A5071949220- Corneal Surgery and Treatments
- CRISPR and Genetic Engineering
- Corneal surgery and disorders
- Birth, Development, and Health
- Renal and related cancers
- Pluripotent Stem Cells Research
- Hydrogen's biological and therapeutic effects
- Mathematical Biology Tumor Growth
- Virus-based gene therapy research
- Chemical Reactions and Isotopes
- Retinal Development and Disorders
- Modular Robots and Swarm Intelligence
- Tissue Engineering and Regenerative Medicine
- Dietary Effects on Health
- Cancer Cells and Metastasis
- Developmental Biology and Gene Regulation
Bashkir State Medical University
2017-2021
Harbin Medical University
2017-2019
First Affiliated Hospital of Harbin Medical University
2017-2019
Heilongjiang Academy of Sciences
2017
Abstract Bone marrow mesenchymal stem cells ( BMSC s) are an expandable population of which can differentiate into osteoblasts, chondrocytes and adipocytes. Dysfunction s in response to pathological stimuli contributes bone diseases. Melatonin, a hormone secreted from pineal gland, has been proved be important mediator formation mineralization. The aim this study was investigate whether melatonin protected against iron overload‐induced dysfunction its underlying mechanisms. Here, we found...
Abstract Corneal disease is the second most common blinding in world. The shortage of cornea donors has become greatest challenge curing corneal disease. Decellularized porcine corneas have potential to be clinically applied as a substitute for human lamellar keratoplasty. Porcine will help relieve donor shortage. To comprehensively evaluate characteristics grafts and effect decellularized on host after clinical transplantation, we assessed microstructure transplanted tissues. Through...
The corneal endothelium (CE) is vital for the cornea to maintain its transparency. However, CE dysfunction occurs due aging, intraocular surgery, trauma, dystrophy, etc. Corneal transplantation only method clinically treat dysfunction; however, this treatment strategy faces disadvantages of a global shortage, graft failure, and severe side effects. There recognized need substitute CE. Stem cells are becoming increasingly common human diseases. In fact, several studies have documented...
A human corneal stroma induced pluripotent stem cell (HMUi001-A) line was created from primary cultured fibroblasts. Reprogramming performed using episomal vector delivery of OCT4, SOX2, KLF4, L-MYC and LIN28. Further characterization the HMUi001-A confirmed that pluripotent, free Epstein Barr viral genome, retained normal karyotype.
This scientific literature review demonstrates high prospects of recent developments in gene therapy for the treatment retinal diseases. First all it concerns inherited pathologies such as retinitis pigmentosa and Leber congenital amaurosis. Nevertheless is still quite far from its tangible application clinical practice other diseases, although preliminary trial outcomes use some them (for example, achromatopsia, X-linked retinoschisis) turn to be very promising. The data presented this...
3D model of the cornea in vitro: “Cornea-on-a-Chip”, simulating human eye and most accurately recreating complex local biophysiological processes body. Technologies used development process include microfluidics, sterolithography bioengineering. Such “Cornea-on-a-Chip” devices could be for biomedical research pharmacological testing drugs, potentially reducing need to use animals laboratory improving quality research.
A systematic analysis of the normal composition microorganisms human ocular surface will help to systematize knowledge, which in future may become important for identifying results and bacteriological studies treatment prevention.
An analytical review of literature data modern studies monocyte migration (movement) in tumor microenvironment using various three-dimensional models is presented. The given can serve as a characteristic an optimal platform for studying the functions both individual cell populations immune cells and whole ensembles development therapy malignant neoplasms. One most important characteristics model, which has significant impact on its prognostic ability, cellular composition used. clearly...
The shortage of donor corneas for keratoplasty in patients with severe disorders (persistent opacity, corneal leucoma IV–V categories, including vascularization, after burns, multiple transplant failures, extensive symblepharon, Stevens – Johnson syndrome, Lyell's ocular cicatricial pemphigoid, etc) is currently compensated by keratoprostheses, which partly or completely consist synthetic materials, show good engraftment and high vision restoration efficacy. article a review main scientific...