A5050725585- Cancer-related molecular mechanisms research
- Immunotherapy and Immune Responses
- Rheumatoid Arthritis Research and Therapies
- Mesenchymal stem cell research
- Spondyloarthritis Studies and Treatments
- Autoimmune and Inflammatory Disorders Research
- Berberine and alkaloids research
- Pharmacological Effects of Natural Compounds
- Immune cells in cancer
- Curcumin's Biomedical Applications
- Periodontal Regeneration and Treatments
- Bone and Joint Diseases
- Cytokine Signaling Pathways and Interactions
- Extracellular vesicles in disease
- T-cell and B-cell Immunology
- Signaling Pathways in Disease
- MicroRNA in disease regulation
- PARP inhibition in cancer therapy
- Medicinal Plant Pharmacodynamics Research
- Osteoarthritis Treatment and Mechanisms
- Fibroblast Growth Factor Research
- Cancer Research and Treatments
- Immune Cell Function and Interaction
- Bone Metabolism and Diseases
- Cancer Immunotherapy and Biomarkers
Shanghai University of Traditional Chinese Medicine
2024-2025
Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine
2023-2024
Harbin Medical University
2016-2020
First Affiliated Hospital of Harbin Medical University
2016-2020
Osteosarcoma is one of the most devastating cancers with associated poor prognosis. Chronic bone inflammation frequently predisposes to tumorigenesis and progression osteosarcoma. In tumor inflammatory microenvironment, caspase-1 its processed cytokines such as interleukin 1β (IL-1β) play an important role in occurrence development cancer. Berberine isoquinoline alkaloid extracted from dry root Coptidis Rhizoma, which has been found exhibit significant anticancer effects on a wide spectrum...
The aim of this study is to evaluate the effect transient receptor potential vanilloid 4 (TRPV4) on osteoclast differentiation and osteoporosis, investigate underlying mechanism. results showed that TRPV4 expression intracellular Ca2+ concentration were significantly upregulated in macrophage colony-stimulating factor (M-CSF)-stimulated activator nuclear κΒ ligand (RANKL)-stimulated RAW264.7 cells. Furthermore, overexpression further increased M-CSF- RANKL-induced number tartrate-resistant...
Fibroblast-like synoviocytes (FLSs) contribute to inflammation and joint damage in rheumatoid arthritis (RA). However, the regulatory mechanisms of FLSs relapse remission RA remain unknown. Identifying FLS heterogeneity their underlying pathogenic roles may lead discovering novel disease-modifying antirheumatic drugs.
The present study aimed to investigate the articular cartilage and chondrocytes of dexamethasone (DXM)-induced injuries in rats response treatment with icariin, as well implicated molecular mechanism. Effects icariin on bone metabolism experimental were investigated. Subsequently, assessed dysregulated microRNA (miRNA) rats, validated significant miRNA their targets. Finally, effects mechanism explored. Quantitative polymerase chain reaction demonstrated that significantly reversed...
Platelet lysate (PL) has been shown to induce chondrogenic differentiation of human umbilical cord‐derived mesenchymal stem cells (hUCMSCs). However, the underlying mechanism is still not clear. The aim this study was investigate whether long noncoding RNA H19 involved in process. hUCMSCs were isolated, identified and cultured 5% PL‐supplemented medium. Chondrogenic assessed by Alcian blue staining. expressions H19, miR‐29b‐3p, SRY‐related high‐mobility‐group box 9 (SOX9), collagen II...
Abstract Aryl hydrocarbon receptor (AhR) is a key transcription factor that modulates the differentiation of T helper 17 (Th17) cells. How AhR regulated at post-translational level in Th17 cells remains largely unclear. Here, we identify USP21 as newly defined deubiquitinase AhR. We demonstrate interacts with and stabilizes by removing K48-linked polyubiquitin chains from Interestingly, inhibits transcriptional activity deubiquitinating-dependent manner. deubiquitinates K432 residue,...
Background: Rheumatoid arthritis (RA) joint inflammation severely affects function and quality of life in patients leads to deformities limb disability. The non-steroidal anti-inflammatory drugs used the treatment RA do not fully control progression bone destruction have notable adverse reactions. Traditional Chinese medicine formula JuanBiQiangGu Granules (JBQG) are commonly for delay destruction, but has been evaluated through high-quality clinical studies. There is a pressing need...
Background: Rheumatoid arthritis (RA) is a chronic autoimmune disorder marked by persistent inflammation and joint degeneration. Existing treatments for RA remain limited. JuanBiQiangGu (JBQG), traditional Chinese herbal formulation, has been proposed as potential therapeutic RA. However, its active constituents their roles in mitigating warrant further examination.Methods: Components within JBQG target genes were identified through liquid chromatography-mass spectrometry comprehensive gene...