A5022099725- Cardiac Fibrosis and Remodeling
- Transplantation: Methods and Outcomes
- Cell Adhesion Molecules Research
- Ubiquitin and proteasome pathways
- Single-cell and spatial transcriptomics
- Retinopathy of Prematurity Studies
- Signaling Pathways in Disease
- RNA Interference and Gene Delivery
- Renal Transplantation Outcomes and Treatments
- Tissue Engineering and Regenerative Medicine
- Diabetes and associated disorders
- T-cell and B-cell Immunology
- Electrolyte and hormonal disorders
- Pharmacogenetics and Drug Metabolism
- Immune cells in cancer
- Oral Health Pathology and Treatment
- Cancer Immunotherapy and Biomarkers
- Viral Infections and Immunology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiovascular Disease and Adiposity
- Dermatological and COVID-19 studies
- Retinal Development and Disorders
- Heart Rate Variability and Autonomic Control
- Systemic Lupus Erythematosus Research
- Inflammatory mediators and NSAID effects
University Health Network
2018-2025
Toronto General Hospital
2018-2025
Ted Rogers Centre for Heart Research
2021-2022
McMaster University
2015-2016
Dalhousie University
2008-2015
Population Health Research Institute
2015
Hamilton Health Sciences
2015
Resident macrophages orchestrate homeostatic, inflammatory, and reparative activities. It is appreciated that different tissues instruct specialized macrophage functions. However, individual contain heterogeneous subpopulations, how these subpopulations are related unclear. We asked whether common transcriptional functional elements could reveal an underlying framework across tissues. Using single-cell RNA sequencing random forest modeling, we observed four genes predict three subsets were...
Mutations in genes that code for components of the Norrin-FZD4 ligand-receptor complex cause inherited childhood blinding disorder familial exudative vitreoretinopathy (FEVR). Statistical evidence from studies patients at risk acquired disease retinopathy prematurity (ROP) suggest rare polymorphisms these same increase developing severe ROP, implying decreased activity predisposes to more ROP. To test this hypothesis, we measured development and recovery wild type Fzd4 heterozygous mice...