Generation of cGMP via NO-sensitive soluble guanylyl cyclase (sGC) has been implicated in the regulation renal functions. Chronic kidney disease (CKD) is associated with decreased NO bioavailability, increased oxidative stress and oxidation sGC to its haem-free form, apo-sGC. Apo-sGC cannot be activated by NO, resulting impaired signalling that chronic progression. We hypothesised activators, which activate apo-sGC independently increase production under conditions stress, thereby improving...

ABSTRACT Acquired reactive proliferating collagen (ARPC), usually associated with systemic diseases, is a rare skin disease characterized by the elimination of altered dermal through epidermis. Here, we report two cases ARPC in maintenance hemodialysis patients, one which combined type 2 diabetes, chronic renal failure, and hypertension other failure hypothyroidism. Two patients were treated oral thalidomide ebastine, local application fluticasone propionate cream, enhanced dialysis. After...

Background Hypertensive myocardial fibrosis (MF) is characterized by excessive deposition of extracellular matrix and cardiac fibroblast proliferation, which can lead to heart failure, malignant arrhythmia, sudden death. In recent years, with the deepening research, microRNAs have been found an important role in blood pressure control maintaining normal ventricular structure function. Methods Results this study, we first documented downregulation microRNA-26a (miR-26a) plasma myocardium...

Human umbilical cord blood-derived mesenchymal stem cells (hUC-MSCs) have been widely used in tissue engineering. The aim of this study is to evaluate the ability poly (3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) scaffolds coated with polyhydroxyalkanoate binding protein fused arginyl-glycyl-aspartic acid (PhaP-RGD) promote proliferation and chondrogenic differentiation hUC-MSCs seeded on them. PhaP-RGD fusion was expressed by Escherichia coli. PHBHHx films were physiochemical...

The aim of this study is to report our experience in the diagnosis and treatment tracheobronchial foreign bodies (TFBs). We retrospectively reviewed medical records 2,000 TFB patients (1,260 males 740 females) who were treated between January 2010 December 2013. Chest radiography computed tomography performed diagnose TFBs. location type (FBs), anesthesia methods, outcomes complications analyzed. Overall, 72.5% with aged 1 years 3 years. Plant-based FBs are most common FB type, accounting...

<b><i>Objective:</i></b> This study aimed to detect the genotype distributions and allele frequencies of methylenetetrahydrofolate reductase (MTHFR) C677T, A1298C methionine synthase (MTRR) A66G polymorphisms pregnant women in Jiaodong region China, investigate whether folic acid supplementation affect pregnancy complications. <b><i>Setting:</i></b> A total 7,812 from Shandong province China. <b><i>Methods:</i></b> By...

Obstructive sleep apnea syndrome (OSAS) is related to hypertension. Vascular remodeling both the pathogenesis and structural change basis of OSAS-related Exploring miRNA functioning in hypertension may offer novel diagnostic therapeutic targets for controlling hypertension-associated cardiovascular diseases. However, role miR-199a-5p has not been demonstrated yet.In this study, we investigated HIF-1α by performing vitro cell experiments vivo animal experiments. Rat aortic smooth muscle cells...

Objective: After acute myocardial infarction (AMI), the loss of cardiomyocytes and dysregulation extracellular matrix homeostasis results in impaired cardiac function eventually heart failure. Cardiac patches have emerged as a potential therapeutic strategy for AMI. In this study, we fabricated produced reduced graphene oxide (rGO)/silk fibroin-modified nanofibrous biomaterials patch to repair rat tissue after AMI investigated role rGO/silk on reducing fibrosis improving infarcted rats....

Objective To investigate the involvement of microRNAs (miRNAs) in pathogenesis obstructive sleep apnea-hypopnea syndrome (OSAHS). Methods In this study, we investigated miRNA profiles upper airway (UA) skeletal muscles four patients with OSAHS and matched controls using miRCURY array. another cohort 12 cases 7 controls, mRNA expression levels interleukin (IL)-6 Lin-28 homolog A (Lin28A), targets downregulated let-7 family members, were measured by real-time quantitative-PCR. The potential...

Abstract Background The SYNTAX score affects clinical outcomes in early studies. However, the prognostic value of Score for long-term and differences by risk stratification prognosis between medical therapy percutaneous coronary intervention (PCI) patients with unstable angina pectoris (UAP) are not well known era new generation drug-eluting stents medication. Methods In this single-centre retrospective study, a total 2364 UAP from January 2014 to June 2017 at Beijing Friendship Hospital...

Abstract Objective To explore the effects of Draf1–3 on frontal sinus airflow and irrigation in people with different development Methods The distribution recess cells were evaluated by CT scan 150 adults (300 sides). changes into after Draf analyzed Fluent software under a steady state quiet inspiratory state. Nasal well-developed was simulated using 120 mL saline at rate 12 mL/s position 45° to observe transient flow distribution. Results moderately developed type most common. patterns...

Hypertensive vascular remodelling is responsible for end-organ damage and the result of increased extracellular matrix accumulation excessive smooth muscle cell (VSMC) proliferation. MicroRNA-26a (miR-26a), a non-coding small RNA, involved in several cardiovascular diseases. We aimed to validate effect mechanisms miR-26a hypertensive remodelling.Male spontaneously rats (SHRs) were injected intravenously with recombinant adeno-associated virus-miR-26a. Samples thoracic aorta examined...

To compare the clinical effects of modified uvulopalatopharyngoplasty (UPPP) with low-temperature plasma selective nasal cavity vasodilatation tongue volume reduction for obstructive sleep apnea/hypopnea syndrome (OSAHS).A retrospective analysis based on 156 patients serious OSAHS was used evaluation. These were divided into 2 groups according to surgery methods 1:1.s. The in observation group accepted UPPP and root basis fully preparation surgery, while control normal treatment. clinic...

Abstract Invasive lobular breast cancer (ILC) is an understudied subtype of characterized by late recurrence, metastasis to serosal surfaces including the peritoneum, and poor long-term outcomes. Lobular carcinoma in situ (LCIS) a non-obligate precursor ILC but associated with 30% increased risk developing ILC. Therefore, understanding underlying changes that occur invasive cells as well their tumor microenvironment (TME) during transition from LCIS critical for development novel therapeutic...

This study aims to summarize the clinical characteristics of skull base osteoradionecrosis (ORN) with internal carotid artery (ICA) involvement and distill key surgical techniques that can enhance protective measures for ICA. We conducted a retrospective, observational over six-year period from February 2017 May 2023. included patients who were diagnosed invasion collected their demographic information, pathology results, complication rates, ect. The goal was alleviated rate after surgery...

To detect the different morphologic features, developmental regulation, potential of proliferation and differentiation neonatal rat cochlea progenitor spheres. We isolated sensory epithelium cells from rats cultured them in nonadherent conditions to acquire Then we observed diameter compositional change cell colonies distinct sphere types on day 3, 6, 9 12, summarized regularity development their conversion. also detected proliferative activity spheres by immunohistochemical staining Abcg2,...

OBJECTIVE To investigate the optimal operative approach for complicated anal fistula. METHODS One hundred and ninety-two cases with fistula were randomly divided into minimally invasive operation group (through spatium intermuscular of sphincter) resection group. The time, bleeding time during after operation, pain lasting healing incision, area scar, malformation function post recurrence observed compared between two groups. RESULTS Compared to those group, was (36.5+/- 15.3)min, (2.0+/-...

To investigate the prevalence of coronary artery disease and characteristics in patients with obstructive sleep apnoea.The prospective study was conducted at Affiliated Huai'an Hospital Xuzhou Medical University, Huai'an, China, from January, 2012, to June, 2015, comprised consecutive diagnosed apnoea. High-resolution 320-slice computed tomography performed all patients. Data evaluated for presence lumen narrowing. Demographic, clinical, laboratory, echocardiographic were carefully recorded....

目的 探讨以改良鼻丘径路额窦开放为主的鼻内镜修正性手术治疗难治性鼻－鼻窦炎(RRS)的临床疗效。 方法 回顾分析淮安市第二人民医院耳鼻咽喉科，2012年2月–2014年8月收治的156例既往多次手术及药物治疗无效，并经CT及鼻内镜检查确诊的RRS患者的临床资料。根据手术方法的不同分为观察组和对照组，每组78例患者。观察组行以改良鼻丘径路额窦开放为主的鼻内镜修正性手术，联合中鼻甲切除、充分围手术期处理、术后严格遵医嘱随访等系统治疗；对照组常规手术方法治疗。比较2组临床疗效、手术并发症及术后复发情况等指标。 结果 所有患者随访6个月后，观察组有效率为91.03%(71/78)，对照组为71.79%(56/78)，差异有统计学意义(χ2＝9.530, P<0.05)；观察组并发症发生率(7.69%，6/78)和复发率(3.85%，3/78)均低于对照组(17.95%，14/78；12.82%，10/78)，差异均有统计学意义(χ2＝3.981，4.372,...