A5005410786- MicroRNA in disease regulation
- Mesenchymal stem cell research
- Sulfur Compounds in Biology
- Cancer-related molecular mechanisms research
- Adipose Tissue and Metabolism
- Circular RNAs in diseases
- Autophagy in Disease and Therapy
- RNA modifications and cancer
- Congenital heart defects research
- Renal and related cancers
- Endometriosis Research and Treatment
- Epigenetics and DNA Methylation
- Tissue Engineering and Regenerative Medicine
- Cardiac Valve Diseases and Treatments
- Heart Failure Treatment and Management
- Antibiotics Pharmacokinetics and Efficacy
- Ferroptosis and cancer prognosis
- Diabetic Foot Ulcer Assessment and Management
- Endometrial and Cervical Cancer Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Nitric Oxide and Endothelin Effects
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiac Imaging and Diagnostics
- Pulmonary Hypertension Research and Treatments
- Osteoarthritis Treatment and Mechanisms
Guizhou Provincial People's Hospital
2021-2025
Guizhou University
2021-2025
Jiangnan University
2025
First Affiliated Hospital of Henan University
2021-2024
Harbin Medical University
2015-2024
Second Affiliated Hospital of Harbin Medical University
2017-2024
Renji Hospital
2019-2024
Shanghai Jiao Tong University
2018-2024
Second Affiliated Hospital of Nanchang University
2024
Nanchang University
2024
Metformin is a widely used antidiabetic drug for type 2 diabetes that can play cardioprotective role through multiple pathways.It recognized agonist of AMP-activated protein kinase (AMPK) blocks mitochondrial complex I.The NLRP3 inflammasome has been demonstrated to be activated in diabetic cardiomyopathy (DCM).However, the metformin regulating signaling pathway DCM remains unclear.It reported AMPK inhibit by activating autophagy.The aim this study was investigate whether AMPK/mTOR DCM.In...
Abstract Diabetes cardiomyopathy (DCM) is a critical complication of long-term chronic diabetes mellitus and characterized by myocardial fibrosis hypertrophy. It has been suggested that DCM related to pyroptosis, programmed cell death associated with inflammation. The long non-coding RNA Kcnq1ot1 involved in different pathophysiological mechanisms multiple diseases, including acute damage arrhythmia. Our previous study found was elevated left ventricular tissue diabetic mice. However,...
The effectiveness of transplanted bone marrow mesenchymal stem cells (MSCs) for cardiac repair has been limited; thus, strategies optimizing stem-cell-based myocardial therapy are needed.The present study was designed to test our central hypothesis that hypoxia-preconditioned MSCs (HP-MSCs) more effective than cultured under ambient oxygen levels the treatment injury in a large-scale (N=49), long-term (9 months), nonhuman primate (Cynomolgous monkeys) investigation.MSCs were engineered...
Diabetic cardiomyopathy (DCM) is a common complication of diabetes and can cause heart failure, arrhythmia sudden death. The pathogenesis DCM includes altered metabolism, mitochondrial dysfunction, oxidative stress, inflammation, cell death extracellular matrix remodeling. Recently, pyroptosis, type programmed related to was proven be activated in DCM. However, the molecular mechanisms underlying pyroptosis remain elusive. long non-coding RNA (lncRNA) Kcnq1ot1 participates many...
Bone marrow-derived mesenchymal stem cells (BMSCs) have been suggested to possess the capacity differentiate into different cell lineages. Maintaining a balanced differentiation program is crucial bone microenvironment and development. MicroRNAs (miRNAs) played critical role in regulating of BMSCs particular lineage. However, miR-149-3p adipogenic osteogenic has not extensively discovered. In this study, we aimed detect expression levels during investigate whether participated lineage choice...
Salt-sensitive hypertension (SSH) is characterized by impaired sodium excretion and subnormal vasodilatory response to salt loading. Sacubitril/valsartan (LCZ696) was hypothesized increase natriuresis diuresis result in superior blood pressure control compared with valsartan Asian patients SSH. In this randomized, double-blind, crossover study, 72 SSH received sacubitril/valsartan 400 mg 320 once daily for 4 weeks each. diagnosed if the mean arterial increased ≥10% when switched from low (50...
Abstract Bone marrow mesenchymal stem cells ( BMSC s) are an expandable population of which can differentiate into osteoblasts, chondrocytes and adipocytes. Dysfunction s in response to pathological stimuli contributes bone diseases. Melatonin, a hormone secreted from pineal gland, has been proved be important mediator formation mineralization. The aim this study was investigate whether melatonin protected against iron overload‐induced dysfunction its underlying mechanisms. Here, we found...
Diabetic cardiomyopathy (DCM) is a vital cause of fatalities in diabetic patients. The programmed death cardiomyocytes and inflammation critically contribute to cardiac hypertrophy fibrosis DCM. Furthermore, circular RNA (circRNA) key regulator various diseases. However, the role circRNAs DCM remains be elucidated. Our previous study found that pyroptosis was markedly activated subjected high-glucose conditions, miR-214-3p regulated expression caspase-1. aim this elucidate whether circRNA...
Bone marrow-derived mesenchymal stem cells (BMSCs) have the potential to differentiate into osteoblasts or adipocytes, and shift between osteogenic adipogenic differentiation determines bone mass. The aim of this study was identify whether lncRNAs are involved in commitment BMSCs during osteoporosis. Here, we found ORLNC1, a functionally undefined lncRNA that is highly conserved, which exhibited markedly higher expression levels BMSCs, tissue, serum OVX-induced osteoporotic mice than...
Melatonin, a hormone secreted by the pineal gland, possesses multiple biological activities such as antitumor, antioxidant, and anti-ischemia. C-kit(+) cardiac progenitor cells (CPCs) have emerged promising tool for treatment of heart diseases. However, senescence CPCs due to pathological stimuli leads decline CPCs' functions regenerative potential. This study was conducted demonstrate whether melatonin antagonizes in response oxidative stress. Here, we found that markedly inhibited...
As a severe public health issue, hearing loss has caused an increasingly disease burden, especially in the elderly population. Hearing may inevitably induce asymmetric hearing, which makes it difficult for individuals to locate sound sources, therefore resulting increased postural instability and falling risk. To emphasize emergence of loss, we investigated temporal trend prevalence over last 30 years further predicted its changes next 20 years, decomposed according demographic factors...
To explore the role of gut dysbiosis-derived β-glucuronidase (GUSB) in development endometriosis (EMs).16S rRNA sequencing stool samples from women with (n = 35) or without 30) and a mouse model was conducted to assess microbiome changes identify molecular factors influencing endometriosis. Experiments vivo an C57BL6 vitro verified level GUSB its EMs.Department Obstetrics Gynecology, The First Affiliated Hospital Sun Yat-sen University; Guangdong Provincial Clinical Research Center for...
Excessive autophagy induced by extravagant oxidative stress is the main reason for diabetes-induced vascular endothelial cells dysfunction. Hydrogen sulfide (H2S) has anti-oxidative effects but its regulation on excessive of unclear. In this study, aorta db/db mice (28 weeks old) and rat aortic (RAECs) treated with 40 mM glucose 500 μM palmitate acted as type II diabetic animal cellular models, respectively, 100 μMNaHS was used an exogenous H2S donor. The apoptosis level measured terminal...
Highlights•Three-dimensional printing of LAA models on the basis 3D TEE images is feasible.•LAA device compression and position in correlate with actual procedure.•Patients implanted matching model testing have better procedural outcomes.•3D guidance for occlusion may lead to improved outcomes.AbstractBackgroundLeft atrial appendage (LAA) an alternative anticoagulation stroke prevention patients fibrillation. Accurate sizing crucial optimal outcome. Patient-specific can be created using...
Accumulating evidence revealed that mesenchymal stem cells (MSCs) confer cardioprotection against myocardial infarction (MI). However, the poor survival and engraftment rate of transplanted limited their therapeutic efficacy in heart. The enhanced leptin production associated with hypoxia preconditioning contributed to improved MSCs survival. Mitochondrial integrity determines cellular fate. Thus, we aimed investigate whether can enhance mitochondrial human (hMSCs) protect various stress. In...
Background: Oxidative stress inducing hyperglycemia and high glucose play an important role in the development of cardiac fibrosis associated with diabetic cardiomyopathy. The endogenous gasotransmitter hydrogen sulfide (H2S) can act a cytoprotective manner. However, whether H2S could inhibit fibrotic process is unclear. purpose our study was to examine underlying mechanisms behind Methods: Diabetic cardiomyopathy induced rats by injection streptozotocin (STZ). Cardiac proliferation rat...
Osteoporosis is closely associated with the dysfunction of bone metabolism, which caused by imbalance between new formation and resorption. Osteogenic differentiation plays a vital role in maintaining balance microenvironment. The present study investigated whether melatonin participated osteogenic commitment marrow mesenchymal stem cells (BMSCs) further explored its underlying mechanisms. Our data showed that exhibited capacity regulating BMSCs, was blocked membrane receptor inhibitor...
Background/Aims: Blue light emitting diodes (LEDs) have been proven to affect the growth of several types cells. The effects blue LEDs not tested on bone marrow-derived mesenchymal stem cells (BMSCs), which are important for cell-based therapy in various medical fields. Therefore, aim this study was determine LED proliferation, apoptosis and osteogenic differentiation BMSCs. Methods: BMSCs were irradiated with a at 470 nm 1 min, 5 10 30 min 60 or irradiated. Cell proliferation measured by...