A5002684638- Cardiac Fibrosis and Remodeling
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Phytochemistry and biological activity of medicinal plants
- Atrial Fibrillation Management and Outcomes
- MicroRNA in disease regulation
- Cardiac electrophysiology and arrhythmias
- Autophagy in Disease and Therapy
- Ion Channels and Receptors
- Cardiac Ischemia and Reperfusion
- Cardiovascular Function and Risk Factors
- Nitric Oxide and Endothelin Effects
- Neurological Disease Mechanisms and Treatments
- Biomarkers in Disease Mechanisms
- Ginseng Biological Effects and Applications
- RNA regulation and disease
- Sirtuins and Resveratrol in Medicine
- Tracheal and airway disorders
- Advanced Glycation End Products research
- Antioxidant Activity and Oxidative Stress
- Signaling Pathways in Disease
- Phytochemicals and Antioxidant Activities
- Foreign Body Medical Cases
Harbin Medical University
2018-2025
Second Affiliated Hospital of Harbin Medical University
2018-2025
Zhengzhou Central Hospital
2020-2024
Jiangsu Provincial Center for Disease Control and Prevention
2024
Southeast University
2024
Henan Provincial People's Hospital
2020-2024
Second Affiliated Hospital of Xi'an Jiaotong University
2015-2023
Zhejiang University
2023
First Affiliated Hospital Zhejiang University
2016-2023
Fu Wai Hospital
2023
Abstract The timely regulation of inflammatory M1 macrophage polarization toward regenerative M2 macrophages suggests the possibility immunotherapy after myocardial infarction (MI). C1q/TNF‐related protein‐9 (CTRP9) has anti‐inflammatory effects and can ameliorate heart function in mice long‐term infarction. role CTRP9 remains completely unclear. This study determined whether preserve post‐MI early cardiac through polarization. In present study, an adenovirus‐delivered supplement promoted at...
Acute myocardial infarction (AMI) is the leading cause of sudden death worldwide. MicroRNA-155 (miR-155) has been reported to target antiapoptotic genes in various diseases models, but functional role miR-155 response MI injury needs further investigations. This study investigated ischemia injury. TUNEL and flow cytometry were performed measure cell apoptosis. Western blot analysis was employed detect protein expressions Bcl-2, XIAP, Bax, caspase-3. qRT-PCR used quantify miRNA levels. We...
Abstract Non-coding RNAs participate in many cardiac pathophysiological processes, including myocardial infarction (MI). Here we showed the interplay between long non-coding RNA taurine-upregulated gene 1 (lncR-TUG1), miR-9a-5p (miR-9) and Krüppel-like factor 5 (KLF5). LncR-TUG1 was upregulated ischemic heart cultured cardiomyocytes exposed to H 2 O . Knockdown of lncR-TUG1 markedly ameliorated impaired function MI mice. Further study that acted as a competitive endogenous miR-9, silencing...
Background . Aloe emodin (AE) is a lipid-lowering agent, which could be used to treat hyperlipidemia, thereby reducing the risk of cardiovascular disease. Recent evidence suggests that hyperlipidemia associated with many cardiac pathological alterations and might worsen myocardial damages. Purpose The purpose this study evaluate potential roles mechanisms AE in hyperlipidemia-induced oxidative stress inflammation heart. Study Design We established model rats cells then administered observed...
Background/Aims: MicroRNAs play an important role in regulating myocardial infarction (MI)-induced cardiac injury. MicroRNA-124 (miR-124) plays a vital cellular proliferation, differentiation and apoptosis. Although the alteration of miR-124 was confirmed peripheral blood MI patients, little is known regarding biological functions cardiomyocytes. This study designed to explore its underlying mechanisms. Methods: Real-time PCR used quantify microRNAs levels. TUNEL Flow cytometry were...
Abstract Background Flexible fiberoptic bronchoscopy is a rapid, cost effective and safe procedure. Aim To analyze demographic information endoscopic findings in adult patients with airway foreign body aspiration its removal. Methods Fifty-seven adults (40 males, 17 females; average age 40 years old) were analyzed. Cough (37, 65%) was the most common clinical presentation. The bone followed by dental prosthesis food debris. Results In current study, 42 out of 57 (74%) bodies successfully...
The multimodal sensory channel transient receptor potential vanilloid-3 (TRPV3) is expressed in epidermal keratinocytes and implicated chronic pruritus, allergy, inflammation-related skin disorders. Gain-of-function mutations of TRPV3 cause hair growth disorders mice Olmsted syndrome humans. Nevertheless, whether how could be therapeutically targeted remains to elucidated. We here report that mouse human by the clinical medication dyclonine exerts a potent inhibitory effect. Accordingly,...
Background: Chronic high-fat diets (HFDs) lead to an imbalance of calcium homeostasis in cardiomyocytes, which contributes the development myocardial ischemia-reperfusion injury, dilated cardiomyopathy, and other cardiovascular diseases. Aloe-emodin (AE) is anthraquinone component isolated from aloe, rhubarb, cassia seed, having protective, hepatoprotective, anti-inflammatory, pharmacological effects. Objective: This study aimed explore specific role AE obesity/hyperlipidemia-induced...
Sensitive detection of Porcine circovirus-2 (PCV-2) is very important for surveillance postweaning multisystemic wasting syndrome. Droplet digital polymerase chain reaction (ddPCR) novel PCR method that can achieve high precision. Our study aimed to develop a sensitive assay utilizing ddPCR detect PCV-2. Specificity the was confirmed by failure amplification DNA other relevant viruses. The limit 25 copies/μL, 4-fold greater sensitivity than TaqMan real-time PCR. Both methods showed degree...
Aujeszky's disease, caused by pseudorabies virus (PRV), has damaged the economy of Chinese swine industry. A large number PRV gene-deleted vaccines have been constructed based on deletion glycoprotein E ( gE) gene combined with other virulence-related deletions, such as thymidine kinase TK), whereas wild-type strains contain an intact gE gene. We developed a sensitive duplex droplet digital PCR (ddPCR) assay to rapidly detect isolates and viral vaccines. compared this TaqMan real-time (qPCR)...
The left bundle branch block (LBBB) is associated with ventricular septal mid-wall fibrosis (SMF) in patients dilated cardiomyopathy (DCM). However, whether LBBB also SMF preserved ejection fraction (LVEF) remains unclear. We performed a retrospective study of 210 LVEF (male, n = 116; female, 94; mean age, 44 ± 17 years). was defined as QRS duration ≥140 ms for men or ≥ 130 women, QS rS V1-V2, mid-QRS notching slurring at least two leads (V1, V2, V5, V6, I, and aVL). determined by late...
The aim of this study is to report our experience in the diagnosis and treatment tracheobronchial foreign bodies (TFBs). We retrospectively reviewed medical records 2,000 TFB patients (1,260 males 740 females) who were treated between January 2010 December 2013. Chest radiography computed tomography performed diagnose TFBs. location type (FBs), anesthesia methods, outcomes complications analyzed. Overall, 72.5% with aged 1 years 3 years. Plant-based FBs are most common FB type, accounting...
Decidualization is a critical step during embryo implantation that characterized by the differentiation of endometrial stromal cells (ESC) into decidua cells. However, mechanism remains largely unknown. Previously, it has been shown null function homeo box A10 (HOXA10) causes defects in both and decidualization, suggesting HOXA10 signalling pathway likely to be involved uterine decidualization. In present study, we determined expression subcellular distribution its downstream molecule, p57,...
Abstract: This prospective study was conducted to evaluate the efficacy of sea buckthorn oil patches in treating traumatic tympanic membrane (TM) perforations. We enrolled 370 patients with TM perforations different sizes. These were randomly assigned control group and treatment group. In group, a sterile cotton patch used cover treated patch. The healing rate time compared between two groups. found that overall significantly higher than For middle large perforations, led significant...