A5046043788- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- 3D Printing in Biomedical Research
- biodegradable polymer synthesis and properties
- Bone Tissue Engineering Materials
- Biomedical and Engineering Education
- Pluripotent Stem Cells Research
- Wound Healing and Treatments
- Immune cells in cancer
- Innovative Teaching Methods
- Telomeres, Telomerase, and Senescence
- Neuroscience and Neural Engineering
- Single-cell and spatial transcriptomics
- Teaching and Learning Programming
- Career Development and Diversity
- Congenital heart defects research
- Immunotherapy and Immune Responses
- Carbon dioxide utilization in catalysis
- Cancer Cells and Metastasis
- Graphene and Nanomaterials Applications
- Problem and Project Based Learning
- Engineering Education and Curriculum Development
- Innovative Microfluidic and Catalytic Techniques Innovation
- Planarian Biology and Electrostimulation
- Cancer, Stress, Anesthesia, and Immune Response
Dalhousie University
2022-2025
Nova Scotia Health Authority
2023-2025
Johns Hopkins University
2021-2024
Johns Hopkins Medicine
2022-2023
University of Toronto
2015-2021
University Health Network
2019-2021
Western University
2020
Vanderbilt University
2020
Ted Rogers Centre for Heart Research
2020
Toronto General Hospital
2020
Abstract Tumor progression relies on the interaction between neoplastic epithelial cells and their surrounding stromal partners. This cell cross‐talk affects development, ultimately heterogeneity impacts drug efficacy. To mimic this evolving paradigm, 3D vascularized pancreatic adenocarcinoma tissue is microengineered in a tri‐culture system composed of patient‐derived organoids, human fibroblasts, endothelial perfusable platform, situated 96‐well plate. Through synergistic engineering,...
Myocardial fibrosis is a severe global health problem due to its prevalence in all forms of cardiac diseases and direct role causing heart failure. The discovery efficient antifibrotic compounds has been hampered the lack physiologically relevant disease model. Herein, we present model human myocardial use it establish compound screening system. In Biowire II platform, tissues are suspended between pair poly(octamethylene maleate (anhydride) citrate) (POMaC) wires. Noninvasive functional...
Abstract Biomaterials are becoming increasingly crucial for healthcare solutions, with extensive use in the field of tissue engineering and drug delivery. After implantation, biomaterials trigger an immune response characterized by recruitment bone‐marrow‐derived proinflammatory macrophages that develop as most abundant cell type surrounding biomaterial. Chronic activation this recruited macrophage population induces a foreign body reaction consequent biomaterial rejection. However,...
Polyester biomaterials are used in tissue engineering as scaffolds for implantation of tissues developed vitro. An ideal biodegradable elastomer cardiac exhibits a relatively low Young's modulus, with high elongation and tensile strength. Here we describe novel polyester biomaterial that improved elastic properties applications. We synthesized poly(octamethylene maleate (anhydride) 1,2,4-butanetricarboxylate) (124 polymer) prepolymer gel one-step polycondensation reaction. The was then...
Abstract Itaconate (IA) is an endogenous metabolite and a potent regulator of the innate immune system. Its use in immunomodulatory therapies has faced limitations due to inherent challenges achieving controlled delivery requirements for high extracellular concentrations achieve internalization highly polar small molecule its intracellular therapeutic activity. Microparticle (MP)-based strategies are promising approach metabolites through macrophage phagocytosis subsequent polymer...
Abstract Drug screening with simplified 2D cell culture and relevant animal testing fail to predict clinical outcomes. With the rising cost of drug development, predictive 3D tissue models human cells are in urgent demand. Establishing vascular perfusion tissues has always been a challenge, but it is necessary mimic transport capture complex interorgan crosstalk. Here, versatile multiwell plate presented empowered by built‐in microfabricated scaffolds that define space support self‐assembly...
Bioelastomers have been extensively used in tissue engineering applications because of favorable mechanical stability, tunable properties, and chemical versatility. As these materials generally possess low elastic modulus relatively long gelation time, it is challenging to 3D print them using traditional techniques. Instead, the field printing has focused preferentially on hydrogels rigid polyester materials. To develop a versatile approach for elastomers, we freeform reversible embedding...
Biomaterial composition contributes to local, regional, and systemic alterations in B cells.
Engineering mature tissues requires a guided assembly of cells into organized three-dimensional (3D) structures with multiple cell types. Guidance is usually achieved by microtopographical scaffold cues or cell-gel compaction. The individual units functional 3D often time-consuming, relying on ingrowth and matrix remodeling, whereas disassembly an invasive method that includes either dissolution mechanical cutting. We invented Tissue-Velcro, bio-scaffold microfabricated hook loop system....
Abstract Due to escalating drug developmental costs and limitations of cardiotoxicity screening, there is an urgent need develop robust in vitro 3D tissue culture platforms that can both facilitate the human cardiac tissues provide noninvasive functional readouts predictive clinical settings. However, such commonly require complex fabrication procedures are difficult scale up high‐throughput testing platforms. Here, innovative multimaterial processing into a scalable platform proposed format...
Abstract Synthetic polyester elastomeric constructs have become increasingly important for a range of healthcare applications, due to tunable soft elastic properties that mimic those human tissues. A number these require intricate mechanical design achieve material with controllable curing. Here, the synthesis and characterization poly(itaconate‐ co‐ citrate‐ octanediol) (PICO) is presented, which exhibits formation networks through radical crosslinking itaconate in polymer backbone viscous...
Non-degradable polymeric implantable medical devices are a mainstay of modern healthcare but can frequently lead to severe complications. These complications largely attributable the foreign body response (FBR), which is characterized by excessive inflammation and fibrosis in implanted materials. The pathologic mechanisms underpinning FBR remain elusive; however, metabolism increasingly regarded as critical regulator innate immune function. We conducted comprehensive metabolic profiling...
Pathological fibrosis is a chronic disease, characterized by excessive extracellular matrix deposition, that remains significant global health challenge. Despite its prevalence, current antifibrotic therapies are limited due to the complex interplay and signaling of profibrotic macrophages fibroblast cells underlies fibrotic tissue microenvironments. This study investigates novel approach combat fibrosis, harnessing properties endogenous metabolite itaconate (IA) target pathological...