A5108779162- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Molecular Biology Techniques and Applications
- COVID-19 and healthcare impacts
- Mycobacterium research and diagnosis
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Neuroendocrine Tumor Research Advances
- Hepatitis B Virus Studies
- Reproductive System and Pregnancy
- Energy Load and Power Forecasting
- IgG4-Related and Inflammatory Diseases
- Electric Power System Optimization
- Nanoparticle-Based Drug Delivery
- COVID-19 Clinical Research Studies
- Nanoplatforms for cancer theranostics
- Power System Optimization and Stability
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Extracellular vesicles in disease
Southern Medical University
2020-2025
Guangdong Provincial People's Hospital
2023-2025
Guangdong Academy of Medical Sciences
2023-2025
South China University of Technology
2023-2025
Nanfang Hospital
2020-2023
Guangxi Medical University
2020-2023
First Affiliated Hospital of GuangXi Medical University
2020-2022
Nanchang University
2019-2021
Guizhou Electric Power Design and Research Institute
2021
Second Affiliated Hospital of Nanchang University
2019-2021
Abstract Background Metabolic reprogramming is a hallmark of cancer. However, the roles long noncoding RNAs (lncRNAs) in cancer metabolism, especially glucose metabolism remain largely unknown. Results In this study, we identified and functionally characterized novel metabolism-related lncRNA, LINC00930, which was upregulated associated with tumorigenesis, lymphatic invasion, metastasis, poor prognosis nasopharyngeal carcinoma (NPC). Functionally, LINC00930 required for increased glycolysis...
: Previous studies of coronavirus disease 2019 (COVID-19) were mainly focused on cross-sectional analysis. In this study, we sought to evaluate the dynamic changes immunological and radiographic features, association with outcome pulmonary lesions in COVID-19 patients.
It has been reported that atractylodin a potential antitumor effect. This study aimed to investigate the effects of on Huh7 and Hccm hepatocellular carcinoma (HCC) cells its molecular mechanism.Huh7 were cultured in vitro, their viability was detected by CCK-8 assay half inhibitory concentration (IC50) calculated. The treated with different concentrations atractylodin, migration invasion ability scratch Transwell assay. cell cycle change apoptosis rate flow cytometry. IlluminaHiSeq4000...
Background and Aims: Long-term maintenance of viral control, even HBsAg loss, remains a challenge for chronic hepatitis B (CHB) patients undergoing nucleos(t)ide analogue (NA) discontinuation. This study aimed to investigate the relationship between HBV-specific T cell responses targeting peptides spanning whole proteome clinical outcomes in CHB after NA Approach Results: Eighty-eight discontinuation were classified as responders (remained relapse-free up 96 wk) or relapsers (relapsed who...
Abstract Background The effects of gut microbiota and metabolites on the responses to immune checkpoint inhibitors (ICIs) in advanced epidermal growth factor receptor (EGFR) wild-type non-small cell lung cancer (NSCLC) have been studied. However, their EGFR -mutated (EGFR + ) NSCLC remain unknown. Methods We prospectively recorded clinicopathological characteristics patients with assessed potential associations between use antibiotics or probiotics immunotherapy efficacy. Fecal samples were...
Targeted therapy has dramatically altered the treatment paradigm for some patients with inflammatory myofibroblastic tumor (IMT) that possesses specific molecular aberrations. IMT is an exceedingly rare type of sarcoma, about 50% cases featuring anaplastic lymphoma kinase (ALK) gene rearrangements. The ALK fusions using tyrosine inhibitors (TKIs) become increasingly common. However, until now, there a lack evidence supporting efficacy third-generation ALK-TKIs in this disease category. Here,...
Summary With the rapid development of Internet Things (IoT), fog computing has emerged as a complementary solution to address issues faced in cloud computing. However, it is challenging issue ensure both high Quality Service (QoS) and low cost for different requests when dealing with resources. In this article, we propose new approach on adaptive cost‐efficient QoS‐aware application placement called DATSS. Specifically, consists QoS state driven strategy credibility rating mechanism. The...
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: COVID-19 has been ravaging the globe for more than three years. Due to systemic immunosuppression of anti-tumor therapy, application chemotherapy and adverse effects surgery, short- long-term prognosis cancer patients are significant concern.
Introduction: This study implies the enhancement of apatinib killing effect in 4T1 tumor cells through constructing drug-loaded nanoparticles apatinib/Ce6@ZIF-8@Membranes (aCZM) to enhance therapeutic targeting and reduce toxic side following sonodynamic therapy (SDT). Methods: apatinib/Ce6@ZIF-8 (aCZ) were synthesized by situ encapsulation, aCZM constructed encapsulating with extracted breast cancer cell membranes. characterized tested for stability electron microscopy, membrane proteins on...
Objective To investigate the effects and potential mechanism of action shikonin (SHK) on development ovarian follicles female germline stem cells (FGSCs). Methods Female Kunming adult mice were administered SHK (0, 20 50 mg/kg) by oral gavage. Cultures FGSCs treated with 32 μmol/l for 24 h. The index in mouse ovaries was calculated. Numbers primordial, primary atretic counted. Germline cell markers apoptosis examined. Levels glutathione (GSH), superoxide dismutase (SOD) reactive oxygen...
Flood disaster will cause large area power outage of the distribution network, causing huge economic loss. Emergency supply is an effective strategy to improve ability network deal with flood disaster. However, due limitation water, it difficult for emergency reach accident site, so mobile needs be configured in advance. In this paper, a two-stage optimization model improving resilience proposed. Considering vulnerability modeling different equipment under disaster, multiple island...
Under the dual carbon target, it is a big problem for power grid enterprises to accurately invest and help high-quality construction of new systems. situation large-scale energy connection, investment strategy needs be more reasonable efficient. Therefore, this paper proposes single project evaluation method based on combination weighting method, which provides basis ranking projects, also theoretical support solving decision-making projects