A5044155079- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Colorectal Cancer Treatments and Studies
- Circular RNAs in diseases
- Genetics, Aging, and Longevity in Model Organisms
- Cancer Research and Treatments
- Cancer therapeutics and mechanisms
- Energy and Environment Impacts
- Intensive Care Unit Cognitive Disorders
- Toxic Organic Pollutants Impact
- Cancer-related molecular mechanisms research
- Pneumonia and Respiratory Infections
- Streptococcal Infections and Treatments
- Bacterial Infections and Vaccines
- Cancer-related Molecular Pathways
- Sepsis Diagnosis and Treatment
- Extracellular vesicles in disease
- Cancer Genomics and Diagnostics
- Nosocomial Infections in ICU
- Birth, Development, and Health
- Ubiquitin and proteasome pathways
- MicroRNA in disease regulation
Shanghai Jiao Tong University
2024-2025
Xcovery (United States)
2019-2021
Xuzhou Medical College
2021
Weatherford College
2021
The First People’s Hospital of Lianyungang
2021
Henan University of Science and Technology
2016
Hubei University of Technology
2015
Abstract Background Benzo[a]pyrene (B[a]P), a carcinogen pollutant produced by combustion processes, is present in the western diet with grilled meats. Chronic exposure of B[a]P hepatocellular carcinoma (HCC) cells promotes metastasis rather than primary proliferation, implying an unknown mechanism B[a]P‐induced malignancy. Given that exosomes carry bioactive molecules to distant sites, we investigated whether and how mediate cancer‐stroma communications for toxicologically associated...
Benzo[a]pyrene (B[a]P) is a widespread and persistent organic pollutant that poses serious threats to human health. Although its carcinogenic properties have been extensively studied, developmental toxicity underlying mechanisms remain poorly understood. In this study, we employed Caenorhabditis elegans (C. elegans) as model organism investigate the effects of B[a]P exposure during early stages. To comprehensively assess B[a]P-induced toxicity, high-throughput sequencing along with...
Abstract Mycoplasma pneumoniae infection may induce a systemic hypercoagulable abnormality, like organ embolism and infarction. Indexes of blood coagulation C-reactive protein (CRP) have been reported different between healthy people mycoplasma pneumonia (MPP) patients, but this difference in MPP patients with chest imaging findings has rarely reported. We performed retrospective study 101 children 119 controls, combined radiological examination tests, to compare the CRP level among...
BACKGROUND MicroRNA-125a (miR-125a) has been involved with many diseases, such as hepatocellular carcinoma and inflammation. In this study, we aimed to investigate the molecular mechanism, including potential regulator signaling pathways, of vascular endothelial growth factor (VEGF). MATERIAL AND METHODS We divided participants into 3 groups by rs12976445 genotype performed chi-square tests evaluate differences between CC CT+TT for sex, age, grading, pT category, metastases, fludeoxyglucose...
The N-terminal domains of MdmX or Mdm2 are highly homologous and have similar conformation (Figure 1a & b). There three binding pockets for a p53 peptide (p53p), defined as F19, W23 L26 on their surfaces. Current inhibitors including nutlin-3a exhibit weak affinity to MdmX. Nutlin-3a 1c) mimics p53p with high (Kd ~ 20 nM) but very 29 M). pocket significantly differentiates the affinities between MdmX, detailed mechanism remains unclear.
Abstract Background: Sepsis is still a global public health priority. We aimed to investigate the features of sepsis with worse outcomes in single ICU China.. Methods: enrolled patients acute critically ill from China (Jan 1, 2018 Nov 30, 2019). All underwent quick diagnostic tests before and after on admission. collected data cases hospital medical records follow-up information. Outcomes were compared between who survivors those not. Results: Of 520 admissions, 214 (41.2%) adults analyzed....