A5063534485- Liver physiology and pathology
- Liver Disease Diagnosis and Treatment
- Drug-Induced Hepatotoxicity and Protection
- SARS-CoV-2 and COVID-19 Research
- Drug Transport and Resistance Mechanisms
- Ferroptosis and cancer prognosis
- Liver Disease and Transplantation
- Liver Diseases and Immunity
- Hedgehog Signaling Pathway Studies
- COVID-19 Clinical Research Studies
- Digestive system and related health
- Asthma and respiratory diseases
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Organ Transplantation Techniques and Outcomes
- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Bacillus and Francisella bacterial research
- Analytical Chemistry and Chromatography
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Animal Virus Infections Studies
- Macrophage Migration Inhibitory Factor
- Pharmacological Effects and Assays
- Cassava research and cyanide
- Monoclonal and Polyclonal Antibodies Research
Shanghai University of Traditional Chinese Medicine
2017-2024
Shuguang Hospital
2017-2024
Center for Excellence in Molecular Cell Science
2022-2024
Chinese Academy of Sciences
2022-2024
University of Chinese Academy of Sciences
2022
Shanghai Municipal Education Commission
2017-2019
Hepatocyte ferroptosis promotes the pathogenesis and progression of liver fibrosis. Salvianolic acid B (Sal B) exerts antifibrotic effects. However, pharmacological mechanism target has not yet been fully elucidated. In this study, fibrosis was induced by CCl4 in wild-type mice hepatocyte-specific extracellular matrix protein 1 (Ecm1)-deficient mice, which were separately treated with Sal B, ferrostatin-1, sorafenib or cilengitide. Erastin- CCl4-induced hepatocyte models without Ecm1 gene...
Activation of TGFB (transforming growth factor β) promotes liver fibrosis by activating hepatic stellate cells (HSCs), but the mechanisms activation are not clear. We investigated role ECM1 (extracellular matrix protein 1), which interacts with extracellular and structural proteins, in mouse livers.We performed studies C57BL/6J mice (controls), ECM1-knockout (ECM1-KO) mice, hepatocyte-specific knockout EMC1 (ECM1Δhep). or soluble TGFBR2 (TGFB receptor 2) were expressed livers after injection...
Advanced liver fibrosis can lead to cirrhosis, resulting in an accelerated risk of hepatocellular carcinoma and failure. Fuzheng Huayu formula (FZHY) is a traditional Chinese medicine treated China approved by State Food Drug Administration (NO: Z20050546), composed Salvia Miltiorrhiza bge., Prunus davidiana (Carr.) Franch., cultured Cordyceps sinensis (BerK.) Sacc. Mycelia, Schisandra chinensis (Turcz.) Baill., Pinus massoniana Lamb., Gynostemma pentaphyllum (Thunb.) Makino. However, the...
It is poorly understood what cellular types participate in ductular reaction (DR) and whether DR facilitates recovery from injury or accelerates hepatic fibrosis. The aim of this study to gain insights into the role progenitor cell (HPC)-originated during fibrotic progression.
Abstract Total astragalus saponins (TAS) are the main active components of astragali radix , and have potent anti‐hepatic fibrosis effect. However, therapeutic efficacy TAS their potential mechanisms in treatment primary sclerosing cholangitis (PSC) remain unclear. In this study, two mouse models PSC, including 3,5‐Diethoxycarbonyl‐1,4‐Dihydro‐2,4,6‐Collidine (DDC)‐induced PSC Mdr2 −/− spontaneous Tgr5 mice were used to investigate effect TAS. Treatment with TAS, particularly a dose 56...
Backgroud and aims: Ductular reaction (DR) is a common pathological change thought to have key role in the pathogenesis progression of liver fibrosis. Our previous study reported Gypenosides (GPs) ameliorated fibrosis, however, anti-fibrotic mechanisms GPs are still unclear. Methods: Liver fibrosis was induced rats by carbon tetrachloride combining with 2-acerylaminofluorene (CCl 4 /2-AAF), Mdr2 knockout ( −/− ) mice evaluate GPs. In vitro , WB-F344 cells, hepatic progenitor cells (HPCs)...
Liver fibrosis is a common pathological change in many chronic liver diseases. Activation of hepatic stellate cells (HSCs) the core event fibrosis. This study aimed to investigate role testicular orphan receptor 4 (TR4) activation HSCs.In vivo, bile duct ligation (BDL)-induced rat model was established, and expressions TR4 α-smooth muscle actin (α-SMA) tissues were detected. In vitro, knockdown overexpression JS-1 using lentiviral vectors constructed, TR4, α-SMA, Col-I, TGF-β1/smads retinoid...
Abstract Background: Advanced liver fibrosis can lead to cirrhosis, resulting in an accelerated risk of failure and hepatocellular carcinoma. It is necessary develop effective antifibrotic strategy. has been reported that Fuzheng Huayu formula (FZHY) had a remarkable anti-hepatic effect. Here, We obtain new anti-fibrotic composition, which consists the main active ingredients FZHY investigate its mechanism pharmacological action. Methods: The through quantitative analysis extracts...
A method for the determination of hydroxyproline (Hyp) in liver tissue mice by hydrophilic interaction chromatography-quadrupole/electrostatic field orbitrap high resolution mass spectrometry (HILIC-HRMS) was developed. The samples normal and fibrosis induced carbon tetrachloride were hydrolyzed concentrated hydrochloric acid. After filtrated diluted solution, diluent separated on an Hypersil GOLD HILIC column (100 mm×2.1 mm, 3 μm). Water-acetonitrile (28:72, v/v)were used as mobile phases...