A5102865632- Radiomics and Machine Learning in Medical Imaging
- AI in cancer detection
- Gastric Cancer Management and Outcomes
- CRISPR and Genetic Engineering
- Thyroid Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Medical Imaging Techniques and Applications
- Cancer-related gene regulation
- Lung Cancer Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- Cancer-related molecular mechanisms research
- Metastasis and carcinoma case studies
- Cancer Immunotherapy and Biomarkers
- Head and Neck Cancer Studies
- RNA and protein synthesis mechanisms
- Migraine and Headache Studies
- Gastrointestinal Tumor Research and Treatment
- Olfactory and Sensory Function Studies
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Lung Cancer Treatments and Mutations
- Bacterial Genetics and Biotechnology
- Heavy Metal Exposure and Toxicity
- Advanced Drug Delivery Systems
- MicroRNA in disease regulation
Hebei Agricultural University
2024-2025
Romax Technology (United Kingdom)
2025
Wenzhou Medical University
2019-2025
LabCorp (United States)
2025
Qilu University of Technology
2024
Shandong Academy of Sciences
2024
University of Notre Dame
2023-2024
Binzhou University
2024
Shanghai Jiao Tong University
2020-2024
Tianjin Medical University Cancer Institute and Hospital
2020-2024
Background: Cancer stem cells (CSCs) are highly tumorigenic, chemotherapy-resistant, tumor growth-sustaining, and implicated in recurrence.Previous studies have shown that lysine-specific histone demethylase 1A (KDM1A) is expressed several human malignancies CSCs.However, the role of KDM1A CSCs therapeutic potential inhibitors for treatment advanced thyroid cancer poorly understood.Methods: Firstly, was identified as an important epigenetic modifier maintained stemness through a mini...
Abstract Homologous recombination-mediated genome engineering has been broadly applied in prokaryotes with high efficiency and accuracy. However, this method is limited realizing larger-scale editing numerous genes or large DNA fragments because of the relatively complicated procedure for template construction. Here, we describe a CRISPR-Cas9 assisted non-homologous end-joining (CA-NHEJ) strategy rapid efficient inactivation bacterial gene (s) homologous recombination-independent manner...
Abstract Background Benzo[a]pyrene (B[a]P), a carcinogen pollutant produced by combustion processes, is present in the western diet with grilled meats. Chronic exposure of B[a]P hepatocellular carcinoma (HCC) cells promotes metastasis rather than primary proliferation, implying an unknown mechanism B[a]P‐induced malignancy. Given that exosomes carry bioactive molecules to distant sites, we investigated whether and how mediate cancer‐stroma communications for toxicologically associated...
The objective of this article is to evaluate electrically evoked thresholds for cortical spreading depression (CSD) and stress-induced activation trigeminal afferents in a rat model medication-overuse headache (MOH).Sumatriptan or saline was delivered subcutaneously by osmotic minipump six days Sprague-Dawley rats. Two weeks after pump removal, animals were anesthetized recording/stimulating electrodes implanted. pretreated with vehicle topiramate followed graded electrical stimulation...
Abstract Direct optimization of the metabolic pathways on chromosome requires tools that can fine tune overexpression a desired gene or optimize combination multiple genes. Although plasmid-dependent has been used for this task, fundamental issues concerning its genetic stability and operational repeatability have not addressed. Here, we describe rapid reliable strategy chromosomal integration gene(s) with copies (CIGMC), which uses flippase from yeast 2-μm plasmid. Using green fluorescence...
Graphical Abstract Schematic diagram of tumor-derived exosomes induced organotropism and immunosuppression.
Background The clinical benefits of antiprogrammed cell death protein 1 (PD-1) therapy are compromised by resistance in immunologically cold tumors. Convergence immunotherapy and bioengineering is potential to overcome the resistance. Mesoporous silica nanoparticles (MSNs) considered most promising inorganic biological nanomaterials for transformation, however, fundamental influence MSNs on unclear. In this study, we aimed investigate role tumor resensitization explore feasibility combined...
Abstract The oxygenic photosynthetic bacterium Synechocystis sp. PCC 6803 (S6803) is a model cyanobacterium widely used for fundamental research and biotechnology applications. Due to its polyploidy, existing methods genome engineering of S6803 require multiple rounds selection modify all copies, which time‐consuming inefficient. In this study, we engineered the Cas9 tool one‐step, segregation‐free engineering. We further our delete three seven native plasmids. Our results show that...
Abstract Modern diets, which often feature high levels of fat and charcoal-grilled meat, contribute to the pathogenesis obesity non-alcoholic fatty liver disease (NAFLD), resulting in cancer progression. Benzo(a)pyrene (B[a]P) is a common environmental foodborne pollutant found smoke fire-grilled foods, can have an adverse effect on human health. Hepatocellular carcinoma (HCC) fifth leading cause second cancer-related deaths worldwide. The epidemiological studies suggest that both risk...
Deep learning methods have demonstrated strong performance in objection tasks; however, their ability to learn domain-specific applications with limited training data remains a significant challenge. Transfer techniques address this issue by leveraging knowledge from pre-training on related datasets, enabling faster and more efficient for new tasks. Finding the right dataset can play critical role determining success of transfer overall model performance. In paper, we investigate impact...
<title>Abstract</title> Background The quality of clinical PET/CT images is critical for both accurate diagnosis and image-based research. However, current image assessment (IQA) methods predominantly rely on handcrafted features region-specific analyses, thereby limiting automation in whole-body multi-center evaluations. This study aims to develop an expert-perceptive deep learning-based IQA system [18F]FDG tackle the lack automated, interpretable assessments quality. Methods retrospective...
Esophageal cancer is one of the most common malignant tumors, with China accounting for 50% world's total incidence. Concurrent chemoradiotherapy (cCRT) platin-based dual-drug regimen standard treatment inoperable, locally advanced esophageal in patients a good performance status. However, certain possess risk factors that heighten toxicity and reduce their tolerance to cCRT, thereby challenging feasibility treatment. This study evaluates an alternative therapeutic approach combining...
The quality of clinical PET/CT images is critical for both accurate diagnosis and image-based research. However, current image assessment (IQA) methods predominantly rely on handcrafted features region-specific analyses, thereby limiting automation in whole-body multicenter evaluations. This study aims to develop an expert-perceptive deep learning-based IQA system [18F]FDG tackle the lack automated, interpretable assessments quality. retrospective included scans from 718 patients. Automated...
Abstract Introduction: Liquid biopsy NGS assays allow for detection of genes clinically relevant to oncology including structural variants such as amplifications and translocations. Due their low concentration in plasma, can be difficult detect with liquid biopsy. Translocations particular present challenges due prevalence ctDNA opposed RNA. PGDx elio™ plasma focus Dx is an IVD tumor profiling assay which reports 33 high sensitivity, specificity, accuracy, reproducibility. Here, the...
Background: This propensity score matching (PSM) analysis assessed the influence of examined lymph nodes (ELNs) count on stage migration and survival in node-negative (pN0) gastric cancer (GC) patients. Methods: We performed a retrospective 7,620 GC patients who underwent curative resection three Chinese medical centers. PSM was used to reduce confounding effects between pN0 with ELNs <16 or ≥16. Survival differences among various subgroups were analyzed assess impact accordance overall (OS)...
With the rapid progress of sensor technology, underwater monitoring wireless network (UMWSN) equipped with water resource capabilities have surfaced. UMWSN is currently emerging as a popular research and application area, wide range applications in various fields, including but not limited to disaster warning, pollutant hydrological data monitoring. However, due size computing power sensors, are exceedingly susceptible security attacks by contaminating entities. In order tackle problems...