A5101815602- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- T-cell and B-cell Immunology
- Immune cells in cancer
- HIV/AIDS Research and Interventions
- Tuberculosis Research and Epidemiology
- CAR-T cell therapy research
- Tryptophan and brain disorders
- Healthcare Systems and Reforms
- Mental Health Research Topics
- Phagocytosis and Immune Regulation
- Immunotherapy and Immune Responses
- Mycobacterium research and diagnosis
- Global Health Care Issues
- Epigenetics and DNA Methylation
- Global Maternal and Child Health
- HIV-related health complications and treatments
- Complement system in diseases
- Chronic Disease Management Strategies
- Inflammasome and immune disorders
- Neurological Complications and Syndromes
- HIV, Drug Use, Sexual Risk
- Sexual Assault and Victimization Studies
- Grief, Bereavement, and Mental Health
- Single-cell and spatial transcriptomics
University of Electronic Science and Technology of China
2024-2025
Princess Margaret Cancer Centre
2019-2024
University Health Network
2019-2024
University of Toronto
2019-2024
Minzu University of China
2021
Communication University of China
2021
Zhejiang University
2018-2021
Nanjing Drum Tower Hospital
2021
Fudan University
2019
University of Minnesota
2018
The aryl hydrocarbon receptor (AhR) is a sensor of products tryptophan metabolism and potent modulator immunity. Here, we examined the impact AhR in tumor-associated macrophage (TAM) function pancreatic ductal adenocarcinoma (PDAC). TAMs exhibited high activity Ahr-deficient macrophages developed an inflammatory phenotype. Deletion Ahr myeloid cells or pharmacologic inhibition reduced PDAC growth, improved efficacy immune checkpoint blockade, increased intra-tumoral frequencies IFNγ+CD8+ T...
GCN2 is a key driver of Mϕ and MDSC polarization in the tumor microenvironment causing T cell exhaustion.
Flow cytometry is a widely applied approach for exploratory immune profiling and biomarker discovery in cancer other diseases. However, flow limited by the number of parameters that can be simultaneously analyzed, severely restricting its utility. Recently, advent mass (CyTOF) has enabled high dimensional unbiased examination system, allowing simultaneous interrogation large parameters. This important deep responses particularly when sample sizes are (such as tumors). Our goal was to compare...
<h3>Background</h3> Immune checkpoint inhibitors (ICIs) demonstrate unprecedented efficacy in multiple malignancies; however, the mechanisms of sensitivity and resistance are poorly understood predictive biomarkers scarce. INSPIRE is a phase 2 basket study to evaluate genomic immune landscapes peripheral blood tumors following pembrolizumab treatment. <h3>Methods</h3> Patients with incurable, locally advanced or metastatic solid that have progressed on standard therapy, for whom no therapy...
Multiple sclerosis is a severe autoimmune disorder that mainly mediated by pathogenic cluster of CD4+ T cell subsets. Despite advancements in the management multiple sclerosis, there critical need for more effective and safer treatments. In present study, we administered Lycium barbarum glycopeptide to mouse model experimental encephalomyelitis-an animal sclerosis-and evaluated its effects on activation both vivo vitro. significantly mitigated clinical severity encephalomyelitis, as...
This study aims to explore and visualize relationships among multiple psychological symptoms people living with HIV (PLWH) different HIV-positive durations compare centrality indices densities of symptom networks. We used subsets data collected from five designated HIV/AIDS hospitals in China. Networks were constructed 16 symptoms. Centrality properties, including strength closeness, adopted describe The results showed that PLWH longer had denser emotional networks, which indicated they more...
A lack of education among migrants remains an important but overlooked issue that indirectly contributes to HIV transmission. It is necessary know who has received and a lower probability being educated across different regions age groups in China. We used pooled data from the 2014 2015 Migrants Population Dynamic Monitoring Survey. The study population included 406,937 Chinese migrants. Participants were asked whether they had any after migrating destination city. Regions categorized into...
Access to HIV care has increased in China, but regional disparities for the unmet symptom management needs of people living with remain. Little attention been paid these disparities, especially rural areas. We describe 1,214 from five hospitals eastern coast, middle, and southern regions China. Insomnia, abnormal dreams, fatigue were most common patients urban whereas cognitive problems blurry vision Self-management capacity, discrimination, severity predicted more Medication adherence,...
CD4 T cells are central effectors of anti-cancer immunity and immunotherapy, yet the regulation tumor-specific (TTS) is unclear. We demonstrate that TTS quickly primed begin to divide following tumor initiation. However, unlike CD8 or exhaustion programming, cell proliferation rapidly frozen in place by a functional interplay regulatory CTLA4. Together these mechanisms paralyze differentiation, redirecting metabolic circuits, reducing their accumulation tumor. The paralyzed state actively...
Functional genomic screens in two-dimensional cell culture models are limited identifying therapeutic targets that influence the tumor microenvironment. By comparing targeted CRISPR-Cas9 a with xenografts derived from same line, we identified MEN1 as top hit confers differential dropout effects vitro and vivo. knockout multiple solid cancer types does not impact proliferation but significantly promotes or inhibits growth immunodeficient immunocompetent mice, respectively. Mechanistically,...
Middle-aged and older adults with HIV experience double discrimination cognitive impairment due to both their status age. However, the relationship between perceived self-reported ability in middle-aged people living (PLWH) is less clear. We measured using Expanded Everyday Discrimination Scale subscale of AIDS Health Assessment Questionnaire (AIDS-HAQ). The study sample included 324 PLWH (over 45 years old) from five designated hospitals three regions (east coast, middle, southwest regions)...
Many pathogens subvert intestinal immunity to persist within the gastrointestinal tract (GIT); yet, underlying mechanisms that enable sanctuary specifically in this reservoir are unclear. Using mass cytometry and network analysis, we demonstrate chronic LCMV infection of GIT leads dysregulated microbial composition, a cascade metabolic alterations, increased susceptibility GI disease, system-wide recalibration immune composition defines viral persistence. Chronic led outgrowth activated...
Chronic diseases have become serious threats to public health in China; the risk is particularly high for internal migrants. disease education a key prevention and control of chronic such population. The national population-based Migrants Population Dynamic Monitoring Survey (MPSMA) was used examine current status delivery methods among migrants, from both provincial level individual’s level. study population included 402 587 Multilevel logistic regression investigate factors that were...
Background: The quality of the dying experience among older adults should improve with a better understanding and its association place death in Mainland China. Objective: This study investigated relationship between Chinese context an urban-rural bifurcated system. Design: We used end-of-life module data from China Longitudinal Aging Social Survey conducted 2014 2016 eligible sample 352 decedents ages 60 older. Facial expression sadness at end life were indicators present study. performed...
Migrants are the key population for tuberculosis (TB) transmission in China. However, it remains unknown how many migrants have received TB education and through what means.To identify rate methods of among China by using nationally representative data.This study used secondary data analysis. The were derived from Dynamic Survey 2014-2017. A total sample 745,926 was included following Information on collected a self-report questionnaire. We hierarchical logistic regression models to explore...