A5049388814- Transplantation: Methods and Outcomes
- Lung Cancer Research Studies
- Immune cells in cancer
- Liver Disease Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Ferroptosis and cancer prognosis
- Renal Diseases and Glomerulopathies
- Cancer Cells and Metastasis
- Reproductive System and Pregnancy
- Respiratory viral infections research
- Folate and B Vitamins Research
- Traditional Chinese Medicine Analysis
- Mechanical Circulatory Support Devices
- Traditional Chinese Medicine Studies
- Lung Cancer Treatments and Mutations
- Brain Metastases and Treatment
- Organ Transplantation Techniques and Outcomes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Nanoparticle-Based Drug Delivery
- Bone and Joint Diseases
- Inflammation biomarkers and pathways
- COVID-19 Clinical Research Studies
- Pharmacological Effects of Natural Compounds
- Radiomics and Machine Learning in Medical Imaging
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
Wuxi People's Hospital
2012-2025
Nanjing Medical University
2012-2025
Jiangsu Province Hospital
2022-2024
Hunan Provincial Center for Disease Control and Prevention
2024
South China University of Technology
2024
Guangzhou First People's Hospital
2007-2024
Guangzhou Medical University
2007-2024
Chinese Academy of Sciences
2024
Chengdu Fifth People's Hospital
2024
Shanghai University of Traditional Chinese Medicine
2017-2023
Rationale: Hepatocellular carcinoma (HCC) is an aggressive malignant solid tumor wherein CDK1/PDK1/β-Catenin activated, suggesting that inhibition of this pathway may have therapeutic potential. Methods: CDK1 overexpression and clinicopathological parameters were analyzed. HCC patient-derived xenograft (PDX) models treated with RO3306 (4 mg/kg) or sorafenib (30 mg/kg), alone in combination. The relevant signaling was measured by western blot. Silencing shRNA corresponding inhibitors...
Abstract T cells modified with anti‐ CD 19 chimeric antigen receptor ( CAR ) containing either 28 or 4‐1 BB (also termed TNFRSF 9, 137) costimulatory signalling have shown great potential in the treatment of acute lymphoblastic leukaemia ALL ). However, difference between and ‐T has not been well elucidated clinical trials. In this study, we treated 10 relapsed refractory patients second generation ‐T. The first 5 were 28‐ other All response‐evaluable. Three achieved complete remission 1...
The development of safe and effective vaccines to respond COVID-19 pandemic/endemic remains a priority. We developed novel subunit protein-peptide vaccine candidate (UB-612) composed of: (i) receptor binding domain SARS-CoV-2 spike protein fused modified single-chain human IgG1 Fc; (ii) five synthetic peptides incorporating conserved helper cytotoxic T lymphocyte (Th/CTL) epitopes derived from structural proteins (three S2 subunit, one membrane nucleocapsid), universal Th peptide; (iii)...
Understanding cancer stem cell (CSC) maintenance pathways is critical for the development of CSC-targeting therapy. Here, we investigated functional role cyclin D1-dependent activation Smad2/3 and Smad4 in hepatocellular carcinoma (HCC) CSCs HCC primary tumors. Cyclin D1 sphere-derived xenograft tumor models were employed to evaluate therapeutic effects a Smad inhibitor combination with chemotherapy. overexpression confers stemness properties by enhancing single sphere formation, CD90+...
Echinacoside (ECH) is a phenylethanoid glycoside extracted from Chinese herbal medicine, Cistanches salsa . ECH possesses many biological properties, including anti‐inflammation, neural protection, liver and antitumor. In the current study, we aimed to explore effects of on hepatocellular carcinoma (HCC) underlying mechanisms. The results showed that could attenuate diethylnitrosamine (DEN)‐induced HCC in mice, exerted antiproliferative proapoptotic functions HepG2 cell line. exposure cells...
The present study aimed to determine the effects and mechanism of ChaC glutathione specific γ‑glutamylcyclotransferase 1 (CHAC1) on cell viability sensitivity prostate cancer cells docetaxel. Compared with non‑tumor human epithelial RWPE‑1 cells, mRNA protein levels CHAC1 significantly decreased in two lines, DU145 22RV1, as measured by quantitative polymerase chain reaction western blot analysis (P<0.05). (GSH) were inhibited following overexpression (P<0.01), while they increased...
Abstract Activated macrophages are commonly involved in the pathogenesis of inflammatory and autoimmune diseases have been frequently reported to overexpress FR-β. Although FR-targeted therapies aimed at eliminating activated shown promise for treating diseases, little work has performed evaluate whether other hematopoietic cells might also express Analysis peripheral blood with a mAb human FR-β reveals that only monocytes Molecular characterization these circulating further demonstrates...
Activated macrophages overexpress a receptor for the vitamin folic acid termed folate β (FR-β). Because conjugation of to low molecular weight drugs, genes, liposomes, nanoparticles, and imaging agents has minor effects on FR binding, can be exploited target both therapeutic activated without promoting their uptake by other healthy cells. In this paper, we characterize internalization, recycling kinetics FR-β in inflamed tissues rats with adjuvant-induced arthritis. Our results demonstrate...
Background. Primary graft dysfunction (PGD) develops within 72 h after lung transplantation (Lung Tx) and greatly influences patients’ prognosis. This study aimed to establish an accurate machine learning (ML) model for predicting grade 3 PGD (PGD3) Lung Tx. Methods. retrospective incorporated 802 patients receiving Tx between July 2018 October 2023 (640 in the derivation cohort 162 external validation cohort), 640 were randomly assigned training internal cohorts a 7:3 ratio. Independent...
// Ying Ye 1,* , Ling Xiao Su-Juan Wang 1 Wei Yue Qiao-Shan Yin Meng-Yao Sun 1,2 Xia 3 Zhi-Yi Shao and Hong Zhang Central Laboratory, Shanghai Seventh People’s Hospital, Shanghai, PR China 2 Department of Pharmaceutical Botany, School Pharmacy, Second Military Medical University, Nuclear Medicine, * These authors have contributed equally to this work Correspondence to: Zhang, email: Xia, Keywords : colorectal cancer; REG3A; AKT; ERK1/2 Received June 14, 2015 Accepted November 25,...
EC20, a folate-targeted 99mTc based radioimaging agent with high folate receptor (FR) binding affinity, has been used for both the diagnosis and staging of FR positive malignancies (currently in phase III trials) also localization inflamed lesions characterized by accumulation FR+ macrophages. Because recent evidence suggested that macrophages might accumulate at sites infectious disease, this study evaluated whether EC20 prove similarly useful imaging bacterial infection foci. Using gamma...
Murine RAW 264.7 cells were exposed to spheroidal core–shell Fe3O4@Au nanoparticles (SCS-NPs, ca. 34 nm) or nanostars (NSTs, 100 in the presence of bovine serum albumin, with variable effects observed after macrophagocytosis. Uptake SCS-NPs caused macrophages adopt a rounded, amoeboid form, accompanied by an increase surface detachment. In contrast, uptake multibranched NSTs did not induce gross changes macrophage shape adhesion, but correlated instead cell enlargement and signatures...
Abstract Background Apelin is a peptide ligand of the G‐protein‐coupled receptor APJ and exhibits anti‐diabetes anti‐heart failure activities. However, short serum half‐life apelin limits its potential clinical applications. This study aimed to develop long‐acting analog. Methods To extend apelin's in vivo half‐life, we made recombinant protein by fusing IgG Fc fragment apelin‐13 (Fc‐apelin‐13), conducted pharmacokinetics studies mice, determined vitro biological activities suppressing...
Cervical cancer is the second most common female carcinoma. Current therapies are often unsatisfactory, especially for advanced stage patients. The aim of this study was to explore effects tatariside G (TG) on apoptosis in human cervical HeLa cells and possible mechanism action involved. An MTT assay employed evaluate cell viability. Hoechst 33258 staining flow cytometry (FCM) assays were used detect apoptosis. protein expression phosphorylated JNK, P38, ERK Akt cleaved caspase-3 caspase-9...