A5032649134- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Pluripotent Stem Cells Research
- Cardiac Fibrosis and Remodeling
- Cardiac Ischemia and Reperfusion
- Nerve injury and regeneration
- Corneal Surgery and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Cardiovascular Function and Risk Factors
- Tracheal and airway disorders
- Cardiovascular and exercise physiology
- Periodontal Regeneration and Treatments
- Wound Healing and Treatments
- Muscle Physiology and Disorders
- Retinal Diseases and Treatments
- Mechanical Circulatory Support Devices
- Cardiac Health and Mental Health
- Adipose Tissue and Metabolism
- Multiple Sclerosis Research Studies
- Vascular Anomalies and Treatments
- Cardiovascular Effects of Exercise
- Congenital heart defects research
- Selenium in Biological Systems
- RNA Interference and Gene Delivery
University of Illinois Chicago
2023
Faculdade Brasil
2021-2022
Hospital IPO
2008-2021
Princip (Czechia)
2021
Faculdade São Leopoldo Mandic
2020
Hospital Erasto Gaertner
2018
Pontifícia Universidade Católica do Paraná
2003-2016
Universidade Federal do Paraná
2006-2016
Instituto de Tecnologia do Paraná
2014
Child, Adolescent and Family Mental Health
2011
Background: Parkinson's disease (PD) is the second most common age-related neurodegenerative disorder. Levodopa (L-DOPA) remains gold-standard drug available for treating PD. Curcumin has many pharmacological activities, including antioxidant, anti-inflammatory, antimicrobial, anti-amyloid, and antitumor properties. Copolymers composed of Poly (ethylene oxide) (PEO) biodegradable polyesters such as (ε-caprolactone) (PCL) can self-assemble into nanoparticles (NPs). This study describes...
FUNDAMENTO: As complicações pulmonares são causas freqüentes do aumento de morbi-mortalidade nos pacientes submetidos à cirurgia cardíaca. A fisioterapia respiratória tem auxiliado na recuperação destes pacientes. OBJETIVO: Analisar o efeito fisioterapêutico da aplicação pressão positiva intermitente (RPPI) e incentivador respiratório (IR) em a revascularização miocárdio. MÉTODOS: Quarenta foram divididos dois grupos: um submetido RPPI (n=20) outro ao IR (n=20). Os avaliados momentos:...
Background: In this study, we developed and validated a HPLC–MS/MS method capable of simultaneously determining levodopa, carbidopa, entacapone, tolcapone, 3-O-methyldopa dopamine in human plasma. Results & methodology: Chromatographic separation was achieved using C8 column with mobile phase consisting gradient water acetonitrile:methanol (90:10 v/v), both containing 0.1% formic acid. The selective, sensitive (LD <7.0 ng ml-1), linear (r > 0.99), precise (RSD < 11.3%), accurate (RE 11.8%)...
Background— Cellular transplantation is emerging as a promising strategy for the treatment of postinfarction ventricular dysfunction. Whether its beneficial effects can be extended to other cardiomyopathies remains an unexplored question. We evaluated histological and functional simultaneous autologous co-cultured stem cells skeletal myoblasts in experimental model dilated cardiomyopathy caused by Chagas disease, characterized diffuse fibrosis impairment microcirculation. Methods Results—...
Posttransplant cell tracking, via stem labeling, is a crucial strategy for monitoring and maximizing benefits of cell-based therapies. The structures functionalities polysaccharides, proteins, lipids allow their utilization in nanotechnology systems.In the present study, we analyzed potential benefit curcumin-loaded nanoparticles (NPC) using Vero cells (in vitro) NPC-labeled adipose-derived mesenchymal (NPC-ADMSCs) vivo) myocardial infarction sciatic nerve crush preclinical models....
In December 2019, COVID-19 emerged in China, and January 2020, the World Health Organization declared a state of international emergency. Within this context, there is significant search for new drugs to fight disease need vitro models preclinical drug tests. This study aims develop 3D lung model. For execution, Wharton's jelly mesenchymal stem cells (WJ-MSC) were isolated characterized through flow cytometry trilineage differentiation. pulmonary differentiation, seeded plates coated with...
The mesenchymal stem cell therapy has proven to be an effective option in the treatment of skin injuries. combination these cells with nanostructured membranes seems future for tissues recovery. aim this project was use biomolecules polysaccharides incorporated on regenerated cellulose and prospect improvement as bioactive wound dressings cells. biocomposites were obtained after defibrillation never-dried bacterial form a pulp, and, films regenerated, presence gellan gum or without...
Biological scaffolds have become an attractive approach for repairing the infarcted myocardium and been shown to facilitate constructive remodeling in injured tissues. This study aimed investigate possible utilization of bacterial cellulose (BC) membrane patches containing cocultured cells limit myocardial postinfarction pathology. Myocardial infarction (MI) was induced by ligating left anterior descending coronary artery 45 Wistar rats, with or without were attached hearts. After one week,...
Aim . The effects of cryopreservation on adipose tissue‐derived mesenchymal stem cells are not clearly documented, as there is a growing body evidence about the importance adipose‐derived for regenerative therapies. aim this study was to analyze human phenotypic expression (CD34, CD45, CD73, CD90, CD105, and CD49d), colony forming unit ability, viability, differentiation potential before after cryopreservation. Materials Methods 12 samples tissue were collected from healthy donor using...
Discarded tissues, like human amniotic membranes and adipose tissue, were investigated for the application of Decellularized Human Amniotic Membrane (DAM) as a viable scaffold transplantation Adipose-derived stromal cells (ASCs) in bone regeneration non-healing calvarial defects rats. membrane was decellularized to provide male Wistar rats ASCs expansion transplantation. osteoinduction vitro promoted deposition mineralized bone-like matrix by ASCs, calcified globular accretions associated...
Purpose: In deep burns, wound contraction and hypertrophic scar formation can generate functional derangement debilitation of the affected part. order to improve quality healing in second-degree we developed a new treatment preclinical model using nanostructured membranes seeded with mesenchymal stem cells (MSCs). Methods: Membranes were obtained by reconstitution bacterial cellulose (reconstituted membrane [RM]) produced dry-cast process, then RM was incorporated 10% tamarind xyloglucan...
Periodontitis is a prevalent disease characterized by the loss of periodontal supporting tissues, bone, ligament, and cementum. The application bone tissue engineering strategy with Decellularized Human Amniotic Membrane (DAM) adipose-derived stromal cells (ASCs) has shown to be convenient valuable. This study aims investigate treatments rat furcation defect model DAM, ASCs, mineralized extracellular matrix (ECM). Rat ASCs were expanded, cultivated on differentiation medium for four weeks,...
Surgical correction of tracheal stenosis is still a complex and challenging procedure. Acellular human amniotic membranes (AHAM) represent promising biomaterial source for tissue regeneration. The aim this study was to evaluate whether AHAM grafts improve regeneration the trachea in rabbit model tracheostomy. Twenty rabbits were randomized into 2 groups. Animals control group underwent surgical tracheostomy only, animals received an graft that covered defect site. We examined tissues at site...