A5077429502- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- Inflammatory Bowel Disease
- Gut microbiota and health
- Ferroptosis and cancer prognosis
- Medicinal Plants and Bioactive Compounds
- Liver Disease and Transplantation
- Vacuum and Plasma Arcs
- Metabolism, Diabetes, and Cancer
- Probiotics and Fermented Foods
- Renal cell carcinoma treatment
- Venous Thromboembolism Diagnosis and Management
- Parasitic Infections and Diagnostics
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Glaucoma and retinal disorders
- Biological and pharmacological studies of plants
- Cancer Mechanisms and Therapy
- Electrical Fault Detection and Protection
- Morinda citrifolia extract uses
- NF-κB Signaling Pathways
- Frequency Control in Power Systems
- Gout, Hyperuricemia, Uric Acid
- Curcumin's Biomedical Applications
- PI3K/AKT/mTOR signaling in cancer
Zhongshan Hospital of Xiamen University
2021-2025
Fudan University
2021-2025
Yantaishan Hospital
2016-2025
Xi'an Jiaotong University
2008-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
1998-2024
Peking Union Medical College Hospital
1998-2024
State Key Laboratory of Electrical Insulation and Power Equipment
2024
First Affiliated Hospital of Nanchang University
2017-2023
Nanchang University
2017-2023
Chinese PLA General Hospital
2021-2023
Summary This was a pilot study aiming to evaluate the effects of probiotics as adjunctive treatment for ulcerative colitis (UC). Twenty‐five active patients with UC were assigned probiotic ( n = 12) and placebo 13) groups. The group received mesalazine (60 mg kg −1 day ) oral (containing Lactobacillus casei Zhang, plantarum P‐8 Bifidobacterium animalis subsp . lactis V9) twice daily 12 weeks, while same amounts placebo. clinical outcomes assessed. gut mucosal microbiota profiled by PacBio...
Objective This study was aimed at ascertaining the application value of abnormal prothrombin (PIVKA-II) and carbohydrate antigen 125 (CA125) in gallbladder cancer (GBC) diagnosis. Methods A total 70 GBC patients, patients with benign diseases (gallbladder stones polyps), normal health examination people were selected as malignant, benign, groups, respectively. The differences serum levels positive rates PIVKA-II CA125 compared. correlation between different clinicopathological...
Background: The combination of nivolumab and ipilimumab has demonstrated significant antitumor activity in first-line treatment for hepatocellular carcinoma (HCC) second-line following progression on sorafenib. However, the efficacy safety plus anti-PD-1/PD-L1 antibodies therapy advanced HCC patients who have progressed after multiple lines not yet been reported. Materials Methods: We conducted a multicenter retrospective study that included 33 had immune-targeted received therapy. All at...
Morinda officinalis is beneficial for the treatment of inflammatory bowel disease (IBD). The hairy root with higher genetic and biochemical stability cultured from M. might have similar effects to treat IBD. In this study, main chemical composition extracts (MORE) native plant extract (MOHRE) was compared by quantitative HPLC. difference their therapeutic potential mechanism evaluated using 3% dextran sodium sulfate-induced chronic colitis in mice T lymphocytes vitro. results found that...
Recent studies have shown an indirect link between platelet count and blood vessel metastasis, but this association with lymphatic vessels metastasis has not been established in NSCLC.So we investigated whether exists preoperative lymph node NSCLC patients.Between January 2001 2011, counts were obtained from 883 patients who resistant to chemotherapy, radiotherapy, surgery.The counts, tumor overall survival of analyzed for correlations via statistical analysis.Upon considering according...
S100 protein family members (S100s) are commonly dysregulated in various tumors including hepatocellular carcinoma (HCC). However, the diverse expression, mutation, prognosis and associations with immune infiltration of S100s HCC have yet to be analyzed. Herein we investigated roles from Oncomine, Gene Expression Profiling Interactive Analysis (GEPIA), Human Protein Atlas, Kaplan-Meier Plotter, cBioPortal TIMER databases. Compared para-cancer tissues, expression levels...
Pyroptosis is a novel kind of cellular necrosis and shown to be involved in cancer progression. However, the diverse expression, prognosis associations with immune status pyroptosis-related genes Hepatocellular carcinoma (HCC) have yet analyzed. Herein, expression profiles corresponding clinical characteristics HCC samples were collected from Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) databases. Then gene signature was built by applying least absolute shrinkage selection...
To explore the therapeutic effect of curcumin (Cur) and soybean oligosaccharides (SBOS) on ulcerative colitis (UC) through testing intestinal flora (UC). 80 male SD rats were selected divided into four groups with 20 in each group: normal group, sulfasalazine (SASP) model group plus soy oligosaccharide. All animals treated for 4 weeks. In fifth week decapitated. Macroscopic damage scores colonic mucosa calculated. A 4mL blood sample was taken to detect contents serum tumor necrosis factor...
To investigate the relationship between ARID1A expression and clinicopathologic parameters, as well its prognostic value, for patients with intrahepatic cholangiocarcinoma (IHCC).We assessed protein mRNA in IHCC tissues paracarcinomatous (PC) from 57 using western blot quantitative real-time reverse transcription polymerase chain reaction, respectively. We used Fisher's exact χ(2) tests to analyze relationships clinicopathological parameters expression. The Kaplan-Meier method Cox regression...
PU box binding protein (PU.1) is a critical transcription factor involved in many pathological processes. However, its exact role activation of hepatic stellate cells (HSCs) and liver fibrosis was rarely reported. Here, we found that, HSCs PU.1+/- mice, Sirt1 mRNA expression not changed but significantly increased, suggesting promoting translation. We then isolated from wild-type (WT) the pcDNA-PU.1 vector transfected into HSCs. checked levels miR-34a miR-29c, two Sirt1-targetting miRNAs,...
Patients with type 2 diabetes mellitus (T2DM) often have cognitive impairment and structural brain abnormalities. The magnetic resonance imaging (MRI)-based atrophy lesion index can be used to evaluate common changes their correlation function, therefore also reflect whole-brain related T2DM. A total of 136 participants (64 men 72 women, aged 55-86 years) were recruited for our study between January 2014 December 2016. All underwent MRI Mini-Mental State Examination assessment (including 42...
Myeloid cells are physiologically related to innate immunity and inflammation. Tumor-associated myeloid gained increasing interest because of their critical roles in tumor progression anticancer immune responses human malignancies. However, the associations between tumor-associated cell-related genes hepatocellular carcinoma have yet be revealed. Here, through integrating analysis bulk single-cell RNA (scRNA) sequencing public HCC samples, we developed a gene signature investigate role...
This paper focuses on the numerical and experimental investigations of influence two polymers (PA6 POM) arc behavior during motion process. The mathematical model 3-dimentional air plasma considering ablation lateral walls is built based magnetic hydro-dynamics (MHD). By adopting commercial computational fluid dynamics (CFD) package control-volume method, above MHD solved distribution temperature field, concentration flow field electrical potential in chamber are calculated. simulation...
Drug interactions are one of the commonest causes side effects, particularly in long-term therapy. The aim current study was to investigate possible effects metoprolol on pharmacokinetics metformin rats and clarify mechanism drug interaction. In this study, were treated with alone or combination metoprolol. Plasma, urine tissue concentrations determined by HPLC. Western blotting real-time qPCR used evaluate expression rOCTs rMATE1. results showed that, after single 7-day repeated...
Abstract The kidney plays a major part in the elimination of many drugs and their metabolites, drug‐induced injury commonly alters either glomerular filtration or tubular transport, both. However, renal excretion pathway has not been fully elucidated at different stages injury. This study aimed to evaluate alteration pathways gentamicin (GEN)‐induced rats. Results showed that serum cystatin C, creatinine urea nitrogen levels were greatly increased by exposure GEN (100 mg kg –1 ),...
Background and Objectives: To assess the efficacy safety of hepatic arterial infusion chemotherapy (HAIC) with oxaliplatin plus raltitrexed (HAICROX) as an alternative treatment option for advanced hepatocellular carcinoma (HCC) patients who are ineligible for, or failed, transarterial chemoembolization (TACE) treatment. Materials Methods: From July 2020 to November 2021, a total 35 HCC were enrolled received HAIC raltitrexed. The overall survival (OS) time progression (TTP) primary...
To study the index system of enhanced recovery after surgery (ERAS) nursing evaluation, as a basis for quality evaluation hepatobiliary care, continue to improve care.The 300 cases surgical diseases treated in our hospital from January 2019 December 2020 were randomly selected subjects this study. Through clinical trials, two groups used, one ERAS care group and traditional group. questionnaire survey access relevant research data, statistical data analysis was performed using SPSS 22.0...
A new type of algorithm for predicting the mechanical faults a vacuum circuit breaker (VCB) based on an artificial neural network (ANN) is proposed in this paper. There are two types VCB: operation mechanism and tripping faults. An angle displacement sensor used to measure main axle which reflects moving contact, obtain state VCB, while Hall current trip coil current, circuit. Then ANN prediction sliding time window paper successfully predict VCB. The research results provide theoretical...