A5100451809- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- RNA Research and Splicing
- Nitric Oxide and Endothelin Effects
- Mitochondrial Function and Pathology
- Cancer, Hypoxia, and Metabolism
- Neurological Disease Mechanisms and Treatments
- Epigenetics and DNA Methylation
- Eicosanoids and Hypertension Pharmacology
- Autophagy in Disease and Therapy
- Signaling Pathways in Disease
- RNA Interference and Gene Delivery
- Cardiac Ischemia and Reperfusion
- Antenna Design and Analysis
- RNA regulation and disease
- Pulsars and Gravitational Waves Research
- Cytokine Signaling Pathways and Interactions
- Nutrition, Genetics, and Disease
- Endoplasmic Reticulum Stress and Disease
- Stellar, planetary, and galactic studies
- Sirtuins and Resveratrol in Medicine
- Alcohol Consumption and Health Effects
- Neuroinflammation and Neurodegeneration Mechanisms
Beijing University of Chinese Medicine
2024-2025
Harbin Medical University
2013-2025
Hebei Medical University
2013-2025
Guangzhou University of Chinese Medicine
2024-2025
Lanzhou University
2024-2025
Second Affiliated Hospital of Chongqing Medical University
2025
Dalian Medical University
2025
Chongqing Medical University
2025
Arizona State University
2020-2025
Army Medical University
2025
Epoxyeicosatrienoic acids (EETs) reduce infarction of the myocardium after ischemia-reperfusion injury to rodent and dog hearts mainly by opening sarcolemmal mitochondrial potassium channels. Other mediators for action EET have been proposed, although no definitive pathway or mechanism has yet reported. Using cultured cells from two species, immortalized myocytes a mouse atrial lineage (HL-1) primary derived neonatal rat hearts, we observed that pretreatment with EETs (1 μM 14,15-, 11,12-,...
// Weiqi Dai 1,* , Fan Wang Jie Lu Yujing Xia 1 Lei He Kan Chen Jingjing Li Sainan Tong Liu Yuanyuan Zheng Jianrong 1,2 Wenxia Yuqing Zhou 1,3 Qin Yin Huerxidan Abudumijiti Rongxia Rong Zhang Zhu Jing Yang Chengfen Huawei Yingqun Ling Xu 4 and Chuanyong Guo Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School Medicine, Shanghai, China 2 The First Clinical Medical College Nanjing University, Nanjing, 3 Affiliated Hospital Soochow Suzhou, Tongren Jiaotong...
Previous studies have demonstrated that chronic brain hypoperfusion (CBH) causes Aβ aggregation by upregulating expression of amyloid precursor protein (APP) and β-site APP cleaving enzyme 1 (BACE1) protein, which is accompanied cognitive impairment, but the mechanisms are not fully understood. In this study, we evaluated effect microRNA on memory impairment in rats induced CBH. We show here CBH generated bilateral common carotid artery occlusion (2VO) significantly decreased learning...
ABSTRACT P73 antisense RNA 1T (non‐protein coding), also known as TP73‐AS1 or PDAM, is a long non‐coding which may regulate apoptosis via regulation of p53‐dependent anti‐apoptotic genes. An abnormal change expression was noticed in cancers. The effects brain glioma growth and the underlying mechanism remain unclear so far. In present study, specifically upregulated tissues cell lines, associated with poorer prognosis patients glioma. knocking down suppressed human proliferation invasion...
Abstract Failure of modularity remains a significant challenge for assembling synthetic gene circuits with tested modules as they often do not function expected. Competition over shared limited expression resources is crucial underlying reason. It was reported that resource competition makes two seemingly separate genes connect in graded linear manner. Here we unveil nonlinear within circuits. We first build cascading bistable switches (Syn-CBS) circuit single strain coupled self-activation...
Soil salinization is a significant threat to agricultural production, making accurate salinity prediction essential. This study addresses key challenges in the Yellow River Delta (YRD) soil inversion, including (1) determining which Landsat 8 OLI level performs better, (2) identifying most suitable month for and (3) improving model performance important variables modeling. Thus images (Level-1 Level-2) 12 months were collected, then having less than 10% cloud cover selected processed extract...
TNF-α activates ASK1 in part by dissociating 14-3-3 from apoptosis signal–regulating kinase 1 (ASK1). In the present study, we identified a novel Ras GTPase-activating protein (Ras-GAP) as an ASK1-interacting (AIP1). AIP1 binds to C-terminal domain of via lysine-rich cluster within N-terminal C2 domain. exists closed form through intramolecular interaction between N-terminus and C-terminus, induces unfolding leading association with ASK1. Thus, containing GAP domains constitutively...
Previously we have shown that ASK-interacting protein 1 (AIP1, also known as DAB2IP), a novel member of the Ras-GAP family, mediates TNF-induced activation ASK1-JNK signaling pathway. However, mechanism by which TNF is coupled to AIP1 not known. Here show localized on plasma membrane in resting endothelial cells (EC) complex with TNFR1. binding induces release from TNFR1, resulting cytoplasmic translocation and concomitant formation an intracellular comprised TRADD, RIP1, TRAF2, AIPl. A...
Activation of cellular Ca2+ signaling molecules appears to be a fundamental step in the progression cardiomyopathy and arrhythmias. Myocardial overexpression constitutively active Ca2+-dependent phosphatase calcineurin (CAN) causes severe marked by left ventricular (LV) dysfunction, arrhythmias, increased mortality rate, but CAN antagonist drugs primarily reduce hypertrophy without improving LV function or risk death.We found that activity expression second Ca2+-activated molecule,...
Myocardial Ca2+/calmodulin-dependent protein kinase II (CaMKII) inhibition improves cardiac function following myocardial infarction (MI), but the CaMKII-dependent pathways that participate in stress responses are incompletely understood. To address this issue, we sought to determine transcriptional consequences of CaMKII after MI. We performed gene expression profiling mouse hearts with cardiomyocyte-delimited transgenic either a inhibitory peptide (AC3-I) or scrambled control (AC3-C) Of...
The type II p21-activated kinases (PAKs) are key effectors of RHO-family GTPases involved in cell motility, survival, and proliferation. Using a structure-guided approach, we discovered that PAKs regulated by an N-terminal autoinhibitory pseudosubstrate motif centered on critical proline residue, this regulation occurs independently activation loop phosphorylation. We determined six X-ray crystal structures either full-length PAK4 or its catalytic domain, demonstrate the molecular basis for...
microRNAs (miRNAs) are important regulators of gene expression during tumorigenesis. The downregulation microRNA-9 (miR-9) has been reported in ovarian serous carcinoma (OSC), indicating a role for miR-9 this type cancer. In study, we investigated the biological significance OSC vitro. Using 3 cell lines, SKOV3, CAOV3 and OVCAR3, which underexpresss miR-9, demonstrate that exogenous transfection inhibits proliferation, migration invasion. addition, focal adhesion protein, talin 1 (TLN1),...
Background MicroRNA-206 (miR-206), as a homolog of miR-1, plays important roles in tumorigenesis and tumor progression various human malignancies, including breast cancer, endometrial endometrioid carcinoma, rhabdomyosarcoma, glioma, lung laryngeal cancer. However, its involvement gastric cancer has remained unclear. Aim To examine the expression patterns clinical implications miR-206 Materials methods Quantitative RT-PCR was performed to evaluate levels 98 pairs normal adjacent mucosa. In...
Abstract Nasopharyngeal carcinoma (NPC) is a malignant tumor originating in the epithelium. Radiotherapy standard therapy, but resistance to this treatment reduces 5-year patient survival rate dramatically. Studies are urgently needed elucidate mechanism of NPC radioresistance. Epigenetics—particularly microRNAs (miRNA) and DNA methylation—plays an important role carcinogenesis oncotherapy. We used qRT-PCR analysis identified miRNA signature from differentially expressed miRNAs. Our...
Pathological cardiac hypertrophy (CH) is a key factor leading to heart failure and ultimately sudden death. Long non-coding RNAs (lncRNAs) are emerging as new player in gene regulation relevant wide spectrum of human disease including disorders. Here, we characterize the role specific lncRNA named hypertrophy-associated regulator (CHAR) CH delineate underlying signalling pathway. CHAR was found markedly down-regulated both vivo mouse model induced by pressure overload vitro cellular...
Plastics breaking down of larger plastics into smaller ones (microplastics and nanoplastic) as potential threats to the ecosystem. Previous studies demonstrate that central nervous system (CNS) is a vulnerable target nanoplastics. However, potentially epigenetic biomarkers nanoplastic neurotoxicity in rodent models are still unknown. The present research aimed determine role competing endogenous RNA (ceRNA) process polystyrene nanoplastics (PS NPs) exposure-induced nerve injury. study was...