A5100322617- Corneal surgery and disorders
- Ophthalmology and Visual Impairment Studies
- Glaucoma and retinal disorders
- Corneal Surgery and Treatments
- Intraocular Surgery and Lenses
- Ocular Surface and Contact Lens
- Retinal Diseases and Treatments
- Diabetes Treatment and Management
- Ocular Infections and Treatments
- Retinal Imaging and Analysis
- Growth Hormone and Insulin-like Growth Factors
- Cervical Cancer and HPV Research
- Ophthalmology and Eye Disorders
- Ocular and Laser Science Research
- Diabetes Management and Research
- Pregnancy and Medication Impact
- Pancreatic function and diabetes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Thyroid Cancer Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Mathematical and Theoretical Epidemiology and Ecology Models
- Optical measurement and interference techniques
- Retinal and Optic Conditions
- Liver Disease Diagnosis and Treatment
- Respiratory viral infections research
Tianjin Medical University
2016-2025
Nankai University
2014-2025
Tianjin Medical University Eye Hospital
2016-2025
Center for Drug Evaluation and Research
2018-2025
South China University of Technology
2023-2025
Guangdong Academy of Medical Sciences
2022-2025
Southern Medical University
2019-2025
Guangdong Provincial People's Hospital
2018-2025
Zhujiang Hospital
2023-2025
Hebei General Hospital
2022-2025
An organic solution-processable functionalized graphene (SPFGraphene) hybrid material with porphyrins is reported for the first time. FTIR, UV-vis absorption, and TEM studies confirm covalent functionalization of graphene. A superior optical limiting effect, better than benchmark C60 control sample, observed. Detailed facts importance to specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted by...
Despite the advent of new treatments, glucose control in type 2 diabetes population is unsatisfactory. AC2993 (synthetic exendin-4; exenatide), a novel glucose-dependent insulinotropic agent, exhibited notable antidiabetic potential two clinical studies patients with diabetes. In study A, 24 subjects received sc injections medication (0.1 μg/kg or placebo) twice daily meals for 5 d. Statistically significant reductions mean postprandial circulating concentrations glucose, insulin, and...
The emerging field of optical-triggered actuators based on polymeric nanocomposite continues to be the focus considerable research in recent years because their scientific and technological significance. In principle, dispersing nanofiller with unique characteristics polymer matrix can not only provide superb enhancement performance but also afford novel actuation schemes systems. Graphene, combining its unusual electrical, thermal, mechanical, optical properties, ability act as "energy...
Purpose To compare the biomechanical properties of cornea after small-incision lenticule extraction (lenticule group) with those femtosecond laser–assisted laser in situ keratomileusis (femtosecond LASIK group). Setting Tianjin Eye Hospital & Institute, Key Laboratory Ophthalmology and Visual Science, Medical University, Tianjin, China. Design Prospective comparative case series. Methods Corneal hysteresis (CH), corneal resistance factor (CRF), 37 other waveform parameters were...
Insulin-like growth factor-I receptor (IGF-IR) plays an important role in tumor cell and survival. On ligand stimulation, IGF-IR, a tyrosine kinase, phosphorylates residues on two major substrates, IRS-1 Shc, which subsequently signal through the Ras/mitogen-activated protein kinase phosphatidylinositol 3-kinase/AKT pathways. Here, we describe characterization of fully human anti-IGF-IR monoclonal antibody 19D12 that inhibits IGF binding autophosphorylation both IGF-IR/IGF-IR homodimers...
A facile solution approach was employed to synthesize α-FeOOH nanorods by using FeSO4·7H2O and CH3COONa without templates at low temperature (40 °C). The porous α-Fe2O3 were successfully obtained calcining the precursors 300 °C for 2 h. as-prepared products characterized thermogravimetry-differential thermal analysis, X-ray powder diffraction, transmission electron microscopy (TEM), high-resolution TEM, N2 adsorption−desorption analysis techniques. have a tiny crystal size (5 nm) pore...
OBJECTIVE—To assess safety, efficacy, and tolerability of pramlintide dose escalation with proactive mealtime insulin reduction, followed by optimization, in patients type 1 diabetes. RESEARCH DESIGN AND METHODS—This 29-week, double-blind, placebo-controlled study randomized 296 to or placebo as an adjunct insulin. During initiation, was escalated from 15 60 μg/meal (15-μg increments) recommended reductions (30–50%) Insulin subsequently adjusted optimize glycemic control. End points included...
Activation of TGFB (transforming growth factor β) promotes liver fibrosis by activating hepatic stellate cells (HSCs), but the mechanisms activation are not clear. We investigated role ECM1 (extracellular matrix protein 1), which interacts with extracellular and structural proteins, in mouse livers.We performed studies C57BL/6J mice (controls), ECM1-knockout (ECM1-KO) mice, hepatocyte-specific knockout EMC1 (ECM1Δhep). or soluble TGFBR2 (TGFB receptor 2) were expressed livers after injection...
Millions of individuals across the world suffer from corneal stromal diseases that impair vision. Fortunately, three-dimensional (3D) bioprinting technology which has revolutionized field regenerative tissue engineering makes it feasible to create personalized corneas. In this study, an artificial cornea with a high degree precision, smoothness, and programmable curvature was prepared by using digital light processing (DLP) 3D in one piece no support structure, construct then confirmed...
Hypertensive nephropathy is characterized by long-term damage to renal tissues chronic uncontrolled hypertension, and ultimately leads the development of fibrosis. The epithelial-mesenchymal transition (EMT) potentially contributes promotion fibrosis in kidney disease (CKD). In this study, we investigated potential roles canagliflozin (Cana) on EMT oxidative stress through its effects sirtuin 3 (SIRT3) expression. High-salt diet (HSD)-induced Dahl salt-sensitive rats hypertensive injury led...
Abstract Background The association between the triglyceride-glucose (TyG) index and likelihood of developing cardiovascular disease (CVD) in general elderly population United States aged 60 above is not well understood. objective our study was to examine relationship TyG CVD over years age States. Methods Data for this cross-sectional were sourced from 2003–2018 National Health Nutrition Examination Survey. Weighted multivariable regression analysis subgroup conducted estimate independent...
Corneal damage contributes to blindness in millions of people. Simulating natural corneas with artificial is challenging due material and manufacturing limitations, including poor mechanical properties, complex processes, ocular histocompatibility. In this study, electrospun micro-nanofibrous decellularized extracellular matrix (dECM) combined digital light processing 3D bioprinting validated as a bioartificial cornea for the first time. Electrospinning gives controllable shape, dECM,...
Background: The asymptomatic onset and extremely high mortality rate of aortic aneurysm (AA) highlight the urgency early detection timely intervention. alteration retinal vascular features (RVFs) can reflect systemic properties, be widely used as biomarker for cardiovascular disease risk prediction. Therefore, we aimed to investigate associations RVFs with AA its progression. Methods: In this prospective population-based cohort study, participants eligible fundus images without a history at...
ABSTRACT PURPOSE: To investigate the effect of pupil diameter on higher order aberration in myopic eyes. METHODS: One hundred and two eyes 51 normal subjects were evaluated with Nidek OPDScan. RESULTS: All types increased significantly increasing size (P<.001). However, optical aberrations had a less pronounced increase C 3 ^sup -1^ +1^, more 4 p 0 area (P<.05), 2nd coma (C 5 +1^) high astigmatism -2^, +2^, 8 +2^) larger pupU diameter. Compared each at mm, average root mean square...
OBJECTIVE—To assess the effects of adjunctive treatment with pramlintide, an analog β-cell hormone amylin, on 24-h glucose fluctuations and postprandial glucose, glucagon, triglyceride excursions in patients type 1 diabetes intensively treated continuous subcutaneous insulin infusion (CSII). RESEARCH DESIGN AND METHODS—In this study, 18 (16 whom could be evaluated) (age 44 ± 11 years, HbA1c 8.2 1.3% [mean SD]) were given mealtime injections 30 μg pramlintide t.i.d. for 4 weeks addition to...