A5100677513- Cancer-related molecular mechanisms research
- Cancer Research and Treatments
- Cancer Cells and Metastasis
- Antibiotic Resistance in Bacteria
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Protein Degradation and Inhibitors
- Cancer, Lipids, and Metabolism
- Cancer therapeutics and mechanisms
- Bacteriophages and microbial interactions
- PI3K/AKT/mTOR signaling in cancer
- Neutropenia and Cancer Infections
- Archaeological Research and Protection
- Salivary Gland Disorders and Functions
- Cultural Heritage Materials Analysis
- Bacterial biofilms and quorum sensing
- Mechanical Circulatory Support Devices
- Infections and bacterial resistance
- Transplantation: Methods and Outcomes
- Bacterial Identification and Susceptibility Testing
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
Wuxi People's Hospital
2023-2025
Nanjing Medical University
2023-2025
Zhengzhou University
2021-2024
Minzu University of China
2020-2024
Jiangsu Province Hospital
2023-2024
Renmin University of China
2024
Henan Cancer Hospital
2023-2024
Chinese PLA General Hospital
2023
Johns Hopkins University
2022
Harbin Medical University
2015-2021
Abstract As a novel form of regulated cell death (RCD), disulfidptosis offering significant opportunity in better understanding tumor pathogenesis and therapeutic strategies. Long non-coding RNAs (lncRNAs) regulate the biology functions cells by engaging with range targets. However, prognostic value disulfidptosis-related lncRNAs (DRlncRNAs) lung adenocarcinoma (LUAD) remains unclear. Therefore, our study aimed at establishing model for LUAD patients based on DRlncRNAs. RNA-seq data clinical...
Neural stem cells are self-renewing, multipotent and undifferentiated precursors that retain the capacity for differentiation into both glial (astrocytes oligodendrocytes) neuronal lineages. offer cell-based therapies neurological disorders such as Alzheimer's disease, Parkinson's Huntington's disease spinal cord injuries. However, their cellular behavior is poorly understood. MicroRNAs (miRNAs) a class of small noncoding RNAs involved in cell development, proliferation through regulating...
This study aims to investigate the risk factors for carbapenem-resistant Pseudomonas aeruginosa bloodstream infection (CRPA-BSI) and identify predictors of outcomes among patients with P. (PA-BSI). A retrospective cohort was conducted on PA-BSI at Henan Cancer Hospital from 2013 2022. Among 503 incidences analyzed, 15.1% them were CRPA strains. Age, ANC<100/mmc, receiving antifungal prophylaxis, exposure carbapenems within previous 90 days onset BSI, allogeneic HSCT (allo-HSCT) associated...
Background. Primary graft dysfunction (PGD) develops within 72 h after lung transplantation (Lung Tx) and greatly influences patients’ prognosis. This study aimed to establish an accurate machine learning (ML) model for predicting grade 3 PGD (PGD3) Lung Tx. Methods. retrospective incorporated 802 patients receiving Tx between July 2018 October 2023 (640 in the derivation cohort 162 external validation cohort), 640 were randomly assigned training internal cohorts a 7:3 ratio. Independent...
Mediator complex subunit 12 (MED12) is an essential hub for transcriptional regulation, in which mutations and overexpression were reported to be associated with several kinds of malignancies. Nevertheless, the role MED12 non-small cell lung cancer (NSCLC) remains elucidated. mutation was detected by Next-generation sequencing. The expression 179 human NSCLC tissue samples 73 corresponding adjacent normal measured immunohistochemistry (IHC). CRISPR-Cas9 used knock out PC9 SPC-A1 cells....
To analyze the clinical characteristics and prognostic risk factors of carbapenem-resistant Pseudomonas aeruginosa (CRPA) bloodstream infections in patients with hematologic malignancies.Medical records drug susceptibility data malignancies complicated by CRPA admitted to Cancer Hospital Zhengzhou University between January 1, 2018, December 31, 2022, were retrospectively analyzed.A total 64 included study, a mortality rate 37.5% (24/64) at 28 days after occurrence infection. In Cox...
Abstract Background Studies have demonstrated that long noncoding RNAs (lncRNAs) essential impacts on the development of atherosclerosis (AS). This study aimed to identify role and functional mechanism lncRNA CASC2 in migration vascular smooth muscle cells (VSMCs). Method The serum 40 pairs AS patients healthy volunteers were collected expression was evaluated. qRT-PCR western blotting carried out examine levels at mRNA protein level, repectively. Cell proliferation assay, colony formation...
Trauma is statistically a significant cause of mortality among patients across countries. Nevertheless, the precise correlation between genetic diagnostic markers and intricate mechanism trauma remains indistinct. Our study exclusively centered on selected three trauma-related datasets from Gene Expression Omnibus (GEO) database, all which had blood samples collected within post-traumatic 12 h. Differential gene screening, WGCNA Cytoscape software were employed to analyze two datasets, with...
MicroRNA-1207-5p (MiR-1207-5p) has been identified as a tumor suppressor in many types of cancer. However, less research done with respect to the role miR-1207-5p colorectal cancer (CRC). The aim our study was analyze CRC.Total RNA extracted from clinical specimens and CRC cell line, expression examined by real-time PCR (q-PCR). human lines were transfected mimic, negative control (NC). Cell Counting Kit-8 (CCK-8) assays performed measure viability. colony formation assay carried out clone...
Background: Emergence of bla KPC and NDM co-harboring Klebsiella pneumoniae has escalated the threat Carbapenem-resistant (CRKP) to healthcare. It remains unknown prevalence molecular characteristics CRKP co-producing NDMs carbapenemases in Henan. Methods Results: Twenty-seven strains isolated from different times were selected randomly affiliated cancer hospital Zhengzhou University January 2019 2021, among which one KPC-2 NDM-5 positive named K9 was an abdominal pus sample a 63-year-old...
MicroRNA-1207-5p (miR-1207-5p) has been identified as a tumor suppressor in many types of cancer. In our previous research, we found that the expression miR-1207-5p cancer tissues and cell lines were both down-regulated, may function colorectal (CRC). However, less research done with respect to plasma CRC or adenoma (CRA). There was no regarding diagnostic ability nor on prognostic value CRC. We conducted preliminary study miRNA-1207-5p non-invasive biomarker CRC.Plasma quantified by qRT-PCR...
Abstract The immune system is increasingly recognized as an important regulator of tissue repair. We developed a regenerative immunotherapy from the helminth Schistosoma mansoni soluble egg antigen (SEA) to stimulate production interleukin (IL)-4 and other type 2-associated cytokines without negative infection-related sequelae. SEA (rSEA) applied murine muscle injury induced accumulation IL-4 expressing T helper cells, eosinophils, regulatory decreased expression IL-17A in gamma delta (γδ)...
<p>Supplementary Table S1. Acute leukemia patient characteristics.</p>
<p>Supplementary Table S2. Primer sequences for PCR.</p>
<p>Supplementary Figure S4. A representative Western blot of the effect afatinib on AKT and ERK 1/2 phosphorylation.</p>
<p>Supplementary Table S1. Acute leukemia patient characteristics.</p>
<p>Supplementary Table S2. Primer sequences for PCR.</p>
<p>Supplementary Figure S4. A representative Western blot of the effect afatinib on AKT and ERK 1/2 phosphorylation.</p>
Abstract Background As a novel form of regulated cell death (RCD), disulfidptosis has been reported recently, which brought the significant probability in better understanding for pathogenesis and therapeutic strategies tumors. Long non-coding RNAs (LncRNAs) regulate viability tumor cells by engaging with range targets, including DNA, RNA, proteins. Nonetheless, about prognostic value disulfidptosis-related LncRNAs (DRlncRNAs) lung adenocarcinoma (LUAD) remains incomplete. Therefore, our...