A5102027896- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- MicroRNA in disease regulation
- Cancer-related gene regulation
- RNA Interference and Gene Delivery
- Phagocytosis and Immune Regulation
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Food composition and properties
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Neuroendocrine Tumor Research Advances
- Plant Surface Properties and Treatments
- Plant biochemistry and biosynthesis
- Cancer Genomics and Diagnostics
- RNA regulation and disease
- Lung Cancer Research Studies
- Histone Deacetylase Inhibitors Research
- HVDC Systems and Fault Protection
- ATP Synthase and ATPases Research
- Postharvest Quality and Shelf Life Management
- Galectins and Cancer Biology
- Genomics and Chromatin Dynamics
Princess Margaret Cancer Centre
2021-2025
University Health Network
2021-2025
Beijing Academy of Science and Technology
2024
Tobacco Research Institute
2024
China Tobacco
2024
Nantong University
2022
Zhongshan Hospital
2021
First Affiliated Hospital of Anhui Medical University
2021
Anhui Medical University
2021
Fudan University
2021
N6-methyladenosine (m6A) governs the fate of RNAs through m6A readers. Colorectal cancer (CRC) exhibits aberrant modifications and expression regulators. However, how readers interpret oncogenic methylome to promote malignant transformation remains be illustrated.YTH RNA binding protein 1 (Ythdf1) knockout mouse was generated determine effect Ythdf1 in CRC tumorigenesis vivo. Multiomic analysis RNA-sequencing, methylated immunoprecipitation sequencing, YTHDF1 proteomics were performed...
NSun2 is an RNA methyltransferase introducing 5-methylcytosine into tRNAs, mRNAs, and noncoding RNAs, thereby influencing the levels or function of these RNAs. Autotaxin (ATX) a secreted glycoprotein recognized as key factor in converting lysophosphatidylcholine lysophosphatidic acid (LPA). The ATX-LPA axis exerts multiple biological effects cell survival, migration, proliferation, differentiation. Here, we show that involved regulation migration through methylating ATX mRNA. In human glioma...
Abstract MYC is a well characterized oncogenic transcription factor in prostate cancer, and CTCF the main architectural protein of three-dimensional genome organization. However, functional link between two master regulators has not been reported. In this study, we find that rewires cancer chromatin architecture by interacting with protein. Through combining H3K27ac, AR HiChIP profiles CRISPR deletion site upstream gene, show activation leads to profound changes CTCF-mediated looping....
N6-methyladenosine (m6A), the most abundant internal RNA modification in humans, regulates aspects of processing. Prostate cancer is characterized by widespread transcriptomic dysregulation; therefore, we m6A landscape 162 localized prostate tumors with matched DNA, and protein profiling. abundance varied dramatically across tumors, global patterns emerging via complex germline–somatic cooperative regulation. Individual germline polymorphisms regulated abundance, cooperating somatic mutation...
The basic helix-loop-helix (bHLH) gene family has been identified in many species. However, the characteristics and functions Magnolia sieboldii K. Koch (M. sieboldii), which is located one of original groups angiosperms, are still unclear. Here, a total 142 MsbHLH members were divided into 27 subfamilies. proteins relatively conserved during evolution. Collinearity analysis illustrated that expansion primarily occurred through segmental duplication. All contain light-responsive elements...
Huntingtin protein, mutated in Huntington’s disease, is implicated nucleic acid–mediated processes, yet the evidence for direct huntingtin–nucleic acid interaction limited. Here, we show wild-type and mutant huntingtin copurify with acids, primarily RNA, interact directly G-rich RNAs vitro assays. RNA-immunoprecipitation sequencing from patient-derived fibroblasts neuronal progenitor cells expressing revealed long noncoding RNA NEAT1 as a significantly enriched transcript. Altered levels...
S100 protein family members (S100s) are commonly dysregulated in various tumors including hepatocellular carcinoma (HCC). However, the diverse expression, mutation, prognosis and associations with immune infiltration of S100s HCC have yet to be analyzed. Herein we investigated roles from Oncomine, Gene Expression Profiling Interactive Analysis (GEPIA), Human Protein Atlas, Kaplan-Meier Plotter, cBioPortal TIMER databases. Compared para-cancer tissues, expression levels...
Gastric cancer presents high risk of metastasis and chemotherapy resistance. Hence, it is important to understand the mechanisms gastric distant chemotherapeutic Our previous study has revealed Four a Half LIM Domains 3 (FHL3) plays as binding partner Glycogen Synthase Kinase Beta (GSK3β), promoted tumor in pancreatic cancer. However, role FHL3 still remains unclear.TCGA database clinical samples are used for exploring disease progression prognosis. Oxaliplatin (OHP) resistance cell lines...
The aboveground parts of plants are covered with cuticle, a hydrophobic layer composed cutin polyester and cuticular wax that can protect from various environmental stresses. β -Ketoacyl-CoA synthase (KCS) is the key rate-limiting enzyme in plant synthesis. Although properties KCS family genes have been investigated many species, understanding this gene sorghum still limited. Here, total 25 SbKCS were identified genome, which named SbKCS1 to SbKCS25 . Evolutionary analysis among different...
// Li Tang 1 , Xue-Mei Yi Jia Chen 2 Fu-Juan Wei Lou Yun-Lu Gao Jing Zhou Li-Na Su Xin Xu Jia-Qing Lu Jun Ma Ning Yu Yang-Feng Ding Department of Dermatology, Shanghai Skin Disease Hospital, Shanghai, P. R. China Pathology, Correspondence to: Yang-Feng, Ding, e-mail: dingyangfeng@hotmail.com Keywords: melanoma, invasion and metastasis, ubiquitin ligase, UBE3C Received: July 24, 2015 Accepted: January 13, 2016 Published: February 15, ABSTRACT Melanoma is the most aggressive type skin cancer,...
Abstract Comprehensive N6-methyladenosine (m6A) epitranscriptomic profiling of primary tumors remains largely uncharted. Here, we profiled the m6A epitranscriptome 10 nonneoplastic lung tissues and 51 adenocarcinoma (LUAD) tumors, integrating corresponding transcriptomic, proteomic, extensive clinical annotations. We identified distinct clusters genes that were exclusively linked to disease progression through modifications. In comparison with tissues, 430 transcripts be hypo-methylated 222...
Functional genomic screens in two-dimensional cell culture models are limited identifying therapeutic targets that influence the tumor microenvironment. By comparing targeted CRISPR-Cas9 a with xenografts derived from same line, we identified MEN1 as top hit confers differential dropout effects vitro and vivo. knockout multiple solid cancer types does not impact proliferation but significantly promotes or inhibits growth immunodeficient immunocompetent mice, respectively. Mechanistically,...
Abstract Non-coding RNA (ncRNA) and binding proteins (RBPs) primarily reside in the nucleus to regulate splicing, transcription, transcript stability. However, their role(s) cytoplasm were unclear until now. Evidence now suggests that ncRNAs within play an important role cancer invasion. In concert with MT1-MMP, a protease involved invadopodia formation, long non-coding RNAs (lncRNAs) RBPs form cytoplasmic complexes which we termed “R-bodies” are abundant invasive breast cells....
<div>Abstract<p>Comprehensive N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) epitranscriptomic profiling of primary tumors remains largely uncharted. Here, we profiled the m<sup>6</sup>A epitranscriptome 10 nonneoplastic lung tissues and 51 adenocarcinoma (LUAD) tumors, integrating corresponding transcriptomic, proteomic, extensive clinical annotations. We identified distinct clusters genes that were exclusively linked to disease progression...
<p>Association of m6A with clinical features and patient survival.</p>
<p>Analysis of EML4 and METTL3 protein levels in LUAD patient tumors functional assays perturbation.</p>
<p>mRNA abundance of m6A regulators in lung tissues and genomic characteristics G1, G2 G3 gene groups.</p>
<p>Toxicity assessment of STM2457 treatment.</p>
<p>The function of BLVRA m6A.</p>