A5002091001- Diabetes and associated disorders
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Cardiac Fibrosis and Remodeling
- Immunotherapy and Immune Responses
- Pancreatic function and diabetes
- Phagocytosis and Immune Regulation
- Cell Adhesion Molecules Research
- Adipokines, Inflammation, and Metabolic Diseases
- Long-Term Effects of COVID-19
- Fatty Acid Research and Health
- Immune cells in cancer
- Atherosclerosis and Cardiovascular Diseases
- 3D Printing in Biomedical Research
- Hippo pathway signaling and YAP/TAZ
- COVID-19 Clinical Research Studies
- Diabetes Management and Research
- Signaling Pathways in Disease
- IL-33, ST2, and ILC Pathways
- Infant Nutrition and Health
- Nanoparticle-Based Drug Delivery
- Cellular Mechanics and Interactions
- Viral Infections and Immunology Research
- Inflammasome and immune disorders
- Extracellular vesicles in disease
University of Alberta
2021-2024
Diabetes Canada
2024
University Health Network
2015-2019
Toronto General Hospital
2017-2019
University of Toronto
2018
University of Calgary
2010-2017
Center of Regenerative Medicine in Barcelona
2010
Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol
2009
Universitat Autònoma de Barcelona
2009
Banc de Sang i Teixits
2009
Abstract The intestinal immune system is emerging as an important contributor to obesity-related insulin resistance, but the role of B cells in this context unclear. Here, we show that high fat diet (HFD) feeding alters IgA + and a critical regulator glucose homeostasis. Obese mice have fewer less secretory IgA-promoting mediators. HFD-fed IgA-deficient dysfunctional metabolism, phenotype can be recapitulated by adoptive transfer intestinal-associated pan-B cells. Mechanistically, crucial...
Stiffness in the tissue microenvironment changes most diseases and immunological conditions, but its direct influence on immune system is poorly understood. Here, we show that static tension impacts cell function, maturation, metabolism. Bone-marrow-derived and/or splenic dendritic cells (DCs) grown vitro at physiological resting stiffness have reduced proliferation, activation, cytokine production compared with under higher stiffness, mimicking fibro-inflammatory disease. Consistently, DCs...
Abstract Background/objectives Low-grade chronic inflammation in visceral adipose tissue and the intestines are important drivers of obesity associated insulin resistance. Bioactive compounds derived from plants an source potential novel therapies for treatment diseases. In search new immune based treatments resistance, we screened relevant anti-inflammatory properties 20 plant-based extracts. Methods We extracts to assess preferential production IL-10 compared TNFα, specifically targetting...
Summary Dendritic cells (DCs) are powerful antigen-presenting capable of maintaining peripheral tolerance. The possibility to generate tolerogenic DCs opens new therapeutic approaches in the prevention or remission autoimmunity. There is currently no treatment inducing long-term tolerance and type 1 diabetes (T1D), a disease caused by autoimmunity towards β cells. An ideal immunotherapy should inhibit autoimmune attack, avoid systemic side effects allow islet regeneration. Apoptotic – source...
Cardiac manifestations of COVID-19 in humans are mirrored the SARS-CoV-2 hamster model, recapitulating myocardial damage, ACE2 downregulation, and a consistent pattern immune cell infiltration independent viral dose variant. Therefore, model is valid approach to study therapeutic strategies for COVID-19-related heart disease.
IL-2 plays a critical role in both effector T-cell development and FoxP3(+) CD4(+) Treg-cell homeostasis. A reduction Il2 transcription results impaired recruitment function, accounts for the association between murine type 1 diabetes (T1D). The progression of T1D elicits disease-countering negative feedback regulatory loop that involves differentiation low-avidity autoreactive CD8(+) T cells into memory-like autoregulatory Th-dependent manner. Since these auto-regulatory express IL-2Rβ...
12,13-dihydroxy-9z-octadecenoic acid (12,13-DiHOME) is a linoleic diol derived from cytochrome P-450 (CYP) epoxygenase and epoxide hydrolase (EH) metabolism. 12,13-DiHOME associated with inflammation mitochondrial damage in the innate immune response, but how contributes to these effects unclear. We hypothesized that enhances macrophage through on NOD-like receptor protein 3 (NLRP3) inflammasome activation. To test this hypothesis, we utilized human monocytic THP1 cells differentiated into...
Polymorphisms in MHC class II molecules, particular around β-chain position-57 (β57), afford susceptibility/resistance to multiple autoimmune diseases, including type 1 diabetes, through obscure mechanisms. Here, we show that the antidiabetogenic molecule I-A b affords diabetes resistance by promoting differentiation of MHC-promiscuous autoreactive CD4 + T cells into disease-suppressing natural regulatory cells, a β56–67-regulated manner. We compared tolerogenic and properties CD11c...