A5011916025- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Cancer, Lipids, and Metabolism
- Cardiac Fibrosis and Remodeling
- Cancer, Hypoxia, and Metabolism
- RNA Research and Splicing
- Phytochemistry and biological activity of medicinal plants
- NF-κB Signaling Pathways
- Advanced biosensing and bioanalysis techniques
- Circadian rhythm and melatonin
- Laser Applications in Dentistry and Medicine
- Signaling Pathways in Disease
- Genetics, Aging, and Longevity in Model Organisms
- Peptidase Inhibition and Analysis
- Cell Adhesion Molecules Research
- Bioinformatics and Genomic Networks
- Autophagy in Disease and Therapy
- Galectins and Cancer Biology
- Inflammasome and immune disorders
- Proteoglycans and glycosaminoglycans research
- Metabolism, Diabetes, and Cancer
- Ultrasound and Cavitation Phenomena
Second Affiliated Hospital of Harbin Medical University
2017-2025
Harbin Medical University
2015-2025
Second Affiliated Hospital of Zhejiang University
2023
First Hospital of Jilin University
2020-2022
Jilin University
2020-2022
Zhuzhou Central Hospital
2021
Central South University
2021
Tianjin University of Traditional Chinese Medicine
2021
University Medical Center Groningen
2017
University of Groningen
2017
Cardiac interstitial fibrosis is a major cause of the deteriorated performance heart in patients with chronic myocardial infarction. MicroRNAs (miRs) have recently been proven to be novel class regulators cardiovascular diseases, including those associated cardiac fibrosis. This study aimed explore role miR-101 and underlying mechanisms.Four weeks after coronary artery ligation rats, expression miR-101a miR-101b (miR-101a/b) peri-infarct area was decreased. Treatment cultured rat neonatal...
Bone marrow-derived mesenchymal stem cells (BMSCs) have been suggested to possess the capacity differentiate into different cell lineages. Maintaining a balanced differentiation program is crucial bone microenvironment and development. MicroRNAs (miRNAs) played critical role in regulating of BMSCs particular lineage. However, miR-149-3p adipogenic osteogenic has not extensively discovered. In this study, we aimed detect expression levels during investigate whether participated lineage choice...
Abstract Bone marrow mesenchymal stem cells ( BMSC s) are an expandable population of which can differentiate into osteoblasts, chondrocytes and adipocytes. Dysfunction s in response to pathological stimuli contributes bone diseases. Melatonin, a hormone secreted from pineal gland, has been proved be important mediator formation mineralization. The aim this study was investigate whether melatonin protected against iron overload‐induced dysfunction its underlying mechanisms. Here, we found...
Bone marrow-derived mesenchymal stem cells (BMSCs) have the potential to differentiate into osteoblasts or adipocytes, and shift between osteogenic adipogenic differentiation determines bone mass. The aim of this study was identify whether lncRNAs are involved in commitment BMSCs during osteoporosis. Here, we found ORLNC1, a functionally undefined lncRNA that is highly conserved, which exhibited markedly higher expression levels BMSCs, tissue, serum OVX-induced osteoporotic mice than...
Cardiac hypertrophy is a key factor driving heart failure (HF), yet its pathogenesis remains incompletely elucidated. Mettl1-catalyzed RNA N7-methylguanosine (m7G) modification has been implicated in ischemic cardiac injury and fibrosis. This study aims to elucidate the role of Mettl1 mechanism underlying non-ischemic HF. It found that upregulated human failing hearts hypertrophic murine following transverse aortic constriction (TAC) Angiotensin II (Ang II) infusion. YY1 acts as...
Lung cancer is one of the leading causes death worldwide. microRNAs have been shown to be a novel class regulators in lung cancer. Here, we explored role miR‐153 pathogenesis and its therapeutic potential. was significantly decreased tissues than adjacent tissues. The protein mRNA levels kinase B (AKT), which were promote tumor growth, both increased Overexpression inhibited AKT expression, abrogated by co‐transfection AMO‐153, specific inhibitor miR‐153. Luciferase assay showed that...
Oxidative stress plays an important role in cardiovascular diseases. Studies have shown that miR-1 the regulation of cardiomyocyte apoptosis, which can be result oxidative stress. This study was designed to determine whether increased levels lead alterations expression proteins related stress, could contribute heart dysfunction. We compared cardiac function wild-type (WT) and transgene (miR-1/Tg) C57BL/6 mice (n ≥ 10/group). Echocardiography showed stroke volume (SV), ejection fraction (EF),...
Acute myocardial infarction (AMI) is the leading cause of sudden death worldwide. MicroRNA-155 (miR-155) has been reported to target antiapoptotic genes in various diseases models, but functional role miR-155 response MI injury needs further investigations. This study investigated ischemia injury. TUNEL and flow cytometry were performed measure cell apoptosis. Western blot analysis was employed detect protein expressions Bcl-2, XIAP, Bax, caspase-3. qRT-PCR used quantify miRNA levels. We...
Abstract Non-coding RNAs participate in many cardiac pathophysiological processes, including myocardial infarction (MI). Here we showed the interplay between long non-coding RNA taurine-upregulated gene 1 (lncR-TUG1), miR-9a-5p (miR-9) and Krüppel-like factor 5 (KLF5). LncR-TUG1 was upregulated ischemic heart cultured cardiomyocytes exposed to H 2 O . Knockdown of lncR-TUG1 markedly ameliorated impaired function MI mice. Further study that acted as a competitive endogenous miR-9, silencing...
Background . Aloe emodin (AE) is a lipid-lowering agent, which could be used to treat hyperlipidemia, thereby reducing the risk of cardiovascular disease. Recent evidence suggests that hyperlipidemia associated with many cardiac pathological alterations and might worsen myocardial damages. Purpose The purpose this study evaluate potential roles mechanisms AE in hyperlipidemia-induced oxidative stress inflammation heart. Study Design We established model rats cells then administered observed...
Background: Chronic high-fat diets (HFDs) lead to an imbalance of calcium homeostasis in cardiomyocytes, which contributes the development myocardial ischemia-reperfusion injury, dilated cardiomyopathy, and other cardiovascular diseases. Aloe-emodin (AE) is anthraquinone component isolated from aloe, rhubarb, cassia seed, having protective, hepatoprotective, anti-inflammatory, pharmacological effects. Objective: This study aimed explore specific role AE obesity/hyperlipidemia-induced...
// Liuyi Dong 1, * , Ye Yuan 2, Cynthia Opansky 1 Yiliang Chen Irene Aguilera-Barrantes 3 Shiyong Wu 2 Rong Qi Cao 4 Yee Chung Cheng 5 Daisy Sahoo Roy L. Silverstein Bin Ren Blood Research Institute, Center of Wisconsin, Milwaukee, USA Edison Biotechnology Institute and Department Chemistry Biochemistry, Ohio University, Athens, Ohio, Pathology, Medical College Diagnostic Radiology Nuclear Medicine, University Maryland Center, Baltimore, Maryland, These authors contributed equally to this...
Therapeutic efficiency of cardiac progenitor cells (CPCs) transplantation is limited by its low survival and retention in infarcted myocardium. Autophagy plays a critical role regulating cell death apoptosis, but the microRNAs (miRNAs) oxidative stress-induced autophagy CPCs remains unclear. This study aimed to explore if miRNAs mediate c-kit+ CPCs. We found that silencing miR-143 promoted response H2O2, protective effect inhibitor was abrogated 3-methyladenine (3-MA). Furthermore,...
Considering complicated microRNA (miRNA) biogenesis and action mechanisms, it was thought so high energy-consuming for a cell to afford simultaneous over-expression of many miRNAs. Thus prompts that an alternative miRNA regulation pattern on protein-encoding genes must exist, which has characteristics energy-saving precise protein output. In this study, expression tendency proteins encoded by miRNAs' target evaluated in human organ scale, followed quantitative assessment synergism....