A5100335304- Microtubule and mitosis dynamics
- Adenosine and Purinergic Signaling
- RNA modifications and cancer
- Cancer Research and Treatments
- interferon and immune responses
- Connexins and lens biology
- Ubiquitin and proteasome pathways
- Cancer-related Molecular Pathways
- Mitochondrial Function and Pathology
- Immune Response and Inflammation
- Endoplasmic Reticulum Stress and Disease
- Cellular transport and secretion
- Plant Pathogens and Fungal Diseases
- Histone Deacetylase Inhibitors Research
- Mycorrhizal Fungi and Plant Interactions
- Genetic and Kidney Cyst Diseases
- Advanced biosensing and bioanalysis techniques
- Amino Acid Enzymes and Metabolism
- Genomics and Phylogenetic Studies
- ATP Synthase and ATPases Research
- Signaling Pathways in Disease
- Genetics and Neurodevelopmental Disorders
- Hippo pathway signaling and YAP/TAZ
- Cancer, Hypoxia, and Metabolism
- Peptidase Inhibition and Analysis
First Affiliated Hospital of Henan University
2025
Zhejiang University
2008-2024
Boston Children's Hospital
2023-2024
Shanghai Jiao Tong University
2021-2024
Ministry of Agriculture and Rural Affairs
2024
State Key Laboratory of Rice Biology
2024
Fudan University Shanghai Cancer Center
2016-2023
Shanghai Medical College of Fudan University
2016-2023
Harvard University
2023
Second Affiliated Hospital of Zhejiang University
2022
In Alzheimer's disease (AD), the mechanisms of neuronal loss remain largely unknown. Although tau pathology is closely correlated with loss, how its accumulation may lead to activation neurotoxic pathways unclear. Here we show that increased levels ubiquitinated proteins in brain and triggered unfolded protein response (UPR). This suggested interferes quality control endoplasmic reticulum (ER). Consistent this, ubiquitin was found associate ER human AD brains transgenic (rTg4510) mouse...
Abstract Ultrafast laser direct writing (ULDW) is explored as a facile technique to induce unprecedented physical phenomena and functional structures three dimensionally in glass. The rapid prototyping compatibility with diversity of materials offer solutions requirements for various applications new emerging platforms photonic circuits networks, quantum platform, optical storage, nonlinear optics, integrated multifunctional chips. In this review, tuning the local thermal accumulation ULDW...
Hepatocellular carcinoma (HCC) is one of the most lethal cancers worldwide. The poor survival may be due to a high proportions tumor recurrence and metastasis. Kinesin family member C1 (KIFC1) highly expressed in variety neoplasms potential marker for non-small cell lung cancer or ovarian adenocarcinoma Nevertheless, role KIFC1 HCC metastasis remains obscure. We investigated this present study using lines clinical specimens. Our results indicated that increased levels were associated with...
Abstract Purpose: FBW7 functions as a tumor suppressor by targeting oncoproteins for destruction. We previously reported that the oncogenic mutation of KRAS inhibits via Ras–Raf–MEK–ERK pathway, which facilitates proliferation and survival pancreatic cancer cells. However, underlying mechanism suppresses remains unexplored. Here, we sought to elucidate function in glucose metabolism malignancy. Experimental Design: Combining maximum standardized uptake value (SUVmax), was obtained...
Hepatocellular carcinoma (HCC) is a heterogeneous malignancy type with limited approaches for treatment. Additionally, inappropriate immune therapy indicates that the understanding underlying mechanism of HCC necessary. The aim present study was to investigate influence novel circular RNA (circRNA), circRNA AR-suppressed PABPC1 91 bp (CircARSP91), on surveillance induced by natural killer (NK) cells. An in vitro cell cytotoxicity assay performed determine NK cells against A specific plasmid...
SARS-CoV-2 infection could cause severe acute respiratory syndrome, largely attributed to dysregulated immune activation and extensive lung tissue damage. However, the underlying mechanisms are not fully understood. Here, we reported that viral induce syncytia formation within cells expressing ACE2 spike protein, leading production of micronuclei with an average rate about 4 per syncytium (> 93%). Remarkably, these were manifested a high level both DNA damage response cGAS-STING signaling,...
Genome mining targeting unique type II PKS and NRPS led to the identification of a novel class glycopeptides named kitacinnamycins.
Abstract Proton-linked monocarboxylate transporters (MCTs) must transport efficiently to facilitate efflux in glycolytically active cells, and slowly or even shut down maintain a physiological concentration inactive cells. To discover how MCTs solve this fundamental aspect of intracellular homeostasis the context multicellular organisms, we analyzed pyruvate activity human transporter 2 (MCT2). Here show that MCT2 exhibits steep dependence on substrate concentration. This property allows...
Therapeutic resistance developed after chemotherapy and aggressive metastasis are the major causes of cancer-related death in patients with triple-negative breast cancer (TNBC). Survivin is smallest member inhibitor-of-apoptosis proteins (IAPs) family, which plays critical roles cell division survival. High expression levels survivin have been associated therapeutic various cancers. We recently a novel small-molecule inhibitor mimicking IAP-binding motif second mitochondria-derived activator...
Calponin 2 (h2 calponin, CNN2) is an actin-binding protein implicated in cytoskeletal organization. We have found that the expression of calponin relatively restricted to vasculature from 16 30 h post-fertilization during zebrafish (Danio rerio) development. Forty-eight hours after injecting antisense morpholino oligos against into embryos at 1-4-cell stage, demonstrated various cardiovascular defects, including sluggish axial and head circulation, absence circulation intersegmental vessels...
// Junmou Hong 1,* , Zhenguo Liu Hua Zhu 2 Xin Zhang 1 Yongju Liang 3 Shiyuan Yao Fang Wang Xiaoyun Xie 4 Bo Tao Tan Liwu Fu Jing Nie 5 and Chao Cheng Department of Thoracic Surgery, The First Affiliated Hospital Sun Yat-sen University, Guangzhou, People's Republic China Davis Heart Lung Research Institute, Ohio State University Wexner Medical Center, Columbus, OH, USA Key Laboratory Oncology in South China, Cancer Division Geriatrics, Tongji Hospital, School Medicine, Shanghai, Nephrology,...