A5072861880- Peptidase Inhibition and Analysis
- Folate and B Vitamins Research
- RNA modifications and cancer
- Circular RNAs in diseases
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Pregnancy and preeclampsia studies
- Lung Cancer Treatments and Mutations
- Congenital heart defects research
- Hydrogen's biological and therapeutic effects
- Laser Applications in Dentistry and Medicine
- Gastric Cancer Management and Outcomes
- Genetic factors in colorectal cancer
- MXene and MAX Phase Materials
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Research Studies
- Advanced Photocatalysis Techniques
- Gestational Diabetes Research and Management
- Immune Response and Inflammation
- Medical Research and Treatments
- Helicobacter pylori-related gastroenterology studies
- Nanocluster Synthesis and Applications
- RNA Research and Splicing
Union Hospital
2016-2025
Huazhong University of Science and Technology
2015-2025
Shenzhen Institutes of Advanced Technology
2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2024
Chongqing Medical University
2018-2024
Affiliated Hospital of Guizhou Medical University
2024
Guiyang Medical University
2024
Harbin Medical University
2017-2023
Second Affiliated Hospital of Harbin Medical University
2017-2023
Wuhan University
2008-2023
N6-methyladenosine (m6A) RNA modification, a dynamic and reversible process, is essential for tissue development pathogenesis. However, the potential involvement of m6A in regulation cardiomyocyte (CM) proliferation cardiac regeneration remains unclear. In this study, we aimed to investigate role modification heart during postnatal adult injury. Methods results: identified downregulation demethylase ALKBH5, an "eraser" that responsible increased methylation, after birth. Notably, ALKBH5...
Bone marrow-derived mesenchymal stem cells (BMSCs) have been suggested to possess the capacity differentiate into different cell lineages. Maintaining a balanced differentiation program is crucial bone microenvironment and development. MicroRNAs (miRNAs) played critical role in regulating of BMSCs particular lineage. However, miR-149-3p adipogenic osteogenic has not extensively discovered. In this study, we aimed detect expression levels during investigate whether participated lineage choice...
Methyltransferase-like 3 (METTL3) is the main enzyme for N6-methyladenosine (m6A)-based methylation of RNAs and it has been implicated in many biological pathophysiological processes. In this study, we aimed to explore potential involvement METTL3 osteoblast differentiation decipher underlying cellular molecular mechanisms. We demonstrated that downregulated human osteoporosis ovariectomized (OVX) mouse model, as well during osteogenic differentiation. Silence by short interfering RNA...
Abstract Bone marrow mesenchymal stem cells ( BMSC s) are an expandable population of which can differentiate into osteoblasts, chondrocytes and adipocytes. Dysfunction s in response to pathological stimuli contributes bone diseases. Melatonin, a hormone secreted from pineal gland, has been proved be important mediator formation mineralization. The aim this study was investigate whether melatonin protected against iron overload‐induced dysfunction its underlying mechanisms. Here, we found...
Bone marrow-derived mesenchymal stem cells (BMSCs) have the potential to differentiate into osteoblasts or adipocytes, and shift between osteogenic adipogenic differentiation determines bone mass. The aim of this study was identify whether lncRNAs are involved in commitment BMSCs during osteoporosis. Here, we found ORLNC1, a functionally undefined lncRNA that is highly conserved, which exhibited markedly higher expression levels BMSCs, tissue, serum OVX-induced osteoporotic mice than...
Bladder cancer is one of the most common malignant tumors urinary system and associated with a poor prognosis once invasion distant metastases occur. Epithelial-mesenchymal transition (EMT) drives metastasis in bladder cancer. Transforming growth factor β1 (TGF-β1) stromal fibroblasts, especially cancer-associated fibroblasts (CAFs), are positive regulators EMT However, it remains unclear how TGF-β1 mediates crosstalk between cells CAFs induces fibroblast-mediated We aimed to investigate...
BackgroundInterleukin (IL)-32 is a recently described pro-inflammatory cytokine that has been reported to be induced by bacteria treatment in culture cells. Little known about IL-32 production exogenous pathogens infection human individuals.Methods and FindingsIn this study, we found level was increased 58.2% the serum samples from cohort of 108 patients infected influenza A virus comparing 115 healthy individuals. Another factor cyclooxygenase (COX)-2-associated prostaglandin E2 also...
Chronic inflammation induced by hepatitis B virus (HBV) is a major causative factor associated with the development of cirrhosis and hepatocellular carcinoma. In this study, we investigated roles three inflammatory factors, IL-8, IL-29 (or IFN-λ1), cyclooxygenase-2 (COX-2), in HBV infection. We showed that expression IL-29, COX-2 genes was enhanced HBV-infected patients or HBV-expressing cells. HBV-transfected human lymphocytes hepatocytes, activates production which turn enhances COX-2....
Osteoporosis is closely associated with the dysfunction of bone metabolism, which caused by imbalance between new formation and resorption. Osteogenic differentiation plays a vital role in maintaining balance microenvironment. The present study investigated whether melatonin participated osteogenic commitment marrow mesenchymal stem cells (BMSCs) further explored its underlying mechanisms. Our data showed that exhibited capacity regulating BMSCs, was blocked membrane receptor inhibitor...
Background/Aims: Blue light emitting diodes (LEDs) have been proven to affect the growth of several types cells. The effects blue LEDs not tested on bone marrow-derived mesenchymal stem cells (BMSCs), which are important for cell-based therapy in various medical fields. Therefore, aim this study was determine LED proliferation, apoptosis and osteogenic differentiation BMSCs. Methods: BMSCs were irradiated with a at 470 nm 1 min, 5 10 30 min 60 or irradiated. Cell proliferation measured by...
iNOS plays an important role in mediating inflammation. In this study, we found that iNOS-derived NO was increased 2.4-fold the serum samples of 101 patients infected with influenza A virus comparison 105 healthy individuals. A549 human lung epithelial cells, infection or stimulation poly(I:C)+IFN-gamma resulted mRNA and protein levels both IL-32 iNOS, subsequent release NO. Over-expression upregulated expression production. Knock down by IL-32-specific siRNA inhibition dsRNA-induced...
// Fan Yang 2, * , Yuan Li Gege Yan 2 Tianyi Liu Chao Feng Rui Gong Ye 3 Fengzhi Ding Lai Zhang Elina Idiiatullina 4 Valentin Pavlov Zhenbo Han Wenya Ma Qi Huang Ying Yu Zhengyi Bao Xiuxiu Wang Bingjie Hua Zhimin Du Benzhi Cai Lei 1 Department of Orthopedics, The First Affiliated Hospital Harbin Medical University, 150001, China Pharmacology, College Pharmacy, 150081, Clinical Second 150086, Central Laboratory Scientific Research, Bashkir State Ufa 450008, Russia These authors contributed...
N6-methyladenosine (m6A), as the most abundant modification of mammalian messenger RNAs, is essential for tissue development and pathogenesis. However, biological significance m6A methylation in cardiac differentiation remains largely unknown. Here, we identify that downregulation demethylase ALKBH5 responsible increase cardiomyocyte fate determination human embryonic stem cells (hESCs) from mesoderm (MESs). In contrast, overexpression remarkably blocks hESCs. Mechanistically, KDM5B RBBP5,...
Long non-coding RNA (lncRNA) are a class of RNAs demonstrated to play pivotal roles in regulating tumor progression.Therefore, deciphering the regulatory role lncRNA development glioma may offer promising therapeutic target for treatment glioma.We performed RT-qPCR analysis on expression plasmacytoma variant translocation 1 (PVT1) and miR-365 tissues cell lines.Cell proliferation viability was assessed with CCK8 assay.Cell migration by wound healing assay.Transwell assay used assess invasion...
The role of Helicobacter pylori (H. pylori) infection in the development non-alcoholic fatty liver disease (NAFLD) remains controversial. exact relationship requires further investigation. This study aimed to determine association between them China.A retrospective was conducted on 71,633 participants who underwent physical examinations. 13C urea breath test (13C-UBT) detect H. infection, and ultrasonography used NAFLD.Body mass index (BMI), blood pressure (BP), triglyceride (TG) levels were...
The impact of Helicobacter pylori (H. pylori) eradication on metabolism lipid and the potential predictor such changes remain unclear.This study retrospectively included subjects who underwent at least two 13C urea breath tests between 2015 2019 Wuhan Union Hospital. Based H. examination results, were divided into propensity score-matched persistently negative (HPN), positive (HPP), (HPE) groups. in measurements from before to after eradication, including high-density lipoprotein (HDL),...