Abstract Background Alterations in oral microbiota patients with systemic lupus erythematosus (SLE) is less evaluated. The aim of this study was to compare the characteristics microbiome SLE and healthy controls, construct an classifier based on microbiota. Methods We sequenced tongue-coating samples individuals treatment-naïve (n = 182) matched controls 280). characterized constructed a microbial derivation cohort validated results validation cohorts. Furthermore, posttreatment 73)...
Rh/sulfoxantphos-catalyzed hydroaminomethylation has been developed to afford corresponding linear amines with good yields (71–95%) high regioselectivities (l/ b up 132.4) and excellent catalytic activities (TON of Rh catalyst 23 760).
The aim of this study was to investigate whether vitamin D plays a protective role in podocyte injury induced by autoantibodies purified from the serum patients with lupus nephritis (LN) via reducing aberrant autophagy.Autophagic activities renal tissues LN were evaluated under transmission electronic microscope (TEM). Immunoglobulin G (IgG) induce human injury, and observed. Podocytes observed TEM, autophagic activity western blot analysis quantitative real-time polymerase chain reaction,...
Lupus nephritis (LN) is one of the most severe complications systemic lupus erythematosus (SLE). Circular RNAs (circRNAs) can act as competitive endogenous (ceRNAs) to regulate gene transcription, which involved in mechanism many diseases. However, role circRNA has been rarely reported. In this study, we aim investigate clinical value circRNAs and explore involvement pathogenesis LN.Renal tissues from three untreated LN patients normal controls (NCs) were used identify differently expressed...
Meplazumab, a humanized CD147 antibody, showed favorable safety and clinical benefits in phase 1 2/3 seamless studies. Further evaluation of its therapeutic efficacy patients with severe COVID-19 is needed. In this 3 add-on study, we randomized 1:1 ratio to receive 0.2 mg/kg meplazumab or placebo via intravenous injection, evaluated within 56 days. Between February 2023 November 2023, 108 were two groups, their baseline characteristics generally balanced. The primary endpoint, 28-day...
Symptomatic intracranial hemorrhage (ICH) may lead to permanent neurological disability of patients and has impeded the extensive clinical application deep brain stimulation (DBS). The present study was conducted discuss incidence, prevention, treatment symptomatic ICH after DBS surgery.From January 2009 December 2014, 396 underwent with a total 691 implanted leads. In all, 10 had ICH. We analyzed these cases' characteristics, including comorbid diagnoses coagulation profile. described onset...
On the basis of this molecular design, we obtained a TCF-SS-TPA compound. NPs showed NIR fluorescence and excellent 1 O 2 generation ability. Notably, photothermal conversion efficiency is as high 84.5%.
Lupus nephritis (LN) is a well-known complication of systemic lupus erythematosus and its leading cause morbidity mortality. Our study aimed to identify the molecular markers associated with pathophysiology treatment LN. The renal tissue gene expression profiles LN patients in GSE32591 dataset were downloaded as discovery cohort from Gene Expression Omnibus. Differentially expressed genes (DEGs) identified; weighted co-expression network analysis (WGCNA) was used modules DEGs; function...