A5101571748- Cancer-related molecular mechanisms research
- Endometrial and Cervical Cancer Treatments
- RNA modifications and cancer
- Cancer-related gene regulation
- Endometriosis Research and Treatment
- Cervical Cancer and HPV Research
- Spine and Intervertebral Disc Pathology
- RNA Research and Splicing
- Autophagy in Disease and Therapy
- Cancer Mechanisms and Therapy
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Ovarian cancer diagnosis and treatment
- MicroRNA in disease regulation
- Uterine Myomas and Treatments
- Peroxisome Proliferator-Activated Receptors
- Spinal Fractures and Fixation Techniques
- Epigenetics and DNA Methylation
- RNA Interference and Gene Delivery
- Circular RNAs in diseases
- Plant-Microbe Interactions and Immunity
- Ferroptosis and cancer prognosis
- Cancer Cells and Metastasis
- Nanoparticle-Based Drug Delivery
- Melanoma and MAPK Pathways
Chengdu University of Traditional Chinese Medicine
2025
Harbin Medical University
2020-2024
Lanzhou University
2024
Union Hospital
2015-2022
Huazhong University of Science and Technology
2004-2022
Union Hospital
2021-2022
First Affiliated Hospital of Harbin Medical University
2021
Wuhan Union Hospital
2016-2021
Second Affiliated Hospital of Harbin Medical University
2020
Xian Yang Central Hospital
2020
Abstract ALKBH5 is the main enzyme for m 6 A-based demethylation of RNAs and it has been implicated in many biological pathophysiological processes. Here, we aimed to explore potential involvement osteosarcoma decipher underlying cellular/molecular mechanisms. We discovered downregulated levels demethylase were correlated with increased A methylation cells/tissues compared normal osteoblasts cells/tissues. overexpression significantly suppressed cell growth, migration, invasion, trigged...
Background: Ovarian cancer is a fatal malignant gynecological tumor. stem cells (OCSCs) contribute to resistance chemotherapy. The polycomb group protein enhancer of zeste homolog 2 (EZH2) plays key role in maintaining CSCs. Here, we aimed investigate the specific mechanism by which EZH2 regulates CSCs result chemoresistance and poor prognosis ovarian cancer. Methods: We used nude mouse model obtain cell line enriched for OCSCs, named SK-3rd cells. CRISPR Cas9 endonuclease system was...
Abstract The development of osteoporosis is often accompanied by autophagy disturbance, which also causes new osteoblast defects from bone marrow mesenchymal stem cells (BMSCs). However, the underlying molecular mechanisms are still not fully understood. Methyltransferase-like 14 (METTL14) main enzyme for N6-methyladenosine (m6A), most prevalent internal modification in mammalian mRNAs, and it has been implicated many bioprocesses. Herein, we demonstrate that METTL14 plays a critical role...
This retrospective study aimed to determine the risk factors for venous thromboembolism (VTE) in patients undergoing radical hysterectomy cervical cancer. Data from 366 who underwent surgery between June 2020 and December 2021 were collected medical records. The divided into a thrombosis group nonthrombotic based on presence or absence of VTE. Multivariate analyses revealed that age greater than 45 years, open surgery, an operation time exceeding 4 hours, intraoperative blood transfusion,...
In this study, we aimed to investigate the potential correlation between rs13281615/rs2910164 polymorphisms and prognosis of colon cancer (CC). Taqman was utilized genotype in recruited subjects. Kaplan-Meier survival curves were calculated study prognostic values different genotypes polymorphisms. Real-time polymerase chain reaction, enzyme-linked immunosorbent assay, immunohistochemistry, terminal deoxynucleotidyl transferase dUTP nick-end labeling assays conducted establish a signaling...
Pelvic lymph node metastasis (LNM) is a crucial independent prognostic factor in cervical cancer (CCa) and serves as an indicator for radiation therapy the primary or adjuvant treatment option. However, preoperative diagnosis of LNM remains challenging. Thus, we aimed to identify biomarkers patients with presumed early-stage CCa.The differentially expressed genes (DEGs) between tumours different statuses were identified by using The Cancer Genome Atlas database. Then, univariate Cox...
The present study is a retrospective cohort study. Metabolic syndrome (MetS) clustering of clinical findings that has been shown to increase the risk surgical outcomes. Our aimed evaluate whether MetS was factor for increased perioperative outcomes in patients undergoing posterior lumbar interbody fusion (PLIF).We retrospectively analyzed over 18 years following elective spine from January 2014 December 2018. Emergency procedures, infections, tumor, fracture, and revision surgeries were...
Abstract Background Systematic pelvic lymphadenectomy or whole irradiation is recommended for the patients with stage IB1 cervical cancer. However, precise pattern of lymphatic tumor spread in cancer unknown. In present study we evaluated distribution nodal metastases to explore possibilities tailoring treatment. Methods A total 289 IB1, according FIGO 2009, were retrospectively analyzed. All underwent laparoscopic radical hysterectomy (Querleu and Morrow type C2) systematic without...
Epithelial-mesenchymal transition (EMT) is a critical process in the promotion of epithelial tumor progression and metastasis. The present study aimed to investigate role Ras homolog gene family, member C (RhoC) guanosine triphosphatase (GTPase) transforming growth factor (TGF)-β1 induced EMT. EMT occurred human cervical carcinoma SiHa cells following TGF-β1 stimulation for 4 days, as demonstrated by appearance mesenchymal morphology, reorganization actin cytoskeleton, reduced E-cadherin...
BNIP3 is a proapoptotic protein that mediates apoptosis, necrosis and autophagy. However, the involvement of in cisplatin-induced apoptosis ovarian cancer not clear. In this study, we examined role during cisplatin treatment its correlation with clinical outcomes. We first measured cytotoxicity levels before after exposure for cell lines A2780, SKOV3, OVCAR4, OV2008, ES2 HO8910. was observed to be differentially expressed these lines, induced significant increase A2780 OVCAR4. knockdown...
Melatonin (Mel) has been shown to involve in many essential cell functions via modulating signaling pathways. We for the first time investigated that Mel exerted anti-tumor activities Hodgkin lymphoma (HL) inhibiting proliferation and promoting apoptosis. Further study revealed treatment increased expression of LC3-II decreased p62 proteins with enhanced production autolysosome, indicating it induced activation autophagy. Nevertheless, together autophagy inhibitors 3-MA or CQ exacerbated...
Objectives:We aimed to identify the risk factors associated with pelvic lymph node metastasis (LNM) at each anatomic location in patients stage IB1 cervical cancer.Methods: A primary cohort of 728 cancer who underwent radical hysterectomy and systematic lymphadenectomy were retrospectively studied.All removed nodes (N=20,134) pathologically examined.The for LNM different regions (obturator, internal iliac, external common iliac) evaluated by multivariate logistic regression...
Abstract Osteosarcoma (OS) is the most common primary malignant bone tumour in adolescence. Lately, light‐emitting diodes (LED)‐based therapy has emerged as a new promising approach for several diseases. However, it remains unknown human OS. Here, we found that blue LED irradiation significantly suppressed proliferation, migration and invasion of OS cells, while observed increased ROS production through NADPH oxidase enzymes NOX2 NOX4, well decreased Catalase (CAT) expression levels....