A5091670567- Cardiac Fibrosis and Remodeling
- Tissue Engineering and Regenerative Medicine
- Cardiovascular Function and Risk Factors
- Technology Adoption and User Behaviour
- Cell Adhesion Molecules Research
- Acute Myocardial Infarction Research
- Angiogenesis and VEGF in Cancer
- Electrospun Nanofibers in Biomedical Applications
- Education and Islamic Studies
- Vascular Procedures and Complications
- Nitric Oxide and Endothelin Effects
- Cardiac Valve Diseases and Treatments
- Halal products and consumer behavior
- 3D Printing in Biomedical Research
- Coronary Interventions and Diagnostics
- Diabetes Treatment and Management
- Islamic Finance and Banking Studies
- Diabetes and associated disorders
- Long-Term Effects of COVID-19
- Immune cells in cancer
- Cancer, Hypoxia, and Metabolism
- Digital Marketing and Social Media
- Cardiovascular Disease and Adiposity
- Atherosclerosis and Cardiovascular Diseases
- Venous Thromboembolism Diagnosis and Management
Toronto General Hospital
2015-2024
University of Toronto
2011-2024
University Health Network
2015-2024
Jagannath University
2023-2024
Ted Rogers Centre for Heart Research
2016-2023
National Institute of Cardiovascular Diseases
2015-2023
University of Technology Malaysia
2022-2023
Toronto General Hospital Research Institute
2010-2022
Dhaka Medical College and Hospital
2020-2021
Médecins Sans Frontières
2020
Resident macrophages orchestrate homeostatic, inflammatory, and reparative activities. It is appreciated that different tissues instruct specialized macrophage functions. However, individual contain heterogeneous subpopulations, how these subpopulations are related unclear. We asked whether common transcriptional functional elements could reveal an underlying framework across tissues. Using single-cell RNA sequencing random forest modeling, we observed four genes predict three subsets were...
Chronic exposure to high glucose leads diabetic nephropathy characterized by increased mesangial matrix protein (e.g., collagen) accumulation. Altered cell signaling and gene expression accompanied oxidative stress have been documented. The contribution of the tyrosine kinase, c-Src (Src), which is sensitive stress, was examined. Cultured rat cells were exposed (25 mmol/L) in presence absence Src inhibitors (PP2, SU6656), small interfering RNA (siRNA), tumor necrosis factor-α-converting...
Expression of thioredoxin-interacting protein (TxNIP), an endogenous inhibitor the thiol oxidoreductase thioredoxin, is augmented by high glucose (HG) and promotes oxidative stress. We previously reported that TxNIP-deficient mesangial cells showed protection from HG-induced reactive oxygen species, mitogen-activated kinase phosphorylation, collagen expression. Here, we investigated potential role TxNIP in pathogenesis diabetic nephropathy (DN) vivo. Wild-type (WT) control, TxNIP−/−,...
Mechanisms mediating the cardioprotective actions of glucagon-like peptide 1 (GLP-1) were unknown. Here, we show in both ex vivo and models ischemic injury that treatment with GLP-1(28-36), a neutral endopeptidase-generated (NEP-generated) metabolite GLP-1, was as GLP-1 abolished by scrambling its amino acid sequence. GLP-1(28-36) enters human coronary artery endothelial cells (caECs) through macropinocytosis acts directly on mouse smooth muscle (caSMCs) caECs, resulting soluble adenylyl...
Background— Sphingosine-1-phosphate (S1P) signaling is a central regulator of resistance artery tone. Therefore, S1P levels need to be tightly controlled through the delicate interplay its generating enzyme sphingosine kinase 1 and functional antagonist phosphohydrolase-1. The intracellular localization phosphohydrolase-1 necessitates import extracellular into compartment before degradation. present investigation proposes that cystic fibrosis transmembrane conductance transports hence...
Background— Heart failure is associated with neurological deficits, including cognitive dysfunction. However, the molecular mechanisms underlying reduced cerebral blood flow in early stages of heart failure, particularly when pressure minimally affected, are not known. Methods and Results— Using a myocardial infarction model mice, we demonstrate tumor necrosis factor-α (TNFα)–dependent enhancement posterior artery tone that reduces before any overt changes brain structure function. TNFα...
The current research aims to investigate various factors that influence consumers’ intention of buying foreign products. data were collected by means self-structured questionnaires from a total 260 Bangladeshi consumers residing in the two major cities country, Dhaka and Chittagong. At initial stage, statistical analyses, particularly descriptive analysis as well exploratory factor analysis, conducted using SPSS, after which structural equation modeling was run AMOS. findings have...
Objective To understand the molecular pathways underlying cardiac preconditioning effect of short-term caloric restriction (CR). Background Lifelong CR has been suggested to reduce incidence cardiovascular disease through a variety mechanisms. However, prolonged adherence life-style is difficult. Here we reveal that are modulated by CR, which associated with protection mouse heart from ischemia. Methods Male 10-12 wk old C57bl/6 mice were randomly assigned an ad libitum (AL) diet free access...
Maintaining macrophage (MΦ) heterogeneity is critical to ensure intestinal tissue homeostasis and host defense. The gut microbiota factors are thought synergistically guide MΦ development, although the exact nature, regulation, location of such collaboration remain unclear. Here, we report that microbial biochemical energy metabolism promotes colony-stimulating factor 2 (CSF2) production by group 3 innate lymphoid cells (ILC3s) within solitary isolated tissues (SILTs) in a cell-extrinsic,...
Hydrogels are being actively investigated for direct delivery of cells or bioactive molecules to the heart after myocardial infarction (MI) prevent cardiac functional loss. We postulate that immobilization prosurvival angiopoietin-1-derived peptide, QHREDGS, a chitosan-collagen hydrogel could produce clinically translatable thermoresponsive attenuate post-MI remodeling.
This is the first preclinical study to examine impact of ovary-intact menopause [accelerated ovarian failure (AOF)] on HFpEF. Echocardiography young female mice revealed early evidence diastolic and systolic cardiac dysfunction apparent only strain imaging in HFpEF only, AOF or combination. Surprisingly, did not exacerbate phenotype. Results middle-aged “old” females also showed no interaction between and, importantly, cardiovascular from AOF.
Background: Inferior myocardial infarction (MI) often results from right coronary artery (RCA) occlusion, with lesion location affecting infarct severity and outcomes. ST-segment elevation is a key prognostic marker, but its relationship RCA sites remains underexplored, particularly in Bangladesh. This study investigates the association between magnitude (proximal, mid, distal) their impact on in-hospital complications. Methods Materials: observational at National Institute of Cardiovascular...
Background: Acute kidney injury (AKI) is a significant complication in percutaneous coronary intervention (PCI) patients. Periprocedural bleeding and vascular access site complications are emerging risk factors for post-PCI AKI. Recent studies suggest that transradial PCI has lower incidence of AKI compared to transfemoral PCI, attributed reduced complications. This study aimed compare the acute following between approaches. Methods: cross-sectional included 200 ischemic heart disease...
Acute myocardial infarction (MI) leads to fibrosis and severe left ventricular wall thinning. Enhancing vascularization within the infarct reduces cell death maintains a thick wall, which is essential for proper cardiac function. Here, we evaluated controlled delivery of thymosin β4 (Tβ4), supports cardiomyocyte survival by inducing upregulating Akt activity, in treatment MI.
Heart failure (HF) and subarachnoid hemorrhage (SAH) chronically reduce cerebral perfusion, which negatively affects clinical outcome. This work demonstrates a strong relationship between artery cystic fibrosis transmembrane conductance regulator (CFTR) expression altered cerebrovascular reactivity in HF SAH. In SAH, CFTR corrector compounds (C18 or lumacaftor) normalize pathological alterations expression, vascular reactivity, without affecting systemic hemodynamic parameters. normalization...