A5002902707- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Advanced Polymer Synthesis and Characterization
- Synthesis and properties of polymers
- Erythropoietin and Anemia Treatment
- Polymer composites and self-healing
- Hydrogels: synthesis, properties, applications
- Muscle and Compartmental Disorders
- Central Venous Catheters and Hemodialysis
- Acute Kidney Injury Research
- biodegradable polymer synthesis and properties
- Electrospun Nanofibers in Biomedical Applications
- Parathyroid Disorders and Treatments
- Surface Modification and Superhydrophobicity
- Polymer crystallization and properties
- Silicone and Siloxane Chemistry
- Adsorption and biosorption for pollutant removal
- Polymer Nanocomposites and Properties
- Vasculitis and related conditions
- Advanced Sensor and Energy Harvesting Materials
- Renal and Vascular Pathologies
- Nanomaterials for catalytic reactions
- Membrane Separation Technologies
- Synthetic Organic Chemistry Methods
Beijing University of Chemical Technology
2015-2025
Ruijin Hospital
2016-2025
Shanghai Jiao Tong University
2015-2025
Chemical Synthesis Lab
2025
Materials Science & Engineering
2025
Huzhou University
2015-2020
Peking University
2018-2020
Peking University People's Hospital
2018-2020
Guangdong Provincial People's Hospital
2020
Renji Hospital
2020
Green and environment-friendly preparation are of the utmost relevance to development transparent antismudge coatings. To prepare a waterborne polyurethane (WPU) coating with property, it is challenging balance stability dispersion property coating. Herein, we bio-based WPU grafted minor proportion poly(dimethylsiloxane) (WPU-g-PDMS) using renewable castor oil, monocarbinol-terminated PDMS, hexamethylene diisocyanate trimer, 2,2-bis(hydroxymethyl)propionic acid as raw materials. Effects...
IgA nephropathy (IgAN) is a common cause of end-stage renal disease (ESRD) in Asia. In this study, based on large cohort Chinese patients with IgAN, we aim to identify independent predictive factors associated progression ESRD. We collected retrospective clinical data and outcomes 619 biopsy-diagnosed IgAN mean follow-up time 41.3 months. total, 67 individuals reached the study endpoint defined by occurrence ESRD necessitating replacement therapy. fully adjusted Cox proportional hazards...
<h3>Importance</h3> Lupus nephritis (LN) is typically treated with intravenous cyclophosphamide (IVCY), which associated serious adverse effects. Tacrolimus may be an alternative for initial treatment of LN; however, large-scale, randomized clinical studies tacrolimus are lacking. <h3>Objective</h3> To assess efficacy and safety vs IVCY as therapy LN in China. <h3>Design, Setting, Participants</h3> This (1:1), open-label, parallel-controlled, phase 3, noninferiority trial recruited patients...
In order to evaluate the clinical and pathological characteristics of diuretics associated acute kidney injury (AKI) its management.We performed a retrospective study including 131 cases that diagnosed as AKI from 1 January 1999 2010 in Ruijin Hospital affiliated Shanghai Jiao Tong University. Drug applications related clinical, laboratory histological data were collected.The male female ratio was 2:1. The proportion ages <20 years, 20-40 40-60 years ≥ 60 6.9%, 17.6%, 27.5% 48.1%...
A novel multiwalled carbon nanotube/polypropylene (CNT/PP) conductive fibrous membrane with fiber diameter of 1–3 μm was fabricated by melt electrospinning. To improve the dispersibility CNT and enhance spinnability PP fibers, CNTs were first mixed small amounts paraffin liquid (PL) then melt-blended for The morphology membranes orientation in fibers observed via scanning transmission electron microscopy (SEM TEM). effect PL on crystallization behavior studied differential calorimetry (DSC)...
Abstract The number of patients on hemodialysis (HD) is rapidly increasing in China. As an Asian country with a large HD patients, understanding the status Chinese has special significance. We reported here baseline data for China Dialysis Outcomes and Practice Pattern Study Phase 5 (DOPPS5). DOPPS international prospective, observational cohort study. Patients were restricted to initial sample who participated DOPPS5. summarized demographic clinical patients. Results weighted by facility...
Stimuli-responsive hybrid nanoparticles used for controllable catalysis have been attracting increasing attention. This study aims to prepare microgels with excellent temperature-sensitive colorimetric and catalytic properties through combining the surface plasmon resonance of gold (AuNPs) poly(N-isopropylacrylamide) (PNIPAM)-based microgels. Microgels hydroxy groups (MG-OH) were prepared by soap-free emulsion polymerization, using N-isopropylacrylamide as main monomer, hydroxyethyl...
Peritoneal dialysis (PD) shows promise for urgent-start in end-stage renal disease (ESRD), with automated PD (APD) having advantages. However, there is limited multicenter randomized controlled trial (RCT) evidence comparing APD temporary hemodialysis (HD) this indication China.
Advanced liquid-repelling materials that resist both water-based and oil-based contaminants have significant applications in many fields. Herein, a novel protocol for the fabrication of robust poly(high internal phase emulsion) (polyHIPE)-based slippery liquid-infused porous surface (SLIPS) system with combined self-repairing self-cleaning properties is developed. Specifically, polystyrene-based polyHIPE (PS-HIPE) membranes an interconnected structure were prepared from polymerization...
Most injectable hydrogels are prone to irreversible deformation or damage under sustained shear forces and exhibit low mechanical properties, which limit their practical applications in biological engineering. In this work, the first hydrogen-bonding reinforced thermoresponsive hydrogel system has been fabricated through an situ hydrazide–aldehyde cross-linking reaction between hydrazide-functionalized poly(N-isopropylacrylamide) (PNIPAM) dialdehyde dextrin. The strength stability of were by...
MicroRNAs (miRNAs) are small non-coding RNAs that participate in several cellular functions and tumour progression. A previous microarray study demonstrated miR-135b is downregulated prostate cancer (PCa) cells, but the role molecular mechanism of regulation metastasis remain to be elucidated. In present study, significant downregulation PCa tissues, compared with noncancerous was detected by reverse transcription-quantitative polymerase chain reaction. Furthermore, expression associated...
Abstract The curing process of a typically formulated spray polyurea elastomer (SPUA) system has been thoroughly investigated with the help combined analysis Fourier transform infrared spectroscopy, differential scanning calorimetry, and dynamic mechanical analysis. evolvement microstructure responses SPUA during have described in detail. experimental results indicated that fast property SPUA, which mainly based on reaction between primary amine groups isocyanate groups, led to formation...
ABSTRACT Injectable, de‐crosslinkable, and thermosensitive hydrogels are obtained by hydrazide‐functionalized poly( N ‐isopropylacrylamide) aldehyde‐functionalized dextrin through in situ crosslinked method. Natural based degradable starch nanoparticles (SNPs) used as fillers order to improve mechanical property of hydrogels. Internal morphology, dynamic modulus, thermosensitivity property, de‐crosslinking performance, drug release, vitro cytotoxicity investigated. Results show that SNPs...
Background and objectives At least 20 susceptibility loci of IgA nephropathy have been identified by genome-wide association studies to date. Whether these were associated with disease progression is unclear. Design, setting, participants, & measurements We enrolled 613 adult patients for a follow-up ≥12 months. All selected their tag single nucleotide polymorphisms (SNPs) genotyped. After strict quality control, 16 SNPs 517 eligible subsequent analysis. Progression was defined as ESKD...
<b><i>Background:</i></b> Gitelman syndrome (GS) is an autosomal recessive renal tubulopathy caused by inactivating mutations in the <i>SLC12A3</i> gene. Although hundreds of different across gene have been reported worldwide, data from mainland China are limited. We investigated clinical manifestations and genetic features Chinese patients with GS. <b><i>Methods:</i></b> Fifty-four unrelated clinically diagnosed GS were included....
Numerous α-galactosidase A (α-gal A) gene (GLA) mutations have been identified in Fabry disease (FD), but studies on genotype-phenotype correlation are limited. This study evaluated the features of GLA and relationship Chinese FD patients. Gene sequencing results, demographic information, clinical history, laboratory findings were collected from 73 Totally 47 identified, including 23 novel which might be pathogenic. For male patients, those with frameshift nonsense presented classical FD,...