A5007950064- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Adipose Tissue and Metabolism
- Autophagy in Disease and Therapy
- Cancer-related gene regulation
- MicroRNA in disease regulation
- Hydrogen's biological and therapeutic effects
- RNA Research and Splicing
- Circular RNAs in diseases
- Land Use and Ecosystem Services
- Exercise and Physiological Responses
- Cancer, Hypoxia, and Metabolism
- Laser Applications in Dentistry and Medicine
- Pluripotent Stem Cells Research
- Renal and related cancers
- Congenital heart defects research
- Lipid metabolism and biosynthesis
- Epigenetics and DNA Methylation
- Adipokines, Inflammation, and Metabolic Diseases
- Iron Metabolism and Disorders
- Protein Tyrosine Phosphatases
- Mesenchymal stem cell research
- Sirtuins and Resveratrol in Medicine
- Advanced biosensing and bioanalysis techniques
- Mitochondrial Function and Pathology
Xi'an University of Architecture and Technology
2025
University of Illinois Chicago
2021-2025
Illinois College
2022-2025
Wuhan Textile University
2024
University of Illinois Urbana-Champaign
2023-2024
National Archives
2023
Chery Automobile (China)
2023
Geely (China)
2023
University College London
2023
Beijing Forestry University
2022-2023
Bone marrow-derived mesenchymal stem cells (BMSCs) have been suggested to possess the capacity differentiate into different cell lineages. Maintaining a balanced differentiation program is crucial bone microenvironment and development. MicroRNAs (miRNAs) played critical role in regulating of BMSCs particular lineage. However, miR-149-3p adipogenic osteogenic has not extensively discovered. In this study, we aimed detect expression levels during investigate whether participated lineage choice...
Methyltransferase-like 3 (METTL3) is the main enzyme for N6-methyladenosine (m6A)-based methylation of RNAs and it has been implicated in many biological pathophysiological processes. In this study, we aimed to explore potential involvement METTL3 osteoblast differentiation decipher underlying cellular molecular mechanisms. We demonstrated that downregulated human osteoporosis ovariectomized (OVX) mouse model, as well during osteogenic differentiation. Silence by short interfering RNA...
Abstract Bone marrow mesenchymal stem cells ( BMSC s) are an expandable population of which can differentiate into osteoblasts, chondrocytes and adipocytes. Dysfunction s in response to pathological stimuli contributes bone diseases. Melatonin, a hormone secreted from pineal gland, has been proved be important mediator formation mineralization. The aim this study was investigate whether melatonin protected against iron overload‐induced dysfunction its underlying mechanisms. Here, we found...
Bone marrow-derived mesenchymal stem cells (BMSCs) have the potential to differentiate into osteoblasts or adipocytes, and shift between osteogenic adipogenic differentiation determines bone mass. The aim of this study was identify whether lncRNAs are involved in commitment BMSCs during osteoporosis. Here, we found ORLNC1, a functionally undefined lncRNA that is highly conserved, which exhibited markedly higher expression levels BMSCs, tissue, serum OVX-induced osteoporotic mice than...
Melatonin, a hormone secreted by the pineal gland, possesses multiple biological activities such as antitumor, antioxidant, and anti-ischemia. C-kit(+) cardiac progenitor cells (CPCs) have emerged promising tool for treatment of heart diseases. However, senescence CPCs due to pathological stimuli leads decline CPCs' functions regenerative potential. This study was conducted demonstrate whether melatonin antagonizes in response oxidative stress. Here, we found that markedly inhibited...
Abstract ALKBH5 is the main enzyme for m 6 A-based demethylation of RNAs and it has been implicated in many biological pathophysiological processes. Here, we aimed to explore potential involvement osteosarcoma decipher underlying cellular/molecular mechanisms. We discovered downregulated levels demethylase were correlated with increased A methylation cells/tissues compared normal osteoblasts cells/tissues. overexpression significantly suppressed cell growth, migration, invasion, trigged...
Abstract The development of osteoporosis is often accompanied by autophagy disturbance, which also causes new osteoblast defects from bone marrow mesenchymal stem cells (BMSCs). However, the underlying molecular mechanisms are still not fully understood. Methyltransferase-like 14 (METTL14) main enzyme for N6-methyladenosine (m6A), most prevalent internal modification in mammalian mRNAs, and it has been implicated many bioprocesses. Herein, we demonstrate that METTL14 plays a critical role...
Mitochondrial dysfunction is a primary driver of cardiac contractile failure; yet, the cross talk between mitochondrial energetics and signaling regulation remains obscure. Ponatinib, tyrosine kinase inhibitor used to treat chronic myeloid leukemia, among most cardiotoxic inhibitors causes dysfunction. Whether ponatinib-induced triggers integrated stress response (ISR) induce cardiotoxicity be determined.
Background/Aims: Bone marrow-derived mesenchymal stem cells (BMSCs) have the ability to differentiate into multilineage such as osteoblasts, chondrocytes, and cardiomyocytes. Dysfunction of BMSCs in response pathological stimuli participates development diseases osteoporosis. Astragalus polysaccharide (APS) is a major active ingredient membranaceus, commonly used anti-aging herb traditional Chinese medicine. The aim this study was investigate whether APS protects against iron...
Abstract A potential therapeutic target to curb obesity and diabetes is thermogenic beige adipocytes. However, adipocytes quickly transition into white upon removing stimuli. Here, we define the critical role of cyclin dependent kinase inhibitor 2A (Cdkn2a) as a molecular pedal for beige-to-white transition. Beige lacking Cdkn2a exhibit prolonged lifespan, male mice confer long-term metabolic protection from diet-induced obesity, along with enhanced energy expenditure improved glucose...
Background/Aims: Blue light emitting diodes (LEDs) have been proven to affect the growth of several types cells. The effects blue LEDs not tested on bone marrow-derived mesenchymal stem cells (BMSCs), which are important for cell-based therapy in various medical fields. Therefore, aim this study was determine LED proliferation, apoptosis and osteogenic differentiation BMSCs. Methods: BMSCs were irradiated with a at 470 nm 1 min, 5 10 30 min 60 or irradiated. Cell proliferation measured by...
Osteoporosis is closely associated with the dysfunction of bone metabolism, which caused by imbalance between new formation and resorption. Osteogenic differentiation plays a vital role in maintaining balance microenvironment. The present study investigated whether melatonin participated osteogenic commitment marrow mesenchymal stem cells (BMSCs) further explored its underlying mechanisms. Our data showed that exhibited capacity regulating BMSCs, was blocked membrane receptor inhibitor...
Resource, environmental, and ecological issues have become major constraints to the development of many regions. The Yellow River Basin is an important barrier for maintaining security in northern China, but it has been impacted by problems such as severe soil erosion declining biodiversity. rational construction patterns enhance ecosystem functions maintain regional security. In this study, a comprehensive assessment system was constructed selecting service importance, sensitivity,...
// Fan Yang 2, * , Yuan Li Gege Yan 2 Tianyi Liu Chao Feng Rui Gong Ye 3 Fengzhi Ding Lai Zhang Elina Idiiatullina 4 Valentin Pavlov Zhenbo Han Wenya Ma Qi Huang Ying Yu Zhengyi Bao Xiuxiu Wang Bingjie Hua Zhimin Du Benzhi Cai Lei 1 Department of Orthopedics, The First Affiliated Hospital Harbin Medical University, 150001, China Pharmacology, College Pharmacy, 150081, Clinical Second 150086, Central Laboratory Scientific Research, Bashkir State Ufa 450008, Russia These authors contributed...
Translational control shapes the proteome and is particularly important in regulating gene expression under stress. A key source of endothelial stress treatment with tyrosine kinase inhibitors (TKIs), which lowers cancer mortality but increases cardiovascular mortality. Using a human induced pluripotent stem cell-derived cell (hiPSC-EC) model sunitinib-induced vascular dysfunction combined ribosome profiling, we assessed role translational hiPSC-ECs response to We identified staphylococcal...
N6-methyladenosine (m6A), as the most abundant modification of mammalian messenger RNAs, is essential for tissue development and pathogenesis. However, biological significance m6A methylation in cardiac differentiation remains largely unknown. Here, we identify that downregulation demethylase ALKBH5 responsible increase cardiomyocyte fate determination human embryonic stem cells (hESCs) from mesoderm (MESs). In contrast, overexpression remarkably blocks hESCs. Mechanistically, KDM5B RBBP5,...
Abstract Chemotherapy-induced cardiac damage remains a leading cause of death amongst cancer survivors. Anthracycline-induced cardiotoxicity is mediated by severe mitochondrial injury, but little known about the mechanisms which cardiomyocytes adaptively respond to injury. We observed translocation selected tricarboxylic acid (TCA) cycle dehydrogenases nucleus as an adaptive stress response anthracycline-cardiotoxicity in human induced pluripotent stem cell-derived and vivo. The expression...
Abstract Cardiomyocytes differentiated from human‐induced pluripotent stem cells (hiPSCs) hold great potential for therapy of heart diseases. However, the underlying mechanisms its cardiac differentiation have not been fully elucidated. Hippo‐YAP signal pathway plays important roles in cell differentiation, tissue homeostasis, and organ size. Here, we identify role determining fate hiPSCs. We found that hiPSCs were significantly inhibited after treatment with verteporfin (a selective potent...
Iron homeostasis is crucial for a variety of biological processes, but the role iron in pluripotent stem cells (PSCs) remains largely unknown. The present study aimed to determine whether involved maintaining pluripotency human PSCs (hPSCs). We found that intracellular depletion leads rapid downregulation NANOG and dramatic decrease self-renewal hPSCs as well spontaneous nonspecific differentiation. Moreover, long-term can result remarkable cell death via apoptosis necrosis pathways....