A5101790009- Liver physiology and pathology
- Liver Disease Diagnosis and Treatment
- Drug-Induced Hepatotoxicity and Protection
- Liver Disease and Transplantation
- Pharmacological Effects of Natural Compounds
- Pharmacogenetics and Drug Metabolism
- Liver Diseases and Immunity
- Cancer, Lipids, and Metabolism
- Pediatric Hepatobiliary Diseases and Treatments
- Drug Transport and Resistance Mechanisms
- Traditional Chinese Medicine Analysis
- Organ Transplantation Techniques and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Cancer therapeutics and mechanisms
- Ginseng Biological Effects and Applications
- Effects and risks of endocrine disrupting chemicals
- Macrophage Migration Inhibitory Factor
- Pluripotent Stem Cells Research
- Ferroptosis and cancer prognosis
- Plant-based Medicinal Research
- Heavy Metal Exposure and Toxicity
- Cassava research and cyanide
- Traditional Chinese Medicine Studies
Jilin University
2025
China Medical University
2023-2025
Chengdu University of Traditional Chinese Medicine
2021-2025
Hunan Provincial People's Hospital
2025
Hunan Normal University
2025
State Key Laboratory of Respiratory Disease
2025
Guangzhou Medical University
2025
Shuguang Hospital
2015-2024
Shanghai University of Traditional Chinese Medicine
2015-2024
State Administration of Traditional Chinese Medicine of the People's Republic of China
2023-2024
Hepatocyte ferroptosis promotes the pathogenesis and progression of liver fibrosis. Salvianolic acid B (Sal B) exerts antifibrotic effects. However, pharmacological mechanism target has not yet been fully elucidated. In this study, fibrosis was induced by CCl4 in wild-type mice hepatocyte-specific extracellular matrix protein 1 (Ecm1)-deficient mice, which were separately treated with Sal B, ferrostatin-1, sorafenib or cilengitide. Erastin- CCl4-induced hepatocyte models without Ecm1 gene...
Two new Securinega alkaloids, virosaines A (1) and B (2), were isolated from the twigs leaves of Flueggea virosa. The structures absolute configurations elucidated by means NMR, X-ray diffraction, CD analyses. Compounds 1 2 represent first examples alkaloids bearing a 7-oxa-1-azabicyclo[3.2.1]octane ring system, whose plausible biogenetic pathways also proposed.
Abstract This study aims to systematically determine the activities and expressions of cytochrome P450s (CYP) in hepatocellular carcinoma (HCC) patients support their optimal use personalized treatment HCC. Activities seven major drug-metabolizing CYP enzymes (CYP1A2, 2A6, 2C8, 2C9, 2D6, 2E1, 3A4) were determined tumors pericarcinomatous tissues harvested from 26 with hepatitis B virus-positive HCC using probe substrates. Protein mRNA levels these CYPs also measured isotope label-free...
Although hepatic progenitor cells (HPCs) are known to contribute cholestatic liver fibrosis (CLF), how Notch signaling modulates the differentiation of HPCs cholangiocytes in CLF is unknown. Thus, using a rat model that induced by bile duct ligation, we inhibited with DAPT. In vivo, CK19, OV6, Sox9, and EpCAM expression was increased significantly. after DAPT treatment reduced blocked cholangiocyte proliferation CLF. vitro, WB-F344 cell line sodium butyrate resulted mRNA protein EpCAM, but...
How to achieve stable co-delivery of multiple phytochemicals is a common problem. This study focuses on the development, optimization and characterization Huanglian-HouPo extract nanoemulsion (HLHPEN), with components co-delivery, enhance anti-ulcerative colitis (UC) effects. The formulation HLHPEN was optimized by pseudo-ternary phase diagram combined Box-Behnken design. physicochemical properties were characterized, its anti-UC activity evaluated in DSS-induced UC mice model. Based...
Myocardial infarction represents a coronary artery ailment with the highest incidence and fatality rates among cardiovascular conditions. However, effective pharmacological interventions remain elusive. This study seeks to elucidate molecular mechanisms underlying effects of Ligusticum wallichii on myocardial through network pharmacology experimental validation. Initially, potential targets wallichii's active ingredients infarction-related were retrieved from databases. Subsequently, core...
Background: Ozone pollution has increased alongside China’s economic development, contributing to public health issues such as cardiovascular and cerebrovascular diseases. At present, the problem of an aging population is aggravated, which worth more attention in terms problems elderly people. Methods: This study employed a distributional lag nonlinear model (DLNM) with Poisson regression analyze impact ozone on disease mortality among Shenyang, China, from 2014 2018. In addition,...
BACKGROUND Esophageal and gastric variceal bleeding is a catastrophic complication of portal hypertension, most commonly caused by cirrhosis various etiologies. Although considerable body research has been conducted in this area, the complexity disease lack standardized treatment strategies have led to fragmented findings, insufficient information, systematic investigation. Bibliometric analysis can help clarify trends, identify core topics, reveal potential future directions. Therefore,...
Although Periplaneta americana L. and its modern preparation, Kangfuxin liquid, have been extensively applied for ulcerative diseases in gastrointestinal tract (e.g., gastric ulcer (GU) colitis, the effective components potential mechanisms) remain unclear. In accordance with accumulating research evidences, relieving/exacerbating of GU is noticeably correlated to focal tissue programmed cell death. Herein, gastro-protective effects extract (PAE) fraction were assessed vitro vivo, involving...
Abstract Background The limited therapeutic outcomes of atherosclerosis (AS) have allowed, traditional Chinese medicine has been well established as an alternative approach in ameliorating AS and associated clinical syndromes. Clinically, Tongsaimai tablet (TSMT), a commercial patent approved by CFDA, shows obvious effect on treatment. However, its effective mechanism quality control still need thorough urgent exploration. Methods mice were orally administered with TSMT their serum was...