Hongbing Liu
A5106382325- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Treatments and Studies
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- HER2/EGFR in Cancer Research
- Gastric Cancer Management and Outcomes
- Neuroendocrine Tumor Research Advances
- Pleural and Pulmonary Diseases
- Winter Sports Injuries and Performance
- Cancer Cells and Metastasis
- Occupational and environmental lung diseases
- Cancer-related molecular mechanisms research
- Asthma and respiratory diseases
- Peptidase Inhibition and Analysis
- Tracheal and airway disorders
- Quinazolinone synthesis and applications
- Cancer, Stress, Anesthesia, and Immune Response
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Head and Neck Cancer Studies
- Melanoma and MAPK Pathways
- Congenital Diaphragmatic Hernia Studies
Southeast University
2019-2024
Nanjing General Hospital of Nanjing Military Command
2012-2024
Nanjing University
2013-2024
Nanjing Medical University
2019-2024
Nanchang University
2013-2024
Linzhou Cancer Hospital
2024
Second Affiliated Hospital of Nanchang University
2013-2024
Shenyang Pharmaceutical University
2023
Tulane University
2023
Zigong First People's Hospital
2023
Background: Changes in metabolism have been suggested to contribute the aberrant phenotype of vascular wall cells, including fibroblasts, pulmonary hypertension (PH). Here, we test hypothesis that metabolic reprogramming aerobic glycolysis is a critical adaptation fibroblasts hypertensive vessel drives proliferative and proinflammatory activation through mechanism involving increased activity NADH-sensitive transcriptional corepressor C-terminal binding protein 1 (CtBP1). Methods: RNA...
Abstract Interactions of tumor cells with immune in the microenvironment play an important role during malignancy progression. We previously identified that GAS5 inhibited development by suppressing proliferation non-small cell lung cancer (NSCLC). Herein, we discovered a tumor-suppressing for cell-derived regulating microenvironment. positively coordinated infiltration macrophages and T NSCLC clinically, overexpression promoted recruitment both vitro vivo. Mechanistically, stabilized p53...
Abstract Background We indirectly compared the effects of immune checkpoint inhibitors alone (ICI) and ICI-combined chemotherapy (chemo-ICI) in patients with non-small cell lung cancer who had high programmed death-ligand 1 (PD-L1) expression (defined as tumour proportion score ≥50% or TC3/IC3) through network meta-analyses. Methods Through literature searches, we shortlisted 22 randomised controlled trials encompassing 4289 patients, objective response rate (ORR), progression-free survival...
Thymic epithelial tumors (TETs) are a relatively rare type of thoracic tumor, accounting for less than 1% all tumors. The incidence TETs is about 3.93/10000 in China, slightly higher that European and American countries. For resectable TETs, complete surgical resection recommended. Radiotherapy or chemotherapy may be used as postoperative adjuvant treatment. Treatment advanced, unresectable consist mainly radiotherapy chemotherapy, but there lack standard first- second-line treatment...
Schizophrenia (SCZ) is a prevalent and serious mental disorder, the exact pathophysiology of this condition not fully understood. In previous studies, it has been proven that ferroprotein levels are high in SCZ. It also shown inflammatory response may modify fibromodulin. Accumulating evidence indicates strong link between metabolism ferroptosis. Therefore, present study aims to identify ferroptosis-linked hub genes further investigate role ferroptosis plays development
Background The efficacy of adjuvant chemotherapy in patients with 8th edition stage IB (tumor size ≤4 cm) non-small cell lung cancer (NSCLC) remains unclear. Methods We identified 9757 eligible (non-chemotherapy group: n=8303; n=1454) between 2004 and 2016 from the Surveillance, Epidemiology End Results (SEER) database. Log-rank test was used to compare overall survival (OS) non-chemotherapy groups. Cox regression model applied investigate independent prognosis factors all surgically treated...
Abstract Antibody–drug conjugates (ADCs) have demonstrated effectiveness in treating various cancers, particularly exhibiting specificity targeting human epidermal growth factor receptor 2 (HER2)‐positive breast cancer. Recent advancements phase 3 clinical trials broadened current understanding of ADCs, especially trastuzumab deruxtecan, other HER2‐expressing malignancies. This expansion knowledge has led to the US Food and Drug Administration's approval deruxtecan for HER2‐positive HER2‐low...
Several randomized controlled trials (RCTs) indicated that first-line programmed cell death protein-1/death-ligand 1 inhibitors plus chemotherapy (PD-1/PD-L1 + chemo) led to survival benefits in extensive-stage small-cell lung cancer (ES-SCLC) compared with platinum-based chemotherapy. This study aims identify the optimal PD-1/PD-L1 chemo combination strategy.We included RCTs comparing PD-1/ PD-L1 versus alone ES-SCLC. Overall (OS), progression-free (PFS), objective response rate (ORR), and...
Abstract The fusion genes NRG1 and NRG2, members of the epidermal growth factor (EGF) receptor family, have emerged as key drivers in cancer. Upon fusion, retains its EGF-like active domain, binds to ERBB ligand triggers intracellular signaling cascades, promoting uncontrolled cell proliferation. incidence gene varies across cancer types, with lung being most prevalent at 0.19 0.27%. CD74 SLC3A2 are frequently observed partners. RNA-based next-generation sequencing is primary method for...
Spread through air spaces (STAS) is one of the multiple modes lung cancer dissemination, yet its molecular and clinicopathological characterization remains poorly studied. This study aimed to investigate effect adhesion molecule expression levels on incidence STAS postoperative recurrence in stage I patients undergoing radical resection.
Defects on the surface of steel strips are main factors to evaluate quality strips, inspection is great importance improve strips. Traditional by human inspectors far from satisfactory. In this paper, an approach detect defects based feed-forward neural network (FFN) discussed. The experiments show that method effective.
Recent studies have shown an indirect link between platelet count and blood vessel metastasis, but this association with lymphatic vessels metastasis has not been established in NSCLC.So we investigated whether exists preoperative lymph node NSCLC patients.Between January 2001 2011, counts were obtained from 883 patients who resistant to chemotherapy, radiotherapy, surgery.The counts, tumor overall survival of analyzed for correlations via statistical analysis.Upon considering according...
There is no standard care for advanced non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutation in the third line. Our study aimed to assess efficacy and safety of gefitinib as a third-line re-challenge treatment NSCLC EGFR mutation.It was multicenter, open-label, single-arm, phase II study. Stage IIIB/IV exon 19del/L858R mutation, who had benefited from first-line followed by second-line chemotherapy, received 250 mg/d. The primary objective disease...
Malignant pleural mesothelioma (MPM) is a malignant tumor originating from the pleura, and its incidence has been increasing in recent years. Due to insidious onset strong local invasiveness of MPM, most patients are diagnosed late stage early screening treatment for high-risk populations crucial. The MPM mainly includes surgery, chemotherapy, radiotherapy. Immunotherapy electric field therapy have also applied, leading further improvements patient survival. Mesothelioma Group Yangtze River...
The rearranged during transfection (RET) gene is one of the receptor tyrosine kinases and cell-surface molecules responsible for transmitting signals that regulate cell growth differentiation. In non-small lung cancer (NSCLC), RET fusion a rare driver alteration associated with poor prognosis. Fortunately, two selective inhibitors (sRETi), namely pralsetinib selpercatinib, have been approved treating NSCLC due to their remarkable efficacy safety profiles. These shown ability overcome...
Background and objectives: The voice quality assessment of laser surgery (LS) in comparison with radiotherapy (RT) remains uncertain T1a glottic carcinoma treatment. This systematic review meta-analysis were conducted to compare the two treatments. Methods: Searches PubMed, EMBASE, Cochrane following index words: glotti*, layn*, vocal cord, vocal, surgery, cordectomy, laser, radiation, irradiation, radiotherapy, cancer, for relative studies that compared between LS RT. Random-effect models...
Background The relationship between epidermal growth factor receptor ( EGFR) gene mutation status, preoperative computed tomography CT), and clinical features in patients with small peripheral lung adenocarcinoma (<3 cm) was investigated. Methods We included 209 who underwent surgical resection for stage I or II at N anjing General Hospital D ecember 2010 M ay 2016. 171 cases of a pretreatment chest CT. Eleven different CT descriptors were assessed. Multiple logistic regression analyses...
Abstract Human epidermal growth factor receptor 2 (HER2) possesses tyrosine kinase activity and participates in cell growth, differentiation migration, survival. Its alterations, mainly including mutations, amplifications, overexpression are associated with poor prognosis one of the major drivers non–small lung cancer (NSCLC). Several clinical trials had been investigating on treatments HER2‐altered NSCLC, conventional chemotherapy, programmed death 1 (PD‐1) inhibitors, inhibitors (TKIs)...
Recent studies demonstrate that PLK4 has emerged as a therapeutic target for the treatment of multiple cancers owing to its indispensable role in cell division. Herein, starting from previously identified effective compound CZS-034, based on rational drug design strategies, tyrosine kinase receptor A (TRKA) selectivity- and metabolic stability-guided structure-activity relationship (SAR) exploration were carried out discover highly potent (IC50 = 2.6 nM) selective (SF 1054.4 over TRKA)...