A5100318651- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Genetic factors in colorectal cancer
- Radiomics and Machine Learning in Medical Imaging
- Pancreatic and Hepatic Oncology Research
- Epigenetics and DNA Methylation
- Lung Cancer Research Studies
- Cancer Mechanisms and Therapy
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gut microbiota and health
- Cancer Cells and Metastasis
- Esophageal Cancer Research and Treatment
- Clostridium difficile and Clostridium perfringens research
- Lung Cancer Diagnosis and Treatment
- RNA Research and Splicing
- Genetics, Aging, and Longevity in Model Organisms
- Bladder and Urothelial Cancer Treatments
- Biochemical and Molecular Research
- Neuropeptides and Animal Physiology
- Ferroptosis and cancer prognosis
- Bioactive natural compounds
- Circadian rhythm and melatonin
Burning Rock Biotech (China)
2021-2025
Xi'an Jiaotong University
2023-2024
Xi'an Honghui Hospital
2023-2024
Qingdao University
2024
Affiliated Hospital of Qingdao University
2024
Southwest University
2024
Tsinghua University
2022-2023
Neoleukin Therapeutics (United States)
2023
Rutgers, The State University of New Jersey
2022
Nanjing Medical University
2020
Tumor mutational burden (TMB), as measured by whole-exome sequencing (WES) or a cancer gene panel (CGP), is associated with immunotherapy responses. However, whether TMB estimated circulating tumor DNA in blood (bTMB) clinical outcomes of remains to be explored.To explore the optimal size and algorithm design CGP for estimation, evaluate reliability, further validate feasibility bTMB actionable biomarker immunotherapy.In this cohort study, named NCC-GP150 was designed virtually validated...
Several studies have linked gut microbiota to human brain activity. This study used Mendelian randomization (MR) investigate the causal relationship between microbes and delirium.MR was select SNPs from large-scale GWAS summary data on 211 taxa delirium. Inverse variance weighting (IVW), weighted median, MR-Egger methods were for statistical analyses. Outliers assessed using leave-one-out method. To avoid horizontal pleiotropy, we performed MR-PRESSO intercept tests. Cochran's Q I2 values...
Abstract Recent studies demonstrate the functions of long non-coding RNAs (lncRNAs) in mediating gene expression at transcriptional or translational level. Our previous study identified a Sirt1 antisense (AS) lncRNA transcribed from AS strand. However, its role and regulatory mechanism is still unknown myogenesis. Here, functional analyses showed that overexpression promoted myoblast proliferation, but inhibited differentiation. Mechanistically, was found to activate sense gene, . The...
NOTCH signaling is associated with tumorigenesis, mutagenesis, and immune tolerance in non-small cell lung cancer (NSCLC), indicating its association the clinical benefit of checkpoint inhibitors (ICI). We hypothesized that mutation NSCLC might be a robust predictor immunotherapeutic efficacy.Multiple-dimensional data including genomic, transcriptomic, from cohorts internal public involving patients were analyzed. Polymorphism Phenotyping v2 (PolyPhen-2) system was performed to determine...
Background & Aims: SLC25A47 was initially identified as a mitochondrial HCC-downregulated carrier protein, but its physiological functions and transport substrates are unknown. We aimed to investigate the role of in hepatic metabolism. Approach Results: In treatment hepatocytes with metformin, we found that metformin can transcriptionally activate expression Slc25a47 , which is required for AMP-activated protein kinase α (AMPKα) phosphorylation. -deficient mice had increased lipid...
Intramuscular fat (IMF), which is modulated by adipogenensis of intramuscular adipocytes, plays a key role in pork quality associated with marbling, juiceness, and flavor. However, the regulatory mechanism 1-deoxynojirimycin (DNJ) on adipogenesis still unknown. Here, we found that both DNJ (2.0, 3.0, 4.0, 5.0, 6.0 μM) rosiglitazone (RSG; 0.1, 0.2, 0.3, 0.4, 0.5 mM) had no effect cell viability. Moreover, 4 μM significantly inhibited adipogenesis, whereas 0.4 mM RSG increased lipogenesis...
Abstract Background This study aimed to reveal the association between gut microbiota (GM) and six diabetic complications: hypoglycemia; ketoacidosis; nephropathy; neuropathy; retinopathy; Charcot’s foot. Methods GM data were obtained from MiBioGen consortium Dutch Microbiome Project while on complications FinnGen consortium. Two-sample Mendelian randomization (TSMR) was performed explore common complications. Inverse MR analysis conducted examine effect of identified GM. Sensitivity tests...
Abstract Background Plasma cell-free DNA (cfDNA) methylation has shown promising results in the early detection of multiple cancers recently. Here, we conducted a study to investigate performance cfDNA esophageal cancer (ESCA). Methods Specific markers for ESCA were identified and optimized based on tumor paired adjacent tissues ( n = 24). Age-matched participants with 85), benign diseases 10), healthy controls 125) randomized into training test sets develop classifier differentiate from...
Abstract Rapeseed meal (RSM) is an important source of protein, but its value limited due to the poor digestibility and presence many antinutritional factors. In this study, a two‐step biological method was developed for detoxifying RSM increasing protein value. first stage, various enzymes proteases were produced by Aspergillus niger during solid‐state fermentation (SSF). second coordinated enzymatic hydrolysis employed further degrade factors macromolecular proteins in fermented RSM....
To investigate the prognostic value of pre-ablation stimulated thyroglobulin (ps-Tg) in children and adolescents with persistent differentiated thyroid cancer (DTC) following initial radioiodine therapy (RAI).
About 10–15% patients who take statins experience skeletal muscle problems. Red yeast rice has a good safety profile could provide compromise therapeutic strategy. Therefore, the aim of this study was to evaluate effects red rice, when compared simvastatin, on fatigue symptom and serum lipid level in dyslipidemic with low moderate cardiovascular risk. A total 60 risk were recruited randomly assigned receive either simvastatin (n = 33) or 27) for 4 weeks. The score, physical activity, then...
Abstract Background Isocitrate dehydrogenase (IDH) is an enzyme family involved in cell aerobic metabolism of tricarboxylic acid cycle. However, the landscape IDH mutations pan‐cancer has not been fully characterized. Methods Tissue or blood samples were subjected to next‐generation sequencing (NGS) for detection mutation. Results A total 28.868 patients from more than 20 solid tumor species analyzed. 374 cases (1.30%) with identified. Among all cases, 80 (21.4%) biliary tract cancer (BTC),...
459 Background: Early detection of cancer can potentially offer clinical benefits, particularly for those without effective screening methods. The PREDICT study (pan-cancer early project, NCT 04383353) is a prospective, multi-center, longitudinal that aims to identify multiple cancers non-invasively before symptoms become apparent. As pilot the THUNDER (the unintrusive early-stage cancer) designed development and validation ELSA-seq, sensitive targeted methylation sequencing assay...
Mitochondrial health is crucial to sperm quality and male fertility, but the precise role of mitochondria in function remains unclear. SDHA a component succinate dehydrogenase (SDH) complex plays critical mitochondria. In humans, SDH activity positively correlated with quality, mutations are associated Leigh Syndrome. Here we report that