A5115595840- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA Research and Splicing
- Catalytic Processes in Materials Science
- Mesenchymal stem cell research
- Nerve injury and regeneration
- Osteoarthritis Treatment and Mechanisms
- Epigenetics and DNA Methylation
- Protist diversity and phylogeny
- Cell Adhesion Molecules Research
- Supercapacitor Materials and Fabrication
- Spinal Cord Injury Research
- NF-κB Signaling Pathways
- Genetic and Kidney Cyst Diseases
- Bone and Joint Diseases
- Aerogels and thermal insulation
- Advanced Wireless Communication Techniques
- Peptidase Inhibition and Analysis
- Immune Response and Inflammation
- Graphene and Nanomaterials Applications
- Cell death mechanisms and regulation
- Wireless Communication Networks Research
Zhejiang Sci-Tech University
2024-2025
Shanghai Ninth People's Hospital
2020-2025
Shanghai Jiao Tong University
2019-2025
Peking University Cancer Hospital
2024-2025
Peking University
2024-2025
Shandong University of Traditional Chinese Medicine
2025
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2025
Shinva (China)
2024-2025
Ingenierie des Materiaux polymeres
2025
Interface (United Kingdom)
2025
Methyltransferase-like 3 (METTL3) is the main enzyme for N6-methyladenosine (m6A)-based methylation of RNAs and it has been implicated in many biological pathophysiological processes. In this study, we aimed to explore potential involvement METTL3 osteoblast differentiation decipher underlying cellular molecular mechanisms. We demonstrated that downregulated human osteoporosis ovariectomized (OVX) mouse model, as well during osteogenic differentiation. Silence by short interfering RNA...
Abstract The development of osteoporosis is often accompanied by autophagy disturbance, which also causes new osteoblast defects from bone marrow mesenchymal stem cells (BMSCs). However, the underlying molecular mechanisms are still not fully understood. Methyltransferase-like 14 (METTL14) main enzyme for N6-methyladenosine (m6A), most prevalent internal modification in mammalian mRNAs, and it has been implicated many bioprocesses. Herein, we demonstrate that METTL14 plays a critical role...
The inflammatory cascade after spinal cord injury (SCI) causes necrotizing apoptosis of local stem cells, which limits nerve regeneration. Therefore, coordinating the immune response and neural cell (NSC) functions is key to promoting recovery central nervous system function. In this study, a hydrogel "perfusion" electrospinning technology are integrated, "concrete" composite support for repair injuries built. hydrogel's hydrophilic properties activate macrophage integrin receptors mediate...
Both osteoblasts and preosteoclasts contribute to the coupling of osteogenesis angiogenesis, regulating bone regeneration. Astragaloside IV (AS-IV), a glycoside cycloartane-type triterpene derived from Chinese herb Astragalus membranaceus, exhibits various biological activities, including stimulating angiogenesis attenuating ischemic-hypoxic injury. However, effects underlying mechanisms AS-IV in osteogenesis, osteoclastogenesis, regeneration remain poorly understood. In present study, we...
Graphical Abstract Schematic diagram of tumor-derived exosomes induced organotropism and immunosuppression.
Abstract Objectives Chordoma is a rare malignant bone tumour arising from notochordal remnants. Long non‐coding RNA LOC 554202, as the host gene of miR‐31, contributes to various cancer developments. However, little known about biological function 554202 in chordoma. Here, relationship between Lnc miR‐31 and EZH 2 was elucidated Materials methods The levels 554402, 2, RNF 144B, epithelial‐mesenchymal transition ( EMT ) markers were measured chordoma tissues cell lines via quantitative...
In differentiated human cells, primary cilia fulfill essential functions in converting mechanical or chemical stimuli into intracellular signals. Formation and maintenance of require multiple associated with the centriole-derived basal body, from which axonemal microtubules grow assembles a gate to maintain specific ciliary proteome. Here we characterize function novel centriolar satellite protein, synovial sarcoma X breakpoint-interacting protein 2 (SSX2IP), assembly cilia. We show that...
The vision-based fruit recognition and localization system is the basis for operation of agricultural harvesting robots. However, there are many complicating factors in fruit-growing environment, such as changes light intensity, overlap between fruits, shading branches leaves, which increase difficulty robot vision localization. existing detection models often constrained by high complexity slow inference speed, do not meet real-time requirements Here, an apple-object method proposed to...
Abstract TGFβ1 signaling is a critical driver of collagen accumulation in pulmonary fibrotic diseases and well-characterized regulator cancer associated fibroblasts (CAF) activation lung cancer. Myofibroblasts induced by other factors are key players the pathogenesis fibrosis tumor. Tremendous attention has been gained to targeting myofibroblasts order inhibit progression myofibroblast-induced tumor metastasis. Here we determined therapeutic efficacy simultaneously PI3K HDAC pathways CAF...
Abstract This study examines the biocompatibility, osteogenic potential, and effectiveness of polyether ether ketone (PEEK) composites for treating osteonecrosis, seeking to establish a theoretical basis clinical application. A range PEEK composite materials, including sulfonated (SPEEK), polydopamine-sulfonated (SPEEK-PDA), bone-forming peptide-poly-dopamine-sulfonated (SPEEK-PDA-BFP), vascular endothelial growth factor-poly-dopamine-sulfonated (SPEEK-PDA-VEGF), were constructed by...
Miniature scroll compressors are the key devices for portable oxygen generation, micro-refrigeration, and surgical applications, etc. The plate working as core component, directly determines compressor’s sizes performances. However, limited research on it constrains development of high-end miniature compressors. In this study, traditional involute S0 serves baseline constructing two optimized plates S1 S2 with varied base circle. is designed to increase flow rate while maintaining same size...
Keloids are benign fibroproliferative disorders characterized by excessive collagen deposition and inflammation that extend beyond the original wound boundaries. IL-33 is an alarmin cytokine released upon cellular damage or stress. Dysregulation of in epidermal keratinocytes compromises skin barrier triggers chronic inflammation. In this study, we first noticed increased expression keloid epidermis through histological staining. Then, receptor (ST2) lymphocytes infiltrating superficial...