A5071756638- Single-cell and spatial transcriptomics
- Telomeres, Telomerase, and Senescence
- Parasitic Infections and Diagnostics
- Genetics, Aging, and Longevity in Model Organisms
- Parasites and Host Interactions
- Congenital heart defects research
- Gastrointestinal motility and disorders
- Mesenchymal stem cell research
- Planarian Biology and Electrostimulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Clostridium difficile and Clostridium perfringens research
- Gut microbiota and health
- Extracellular vesicles in disease
- Cancer Immunotherapy and Biomarkers
- Parasitic Diseases Research and Treatment
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- T-cell and B-cell Immunology
Johns Hopkins University
2022-2025
University of Baltimore
2024
Johns Hopkins Medicine
2022-2023
Abstract The gut microbiota influences systemic immunity and the function of distal tissues, including brain, liver, skin, lung, muscle. However, role in foreign body response (FBR) fibrosis around medical implants is largely unexplored. To investigate this connection, we perturbed homeostasis murine via enterotoxigenic Bacteroides fragilis (ETBF) infection implanted synthetic polymer polycaprolactone (PCL) into a muscle injury. ETBF mice led to increased neutrophil γδ T cell infiltration...
The immune system is increasingly recognized as an important regulator of tissue repair. We developed a regenerative immunotherapy from the helminth Schistosoma mansoni soluble egg antigen (SEA) to stimulate production interleukin (IL)-4 and other type 2-associated cytokines without negative infection-related sequelae. SEA (rSEA) applied murine muscle injury induced accumulation IL-4-expressing T helper cells, eosinophils, regulatory cells decreased expression IL-17A in gamma delta (γδ)...
Aging is associated with immunological changes that compromise response to infections and vaccines, exacerbate inflammatory diseases can potentially mitigate tissue repair. Even so, age-related the immune damage regenerative medicine therapies remain unknown. Here, it characterized how aging induces in signatures inhibit repair therapeutic a clinical biological scaffold derived from extracellular matrix. Signatures of inflammation interleukin (IL)-17 signaling increased injury treatment both...
Abstract Pancreatic Ductal Adenocarcinoma (PDAC) is a deadly cancer with low tumor mutational burden that leads to the generation of few neo-epitopes derived from mutated genes can be recognized by cytotoxic T cells. The immunosuppressive microenvironment PDAC comprises suppressive cell populations include myeloid cells, associated fibroblast subpopulations, and regulatory cells reduce infiltration function. We have developed murine personalized vaccine enhance function against PDAC, PancVAX...
Abstract Aging is associated with immunological changes that compromise response to infections and vaccines, exacerbate inflammatory diseases could potentially mitigate tissue repair. Even so, age-related the immune damage regenerative medicine therapies remain unknown. Here, we characterized how aging induces senescence inhibit repair therapeutic a clinical biological scaffold derived from extracellular matrix. Tissue signatures of inflammation interleukin (IL)-17 signaling increased injury...
Abstract Senescent cells (SnCs) contribute to normal tissue development and repair but accumulate with aging where they are implicated in a number of pathologies diseases. Despite their pathological role therapeutic interest, SnC phenotype function vivo remains unclear due the challenges identifying isolating these rare cells. Here, we developed an -derived senescence gene expression signature using model foreign body response (FBR) fibrosis p16 Ink4a - reporter mouse, cell cycle inhibitor...
Abstract The immune system is increasingly recognized as an important regulator of tissue repair. We developed a regenerative immunotherapy from the helminth Schistosoma mansoni soluble egg antigen (SEA) to stimulate production interleukin (IL)-4 and other type 2-associated cytokines without negative infection-related sequelae. SEA (rSEA) applied murine muscle injury induced accumulation IL-4 expressing T helper cells, eosinophils, regulatory decreased expression IL-17A in gamma delta (γδ)...
Abstract Cellular senescence is a state of permanent growth arrest that plays an important role in wound healing, tissue fibrosis, and tumor suppression. Despite senescent cells’ (SnC) pathological therapeutic interest, their phenotype vivo remains poorly defined. Here, we developed vivoderived signature using foreign body response (FBR) fibrosis model SnC reporter mouse. We identified pericytes “cartilage-like” fibroblasts as defined cell typespecific associated secretory phenotypes (SASP)....