A5101756384- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Computational Drug Discovery Methods
- Pleural and Pulmonary Diseases
- Lung Cancer Research Studies
- Medical Imaging and Pathology Studies
- Radiomics and Machine Learning in Medical Imaging
- Climate Change and Health Impacts
- Neuroendocrine Tumor Research Advances
- Hepatocellular Carcinoma Treatment and Prognosis
- Air Quality and Health Impacts
- Extracellular vesicles in disease
- Peptidase Inhibition and Analysis
- Ferroptosis and cancer prognosis
- Soil Carbon and Nitrogen Dynamics
- Esophageal Cancer Research and Treatment
- Melanoma and MAPK Pathways
- Myasthenia Gravis and Thymoma
- Noise Effects and Management
- Genetic factors in colorectal cancer
- Gastric Cancer Management and Outcomes
- Neonatal Respiratory Health Research
Guangdong Provincial People's Hospital
2019-2025
Guangdong Academy of Medical Sciences
2017-2025
Southern Medical University
2017-2025
Sun Yat-sen University
2025
Sun Yat-sen University Cancer Center
2025
Harbin Medical University
2025
Third Affiliated Hospital of Harbin Medical University
2025
Nanfang Hospital
2024-2025
Betta Pharmaceuticals (China)
2025
Lu'an First People's Hospital
2024
Patients with EGFR mutations showed unfavorable response to programmed cell death-1 (PD-1) blockade immunotherapy in non-small lung cancer (NSCLC). Yet the underlying association between mutation and immune resistance remains largely unclear. We performed an integrated analysis of PD-ligand 1(PD-L1)/CD8 expression profile based on repository database resected early-stage NSCLC Guangdong Lung Cancer Institute (GLCI). Meanwhile, 2 pool-analyses were set clarify correlation PD-L1 expression,...
The efficacy and potential limitations of molecular residual disease (MRD) detection urgently need to be fully elucidated in a larger population non-small cell lung cancer (NSCLC). We enrolled 261 patients with stages I III NSCLC who underwent definitive surgery, 913 peripheral blood samples were successfully detected by MRD assay. Within the population, only six (3.2%) longitudinal undetectable recurred, resulting negative predictive value 96.8%. Longitudinal may define cured. peak risk...
Diabetic wounds has a gradually increasing incidence and morbidity. Excessive inflammation due to immune imbalance leads delayed wound healing. Here, we reveal the interconnection between activation of NLRP3 inflammatory pathway in endotheliocyte polarization macrophages via cGAS-STING oxidative microenvironment. To enhance immune-regulation based on repairing mitochondrial damage, zeolitic imidazolate framework-8 coated with cerium dioxide that carries Rhoassociated protein kinase...
Importance Uninterrupted targeted therapy until disease progression or intolerable toxic effects is currently the routine for advanced non−small cell lung cancer (NSCLC) involving driver gene variations. However, drug resistance inevitable. Objective To assess clinical feasibility of adaptive de-escalation tyrosine kinase inhibitor (TKI) treatment guided by circulating tumor DNA (ctDNA) achieving complete remission after local consolidative (LCT) in patients with NSCLC. Design, Setting, and...
Abstract Drought and nitrogen enrichment could profoundly affect the productivity of semiarid ecosystems. However, how ecosystem will respond to different drought scenarios, especially with a concurrent increase in availability, is still poorly understood. Using data from 4‐year field experiment conducted temperate steppe, we explored responses aboveground net primary (ANPP) scenarios addition, underlying mechanisms linking soil properties, plant species richness, functional diversity...
Background Patient‐derived organoid (PDO) models are highly valuable and have potentially widespread clinical applications. However, limited information is available regarding of non‐small cell lung cancer (NSCLC). This study aimed to characterize the consistency between primary tumors in NSCLC PDOs explore applications as preclinical understand predict treatment response during cancer. Methods Fresh tumor samples were harvested for culture. Primary analyzed via whole‐exome sequencing....
MET amplification plays an important role in the development of non-small-cell lung cancer (NSCLC) either de novo or resistance to epidermal growth factor receptor tyrosine-kinase inhibitor (EGFR-TKI) settings. Fluorescence situ hybridization (FISH) is standard method for amplification. With more and discoveries oncogenic driver genes, next-generation sequencing (NGS) a significant precision oncology. Meanwhile, NGS remains uncertain.Forty patients diagnosed with advanced NSCLC were...
Thymic epithelial tumors (TETs) are a relatively rare type of thoracic tumor, accounting for less than 1% all tumors. The incidence TETs is about 3.93/10000 in China, slightly higher that European and American countries. For resectable TETs, complete surgical resection recommended. Radiotherapy or chemotherapy may be used as postoperative adjuvant treatment. Treatment advanced, unresectable consist mainly radiotherapy chemotherapy, but there lack standard first- second-line treatment...
PdCl2(PPh3)2 in a mixture of water and poly(ethylene glycol) (PEG-2000) is shown to be an extremely active catalyst for the carbonylative Sonogashira coupling reaction aryl iodides with terminal alkynes. The can conducted under atmospheric pressure carbon monoxide at 25 °C Et3N as base, yielding variety alkynyl ketones good excellent yields. Application this synthetic method prepare flavones from o-iodophenol alkynes was also achieved. isolation products readily achieved by extraction...
In this study, we evaluated the diagnostic value and molecular characteristics of plasma extracellular vesicles (EVs)-derived miRNAs for patients with solitary pulmonary nodules (SPNs), particularly ground-glass (GGNs). This study was registered at www.clinicaltrials.gov under registration number NCT03230019. Small RNA sequencing performed to assess EVs in 59 patients, including 12 benign (2017, training set). MiRNA profiles 40 an additional individuals were sequenced (2018, validation...
The 2015 World Health Organization classification defines pulmonary large-cell neuroendocrine carcinoma (LCNEC) as a high-grade carcinoma. However, the clinical characteristics and prognostic factors of pure LCNEC combined remain unclear. Hence, we performed multi-center retrospective study to compare outcomes versus LCNEC.Data from 381 patients with admitted 17 Chinese institutes between 2009 2016 were collected retrospectively. Clinical prognosis analyzed among receiving adjuvant (adjuvant...
Enzyme activity plays an important role in soil biochemical processes and is a key factor driving nutrient cycling. Although great number of studies examined the effects nitrogen (N) enrichment water (W) addition on enzyme activity, most them focused effect only one resource are based short-term investigations. The separate interactive long-term changes remain largely unexplored. In this study, we demonstrated responses two types enzyme, β-1,4-glucosidase (BG) acid phosphatase (APA), to...
Circulating tumor DNA (ctDNA) has potential as a promising biomarker for molecular residual disease (MRD) detection in lung cancer. As the next‐generation sequencing standardized panel ctDNA emerges, its clinical utility needs to be validated. We prospectively recruited 184 resectable cancer patients from four medical centers. Serial postoperative ctDNAs were analyzed by panel. A total of 427 plasma samples 177 eligible enrolled. positivity after surgery was an independent predictor...
Constrained by no proper way to assess cumulative exposure, the joint effect of air pollution exposure doses on childhood asthma and wheezing (AW) was not understood.
The identification of indeterminate pulmonary nodules (IPNs) following a low-dose computed tomography (LDCT) is major challenge for early diagnosis lung cancer. inadequate assessment IPNs' malignancy risk results in large number unnecessary surgeries or an increased cancer metastases. However, limited studies on non-invasive IPNs have been reported.In this study, we identified and evaluated the diagnostic value circulating small extracellular vesicle (sEV) microRNAs (miRNAs) patients with...
Background: Intracerebral hemorrhage (ICH) is a leading cause of disability and mortality, accounting for 20-30% acute cerebrovascular events. Resting heart rate (RHR) an important vital sign linked to prognosis, particularly in cardiovascular diseases. This study investigates the association between RHR all-cause mortality (ACM) intensive care unit (ICU) patients with ICH. Methods: Data were extracted from MIMIC-IV database. Patients divided into quartiles (Q1?Q4) based on RHR. ACM at 30...
Abstract Purpose: The prognostic value of molecular residual disease (MRD) in non-small cell lung cancer (NSCLC) is well-established, with treatment-guiding results anticipated. Here, we present updated analyses from our previous published cohort study 261 NSCLC patients undergoing complete resection. Experimental Design: stage I-III who underwent radical surgery were enrolled. Enrolled follow-up blood draws according to the predefined time points after surgery. As December 31st, 2023, a...
We introduce Baichuan-Omni-1.5, an omni-modal model that not only has understanding capabilities but also provides end-to-end audio generation capabilities. To achieve fluent and high-quality interaction across modalities without compromising the of any modality, we prioritized optimizing three key aspects. First, establish a comprehensive data cleaning synthesis pipeline for multimodal data, obtaining about 500B (text, audio, vision). Second, audio-tokenizer (Baichuan-Audio-Tokenizer) been...
Abstract Background Patients with intermediate stage hepatocellular carcinoma (HCC) require repeated disease monitoring, prognosis assessment and treatment planning. A novel machine learning model called survival path mapping (SP) was developed, while its performance as compared conventional models remains unknown. Methods Between January 2007 Dec 2018, the time-series data of 2644 HCC patients from four medical centers in China were reviewed included. Static by Gaussian Naive Bayes (GNB),...
Abstract Anti‐PD‐1 immunotherapy and targeted therapy (TT) represent two major therapeutic modalities for BRAF V600 ‐mutant advanced melanoma, but the efficacy of combination in Asian populations remains unknown. melanoma patients differ significantly from Caucasians tissue subtypes, pathogenesis response to treatment. We retrospectively analyzed data treated with first‐line vemurafenib (V) ± anti‐PD‐1 or dabrafenib+trametinib (D+T) between 2014 2023 three centers China. 178 were included, V...