A5052966696- Cancer, Lipids, and Metabolism
- Pregnancy and preeclampsia studies
- RNA and protein synthesis mechanisms
- Cytomegalovirus and herpesvirus research
- Peroxisome Proliferator-Activated Receptors
- Immune Cell Function and Interaction
- Drug Transport and Resistance Mechanisms
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Bone health and treatments
- Liver Disease Diagnosis and Treatment
- Toxin Mechanisms and Immunotoxins
- Polyamine Metabolism and Applications
- Birth, Development, and Health
- CRISPR and Genetic Engineering
- HIV-related health complications and treatments
- HIV Research and Treatment
- CAR-T cell therapy research
- HIV/AIDS drug development and treatment
- MicroRNA in disease regulation
- Force Microscopy Techniques and Applications
- Advancements in Semiconductor Devices and Circuit Design
- Fibroblast Growth Factor Research
- Signaling Pathways in Disease
- T-cell and B-cell Immunology
Tsinghua University
2017-2024
Sichuan University
2019-2022
State Key Laboratory of Biotherapy
2022
Beijing Advanced Sciences and Innovation Center
2019
Objective Increased de novo fatty acid (FA) synthesis and cholesterol biosynthesis have been independently described in many tumour types, including hepatocellular carcinoma (HCC). Design We investigated the functional contribution of synthase (Fasn)-mediated FA a murine HCC model induced by loss Pten overexpression c-Met (sgPten/c-Met) using liver-specific Fasn knockout mice. Expression arrays lipidomic analysis were performed to characterise global gene expression lipid profiles,...
Ameliorating T cell exhaustion and enhancing effector function are promising strategies for the improvement of immunotherapies. Here, we show that HPK1-NFκB-Blimp1 axis mediates dysfunction. High expression MAP4K1 (which encodes HPK1) correlates with increased worse patient survival in several cancer types. In MAP4K1KO mice, tumors grow slower than wild-type mice infiltrating cells less exhausted more active proliferative. We further genetic depletion, pharmacological inhibition, or...
Background & Aims: SLC25A47 was initially identified as a mitochondrial HCC-downregulated carrier protein, but its physiological functions and transport substrates are unknown. We aimed to investigate the role of in hepatic metabolism. Approach Results: In treatment hepatocytes with metformin, we found that metformin can transcriptionally activate expression Slc25a47 , which is required for AMP-activated protein kinase α (AMPKα) phosphorylation. -deficient mice had increased lipid...
Abstract Monocarboxylate transporter 1 (MCT1) exhibits essential roles in cellular metabolism and energy supply. Although MCT1 is highly expressed activated B cells, it not clear how MCT1-governed monocarboxylates transportation functionally coupled to antibody production during the glucose metabolism. Here, we report that cell-lineage deficiency of significantly influences class-switch recombination (CSR), rendering impaired IgG responses Mct1 f/f Mb1 Cre mice after immunization. Metabolic...
Abstract Despite the therapeutic success of tenofovir (TFV) for treatment HIV-1 infection, numerous cases nephrotoxicity have been reported. Mitochondrial toxicity has purported as major target TFV-associated renal tubulopathy but underlying molecular mechanism remains unclear. In this report, we use metabolomics and proteomics with HK-2 cells animal models to dissect pathways nephropathy caused by TFV its more toxic analog, adefovir (ADV). Proteomic analysis shows that mitochondrial...
Zoledronate is a bisphosphonate that widely used in the treatment of metabolic bone diseases. However, zoledronate induces significant nephrotoxicity associated with acute tubular necrosis and renal fibrosis when administered intravenously. There speculation zoledronate-induced may result from its pharmacological activity as an inhibitor mevalonate pathway but molecular mechanisms are not fully understood. In this report, human proximal HK-2 cells mouse models were combined to dissect...
Abstract Preeclampsia (PE) occurs only in humans and some non‐human primates, making its pathogenesis difficult to study. The aetiology of PE is mainly caused by a deficiency trophoblast differentiation spiral artery remodelling. angiogenic factor Placental Growth Factor (PlGF) or the ratio sFlt‐1 PlGF cell‐free RNA have been used as main biomarkers for predicting PE. Now, Lee colleagues show that cluster 147 (CD147) results preeclampsia pathophysiology. This contribution makes sheds light...